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    Method of inhibiting stenosis and restenosis
    1.
    发明申请
    Method of inhibiting stenosis and restenosis 审中-公开
    抑制狭窄和再狭窄的方法

    公开(公告)号：US20050214299A1

    公开(公告)日：2005-09-29

    申请号：US10662061

    申请日：2003-09-12

    申请人： Christopher Horvath ,  Patricia Rao

    发明人： Christopher Horvath ,  Patricia Rao

    IPC分类号： A61K45/06 ,  A61K39/395 ,  A61M29/02 ,  A61M31/00 ,  A61P9/10 ,  A61P9/14 ,  C07K16/28 ,  C07K16/36

    CPC分类号： C07K16/2866 ,  A61K2039/505 ,  A61M25/104 ,  C07K16/2845 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2319/00

    摘要： The invention relates to a method of inhibiting stenosis or restenosis in a subject. In one embodiment, an agent which inhibits recruitment and/or adhesion of neutrophils and mononuclear cells to a site of vascular injury is administered to a subject in need thereof. In another embodiment, a first agent which inhibits recruitment and/or adhesion of neutrophils to a site of vascular injury, and a second agent which inhibits recruitment and/or adhesion of mononuclear cells to a site of vascular injury are administered to a subject in need thereof. In particular embodiments, the agents are antibodies or antigen-binding fragments thereof which bind to CD18 or CCR2.

    摘要翻译： 本发明涉及一种抑制受试者狭窄或再狭窄的方法。 在一个实施方案中，向有需要的受试者施用抑制嗜中性粒细胞和单核细胞向血管损伤部位的募集和/或粘附的药剂。 在另一个实施方案中，将抑制嗜中性粒细胞募集和/或粘附到血管损伤部位的第一药剂和抑制单核细胞募集和/或粘附到血管损伤部位的第二药剂施用于需要的受试者 其中。 在具体实施方案中，所述试剂是结合CD18或CCR2的抗体或其抗原结合片段。

    LASER SYSTEM FOR EYE SURGERY
    2.
    发明申请
    LASER SYSTEM FOR EYE SURGERY 审中-公开
    眼科手术激光系统

    公开(公告)号：US20160089269A1

    公开(公告)日：2016-03-31

    申请号：US14842747

    申请日：2015-09-01

    申请人： Christopher Horvath ,  Vanessa I. Vera

    发明人： Christopher Horvath ,  Vanessa I. Vera

    IPC分类号： A61F9/007 ,  A61F9/008

    摘要： The here described invention generally relates to systems for laser eye surgery. It certain embodiments it discloses systems to perform femtosecond eye surgery without docking between the laser delivery system and the patient's eye as well as certain laser delivery system configurations that allow integration of laser delivery systems into a surgical microscope in specific ways, as well as integration into a slit lamp system.

    摘要翻译： 这里描述的发明一般涉及用于激光眼睛手术的系统。 在某些实施例中，它公开了在不进行激光输送系统和患者眼睛之间的对接的情况下执行飞秒眼科手术的系统以及允许以特定方式将激光输送系统整合到手术显微镜中的某些激光输送系统配置， 裂隙灯系统。

    Devices for deploying intraocular shunts
    5.
    发明授权
    Devices for deploying intraocular shunts 有权
    用于部署眼内分流装置

    公开(公告)号：US09095411B2

    公开(公告)日：2015-08-04

    申请号：US12946251

    申请日：2010-11-15

    申请人： Christopher Horvath ,  Laszlo O. Romoda ,  Guenther Grabner ,  Herbert A. Reitsamer

    发明人： Christopher Horvath ,  Laszlo O. Romoda ,  Guenther Grabner ,  Herbert A. Reitsamer

    IPC分类号： A61F9/007

    CPC分类号： A61F9/00781

    摘要： The present invention generally relates to devices for deploying intraocular shunts without the use of an optical apparatus that contacts an eye, such as a goniolens. In certain embodiments, devices of the invention include a housing including a proximal portion and a distal portion, in which the distal portion is movable within the proximal portion, a deployment mechanism at least partially disposed within the housing, and a hollow shaft coupled to the deployment mechanism, in which the shaft is configured to hold an intraocular shunt.

    摘要翻译： 本发明总体上涉及用于部署眼内分流而不使用与眼睛接触的光学装置（例如巨像）的装置。 在某些实施例中，本发明的装置包括壳体，其包括近端部分和远端部分，远端部分可在近侧部分内移动，至少部分地设置在壳体内的展开机构，以及联接到 展开机构，其中轴被构造成保持眼内分流。

    White coherent laser light launched into nano fibers for surgical illumination
    6.
    发明授权
    White coherent laser light launched into nano fibers for surgical illumination 有权
    白色相干激光发射到纳米纤维用于手术照明

    公开(公告)号：US09055885B2

    公开(公告)日：2015-06-16

    申请号：US14076215

    申请日：2013-11-10

    申请人： Christopher Horvath ,  Michael J. Papac ,  Laszlo Romoda ,  Ronald T. Smith ,  Michael J. Yadlowsky

    发明人： Christopher Horvath ,  Michael J. Papac ,  Laszlo Romoda ,  Ronald T. Smith ,  Michael J. Yadlowsky

    IPC分类号： A61B1/07 ,  A61B19/00 ,  A61F9/008

    CPC分类号： A61B1/07 ,  A61B3/0008 ,  A61B90/30 ,  A61B2090/306 ,  A61F9/008

    摘要： Disclosed is an exemplary surgical illumination system that includes a first laser configured to emit a first light beam having a first spectral range, and an illumination probe optically connectable to the first laser. The first laser may be configured as a supercontinuum laser. The surgical illumination system may include a second laser configured to emit a second light beam having a second spectral range, and a beam combiner for combing the first and second laser beams to form a third laser beam having a spectral range of the first and second lasers. The illumination probe includes a fiber optic cable for delivering at least a portion of the first light beam to a surgical site. The fiber optic cable includes a fiber optic core having a diameter of 100 microns or less.

    摘要翻译： 公开了一种示例性外科照明系统，其包括被配置为发射具有第一光谱范围的第一光束的第一激光器和可光学地连接到第一激光器的照明探针。 第一激光器可以被配置为超连续谱激光器。 外科照明系统可以包括配置成发射具有第二光谱范围的第二光束的第二激光器和用于梳理第一和第二激光束以形成具有第一和第二激光器的光谱范围的第三激光束的光束组合器 。 照明探针包括用于将至少一部分第一光束输送到手术部位的光纤电缆。 光纤电缆包括直径为100微米或更小的光纤芯。

    Devices and methods for implanting a shunt in the suprachoroidal space
    7.
    发明授权
    Devices and methods for implanting a shunt in the suprachoroidal space 有权
    用于在脉络膜上空间植入分流的装置和方法

    公开(公告)号：US08758290B2

    公开(公告)日：2014-06-24

    申请号：US13336803

    申请日：2011-12-23

    申请人： Christopher Horvath ,  Ronald D. Bache ,  Laszlo O. Romoda ,  Guenther Grabner ,  Herbert A. Reitsamer ,  John R. Samples

    发明人： Christopher Horvath ,  Ronald D. Bache ,  Laszlo O. Romoda ,  Guenther Grabner ,  Herbert A. Reitsamer ,  John R. Samples

    IPC分类号： A61M5/00 ,  A61F11/00

    CPC分类号： A61F9/00781

    摘要： The invention generally relates to devices and methods for implanting a shunt in the suprachoroidal space of an eye. In certain aspects, devices of the invention include a housing, a deployment mechanism at least partially disposed within the housing, and a flexible hollow shaft coupled to the deployment mechanism, in which the shaft holds an intraocular shunt, and is configured to self-guide the shunt along a scleral spur of an eye as the shunt is deployed from the shaft. Such a device may be inserted into an eye and used to deploy a shunt within the eye such that a proximal portion of the shunt receives fluid from an anterior chamber of an eye and a distal portion of the shunt directs the fluid to the suprachoroidal space.

    摘要翻译： 本发明一般涉及用于将分流器植入眼睛的脉络膜上空间的装置和方法。 在某些方面，本发明的装置包括壳体，至少部分地设置在壳体内的展开机构，以及联接到展开机构的柔性中空轴，其中轴保持眼内分流，并且构造成自导向 因为分流器从轴部署而沿着巩膜上的分支。 这种装置可被插入到眼睛中并且用于在眼睛内展开分路，使得分流器的近端部分接收来自眼睛的前房的流体并且分流器的远端部分将流体引导到脉管外空间。

    Intraocular shunt deployment devices
    8.
    发明授权
    Intraocular shunt deployment devices 有权
    眼内分流装置

    公开(公告)号：US08721702B2

    公开(公告)日：2014-05-13

    申请号：US12946645

    申请日：2010-11-15

    申请人： Laszlo O. Romoda ,  Christopher Horvath

    发明人： Laszlo O. Romoda ,  Christopher Horvath

    IPC分类号： A61F2/06

    CPC分类号： A61F9/00781 ,  A61F9/0008

    摘要： The invention generally relates to devices for deploying an intraocular shunt within an eye. In certain embodiments, devices of the invention include a housing, a deployment mechanism at least partially disposed within the housing, and a hollow shaft coupled to the deployment mechanism, in which the shaft is configured to hold an intraocular shunt, and in which rotation of the deployment mechanism results in deployment of the shunt.

    摘要翻译： 本发明一般涉及用于在眼睛内部署眼内分流装置。 在某些实施例中，本发明的装置包括壳体，至少部分地设置在壳体内的展开机构，以及联接到展开机构的中空轴，其中轴构造成保持眼内分流，并且其中旋转 部署机制导致了分流器的部署。

    White coherent laser light launched into nano fibers for surgical illumination
    10.
    发明申请
    White coherent laser light launched into nano fibers for surgical illumination 审中-公开
    白色相干激光发射到纳米纤维用于手术照明

    公开(公告)号：US20120203075A1

    公开(公告)日：2012-08-09

    申请号：US13313105

    申请日：2011-12-07

    申请人： Christopher Horvath ,  Michael J. Papac ,  Laszlo Romoda ,  Ronald T. Smith ,  Michael J. Yadlowsky

    发明人： Christopher Horvath ,  Michael J. Papac ,  Laszlo Romoda ,  Ronald T. Smith ,  Michael J. Yadlowsky

    IPC分类号： A61B1/07

    CPC分类号： A61B1/07 ,  A61B3/0008 ,  A61B90/30 ,  A61B2090/306 ,  A61F9/008

    摘要： Disclosed is an exemplary surgical illumination system that includes a first laser configured to emit a first light beam having a first spectral range, and an illumination probe optically connectable to the first laser. The first laser may be configured as a supercontinuum laser. The surgical illumination system may include a second laser configured to emit a second light beam having a second spectral range, and a beam combiner for combing the first and second laser beams to form a third laser beam having a spectral range of the first and second lasers. The illumination probe includes a fiber optic cable for delivering at least a portion of the first light beam to a surgical site. The fiber optic cable includes a fiber optic core having a diameter of 100 microns or less.

    摘要翻译： 公开了一种示例性外科照明系统，其包括被配置为发射具有第一光谱范围的第一光束的第一激光器和可光学地连接到第一激光器的照明探针。 第一激光器可以被配置为超连续谱激光器。 外科照明系统可以包括配置成发射具有第二光谱范围的第二光束的第二激光器和用于梳理第一和第二激光束以形成具有第一和第二激光器的光谱范围的第三激光束的光束组合器 。 照明探针包括用于将至少一部分第一光束输送到手术部位的光纤电缆。 光纤电缆包括直径为100微米或更小的光纤芯。