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公开(公告)号:US20170197940A1
公开(公告)日:2017-07-13
申请号:US15320810
申请日:2015-07-02
申请人: Christopher M. ADAMS , Doug BEVAN , Michael Paul CAPPARELLI , Takeru EHARA , Luciana FERRARA , Nan JI , Mitsunori KATO , Nello MAINOLFI , Erik MEREDITH , Muneto MOGI , James J. POWERS , Ganesh PRASANNA
发明人: Christopher M. ADAMS , Doug BEVAN , Michael Paul CAPPARELLI , Takeru EHARA , Luciana FERRARA , Nan JI , Mitsunori KATO , Nello MAINOLFI , Erik MEREDITH , Muneto MOGI , James J. POWERS , Ganesh PRASANNA
IPC分类号: C07D401/14 , C07D401/12 , A61K31/454 , C07D413/14 , A61K31/4725 , A61K31/4439 , C07D405/14 , A61K9/00 , A61K31/4545
CPC分类号: C07D401/14 , A61K9/0048 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , C07D401/10 , C07D401/12 , C07D405/14 , C07D413/14
摘要: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号:US20170197941A1
公开(公告)日:2017-07-13
申请号:US15320815
申请日:2015-07-02
申请人: Christopher M. ADAMS , David B. BELANGER , Doug BEVAN , Philippe BOLDUC , Takeru EHARA , Luciana FERRARA , Nan JI , Mitsunori KATO , Erik MEREDITH , Muneto MOGI , James J. POWERS , Ganesh PRASANNA
发明人: Christopher M. ADAMS , David B. BELANGER , Doug BEVAN , Philippe BOLDUC , Takeru EHARA , Luciana FERRARA , Nan JI , Mitsunori KATO , Erik MEREDITH , Muneto MOGI , James J. POWERS , Ganesh PRASANNA
IPC分类号: C07D401/14 , C07D401/04
CPC分类号: C07D401/14 , A61K31/4545 , A61K31/4985 , A61K31/519 , A61K31/53 , A61K45/06 , C07D401/04 , C07D401/12 , A61K2300/00
摘要: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号:US20170197950A1
公开(公告)日:2017-07-13
申请号:US15320813
申请日:2015-07-02
申请人: Christopher M. ADAMS , David B. BELANGER , Doug BEVAN , Takeru EHARA , Luciana FERRARA , Nan JI , Donglei LIU , Erik MEREDITH , Muneto MOGI , James POWERS , Ganesh PRASANNA , Mitsunori KATO
发明人: Christopher M. ADAMS , David B. BELANGER , Doug BEVAN , Takeru EHARA , Luciana FERRARA , Nan JI , Donglei LIU , Erik MEREDITH , Muneto MOGI , James POWERS , Ganesh PRASANNA , Mitsunori KATO
IPC分类号: C07D409/14 , A61K31/4439 , A61K31/4725 , A61K9/00 , A61K31/4545
CPC分类号: C07D409/14 , A61K9/0048 , A61K31/4439 , A61K31/4545 , A61K31/4725
摘要: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号:US20160243132A1
公开(公告)日:2016-08-25
申请号:US15051246
申请日:2016-02-23
IPC分类号: A61K31/58 , A61K31/353 , C12Q1/68 , A61K31/473 , A61K31/407 , G01N33/50 , A61K31/56 , A61K31/4166
CPC分类号: A61K31/58 , A61K31/215 , A61K31/352 , A61K31/353 , A61K31/36 , A61K31/382 , A61K31/404 , A61K31/407 , A61K31/4164 , A61K31/4166 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/4706 , A61K31/473 , A61K31/56 , A61K31/565 , C12Q1/6809 , C12Q2600/136 , G01N33/5023 , G01N2800/10 , G01N2800/52 , A61K2300/00
摘要: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译: 一方面,本发明涉及通过向有需要的动物提供有效量的化合物来治疗肌肉萎缩的方法。 该化合物可以调节肌肉萎缩特征的多个mRNA的表达水平。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具,而不意在限制本发明。
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