公开(公告)号：US20170197950A1

公开(公告)日：2017-07-13

申请号：US15320813

申请日：2015-07-02

申请人： Christopher M. ADAMS ,  David B. BELANGER ,  Doug BEVAN ,  Takeru EHARA ,  Luciana FERRARA ,  Nan JI ,  Donglei LIU ,  Erik MEREDITH ,  Muneto MOGI ,  James POWERS ,  Ganesh PRASANNA ,  Mitsunori KATO

发明人： Christopher M. ADAMS ,  David B. BELANGER ,  Doug BEVAN ,  Takeru EHARA ,  Luciana FERRARA ,  Nan JI ,  Donglei LIU ,  Erik MEREDITH ,  Muneto MOGI ,  James POWERS ,  Ganesh PRASANNA ,  Mitsunori KATO

IPC分类号： C07D409/14 ,  A61K31/4439 ,  A61K31/4725 ,  A61K9/00 ,  A61K31/4545

CPC分类号： C07D409/14 ,  A61K9/0048 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4725

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20170197941A1

公开(公告)日：2017-07-13

申请号：US15320815

申请日：2015-07-02

申请人： Christopher M. ADAMS ,  David B. BELANGER ,  Doug BEVAN ,  Philippe BOLDUC ,  Takeru EHARA ,  Luciana FERRARA ,  Nan JI ,  Mitsunori KATO ,  Erik MEREDITH ,  Muneto MOGI ,  James J. POWERS ,  Ganesh PRASANNA

发明人： Christopher M. ADAMS ,  David B. BELANGER ,  Doug BEVAN ,  Philippe BOLDUC ,  Takeru EHARA ,  Luciana FERRARA ,  Nan JI ,  Mitsunori KATO ,  Erik MEREDITH ,  Muneto MOGI ,  James J. POWERS ,  Ganesh PRASANNA

IPC分类号： C07D401/14 ,  C07D401/04

CPC分类号： C07D401/14 ,  A61K31/4545 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/53 ,  A61K45/06 ,  C07D401/04 ,  C07D401/12 ,  A61K2300/00

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20170197940A1

公开(公告)日：2017-07-13

申请号：US15320810

申请日：2015-07-02

申请人： Christopher M. ADAMS ,  Doug BEVAN ,  Michael Paul CAPPARELLI ,  Takeru EHARA ,  Luciana FERRARA ,  Nan JI ,  Mitsunori KATO ,  Nello MAINOLFI ,  Erik MEREDITH ,  Muneto MOGI ,  James J. POWERS ,  Ganesh PRASANNA

发明人： Christopher M. ADAMS ,  Doug BEVAN ,  Michael Paul CAPPARELLI ,  Takeru EHARA ,  Luciana FERRARA ,  Nan JI ,  Mitsunori KATO ,  Nello MAINOLFI ,  Erik MEREDITH ,  Muneto MOGI ,  James J. POWERS ,  Ganesh PRASANNA

IPC分类号： C07D401/14 ,  C07D401/12 ,  A61K31/454 ,  C07D413/14 ,  A61K31/4725 ,  A61K31/4439 ,  C07D405/14 ,  A61K9/00 ,  A61K31/4545

CPC分类号： C07D401/14 ,  A61K9/0048 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4725 ,  C07D401/10 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20160311779A1

公开(公告)日：2016-10-27

申请号：US15032872

申请日：2014-10-29

申请人： Christopher ADAMS ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Toshio KAWANAMI ,  Nello MAINOLFI ,  James J. POWERS ,  Michael SERRANO-WU ,  Chun ZHANG ,  Rajeshri Ganesh KARKI

发明人： Christopher ADAMS ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Nello MAINOLFI ,  James POWERS ,  Michael Serrano-WU ,  Chun ZHANG

IPC分类号： C07D235/12 ,  C07D235/14

CPC分类号： C07D235/12 ,  A61K31/4184 ,  A61K45/06 ,  C07D235/14 ,  A61K2300/00

摘要： The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

摘要翻译： 本发明提供式（I）化合物，其用于制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。

公开(公告)号：US20150250767A1

公开(公告)日：2015-09-10

申请号：US14715594

申请日：2015-05-19

申请人： Christopher Michael ADAMS ,  Charles BABU ,  Michael Paul CAPPARELLI ,  Jian DING ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Liang XUE ,  Nello MAINOLFI ,  James J. POWERS ,  Michael H. SERRANO-WU ,  Chun ZHANG

发明人： Christopher Michael ADAMS ,  Charles BABU ,  Michael Paul CAPPARELLI ,  Jian DING ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Liang XUE ,  Nello MAINOLFI ,  James J. POWERS ,  Michael H. SERRANO-WU ,  Chun ZHANG

IPC分类号： A61K31/4184 ,  A61K31/4439 ,  A61K31/4245

CPC分类号： A61K31/4184 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/08 ,  C07D403/14 ,  C07D413/06 ,  C07D413/14 ,  C07D487/04 ,  C07D491/048

摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20130296377A1

公开(公告)日：2013-11-07

申请号：US13826725

申请日：2013-03-14

申请人： Christopher Michael ADAMS ,  Charles BABU ,  Michael Paul CAPPARELLI ,  Jian DING ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Xue LIANG ,  Nello MAINOLFI ,  James J. POWERS ,  Michael H. SERRANO-WU ,  Chun ZHANG

发明人： Christopher Michael ADAMS ,  Charles BABU ,  Michael Paul CAPPARELLI ,  Jian DING ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Xue LIANG ,  Nello MAINOLFI ,  James J. POWERS ,  Michael H. SERRANO-WU ,  Chun ZHANG

IPC分类号： C07D491/048 ,  A61K31/4184 ,  C07D413/06 ,  A61K45/06 ,  C07D403/14 ,  C07D401/14 ,  A61K31/4439 ,  C07D403/06 ,  A61K31/423

CPC分类号： A61K31/4184 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/08 ,  C07D403/14 ,  C07D413/06 ,  C07D413/14 ,  C07D487/04 ,  C07D491/048

摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20160024079A1

公开(公告)日：2016-01-28

申请号：US14774430

申请日：2014-03-13

申请人： Christopher Michael ADAMS ,  Charles BABU ,  Michael Paul CAPPARELLI ,  Jian DING ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Liang XUE ,  Nello MAINOLFI ,  James J. POWERS ,  Michael H. SERRANO-WU ,  Chun ZHANG

发明人： Christopher Michael ADAMS ,  Charles BABU ,  Michael Paul CAPPARELLI ,  Jian DING ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Liang XUE ,  Nello MAINOLFI ,  James J. POWERS ,  Michael H. SERRANO-WU ,  Chun ZHANG

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.

摘要翻译： 本发明提供了式（I）化合物：其中X为N或CH，Y为NH，O或S，制备这些化合物的方法及其作为因子B抑制剂用于治疗与补体相关的病症和疾病的用途 替代途径激活如年龄相关性黄斑变性，糖尿病性视网膜病变和相关眼科疾病。 本发明还提供药物组合物和药理活性剂的组合。

公开(公告)号：US20110263560A1

公开(公告)日：2011-10-27

申请号：US13176930

申请日：2011-07-06

申请人： Werner BREITENSTEIN ,  Takeru EHARA ,  Claus EHRHARDT ,  Philipp GROSCHE ,  Yuko HITOMI ,  Yuki IWAKI ,  Takanori KANAZAWA ,  Kazuhide KONISHI ,  Juergen Klaus MAIBAUM ,  Keiichi MASUYA ,  Atsuko Nihonyanagi ,  Nils OSTERMANN ,  Masaki SUZUKI ,  Atsushi TOYAO ,  Fumiaki YOKOKAWA

发明人： Werner BREITENSTEIN ,  Takeru EHARA ,  Claus EHRHARDT ,  Philipp GROSCHE ,  Yuko HITOMI ,  Yuki IWAKI ,  Takanori KANAZAWA ,  Kazuhide KONISHI ,  Juergen Klaus MAIBAUM ,  Keiichi MASUYA ,  Atsuko Nihonyanagi ,  Nils OSTERMANN ,  Masaki SUZUKI ,  Atsushi TOYAO ,  Fumiaki YOKOKAWA

IPC分类号： A61K31/4523 ,  C07D401/10 ,  C07D401/12 ,  C07D413/12 ,  C07D413/04 ,  A61P9/12 ,  C07D417/12 ,  A61K31/451 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/538 ,  A61K31/5415 ,  C07D211/60 ,  C07D405/12

CPC分类号： C07D471/04 ,  C07D211/60 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/10 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： 3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.

摘要翻译： 3,4-取代的哌啶化合物，这些化合物用于诊断和治疗温血动物，特别是用于治疗依赖于肾素活性的疾病（=病症）; 使用该类化合物制备用于治疗依赖于肾素活性的疾病的药物制剂; 使用该类化合物治疗依赖于肾素活性的疾病; 包含3,4-取代的哌啶化合物的药物制剂和/或包括给药3,4代哌啶化合物的方法，制备3,4-取代的哌啶化合物的方法和新的中间体和部分步骤 他们的合成被公开。 3,4-二取代的哌啶化合物具有式（I），其中符号具有说明书中定义的含义。