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公开(公告)号：US10220124B2
公开(公告)日：2019-03-05
申请号：US14002058
申请日：2012-02-28
申请人： Christopher Rylander , Mehmet A. Kosoglu , Robert L. Hood , John L. Robertson , John H. Rossmeisl , David C. Grant , Marissa N. Rylander
发明人： Christopher Rylander , Mehmet A. Kosoglu , Robert L. Hood , John L. Robertson , John H. Rossmeisl , David C. Grant , Marissa N. Rylander
摘要： The present invention relates to the field of optical imaging and therapeutics. More particularly, embodiments of the present invention provide minimally-invasive Fiberoptic Microneedle Devices (FMDs) for light-based therapeutics, which physically penetrate tissue and deliver light directly into the target area below the skin surface. Embodiments of the invention enable depth-selective and deep photothermal therapeutics and include methods of treating cancer, methods of re-shaping or removing adipose tissue, and methods of delivering drugs or co-delivering drugs and energy to selected tissue.
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公开(公告)号：US20130338627A1
公开(公告)日：2013-12-19
申请号：US14002058
申请日：2012-02-28
申请人： Christopher Rylander , Mehmet A. Kosoglu , Robert L. Hood , John L Robertson , John H. Rossmeisl , David C. Grant , Marissa N. Rylander
发明人： Christopher Rylander , Mehmet A. Kosoglu , Robert L. Hood , John L Robertson , John H. Rossmeisl , David C. Grant , Marissa N. Rylander
CPC分类号： A61M1/008 , A61B18/20 , A61B18/22 , A61B2018/00452 , A61B2018/00464 , A61B2018/00476 , A61B2018/2005 , A61B2018/208 , A61M5/158 , A61M2202/08 , A61N5/062 , A61N2005/0612 , A61N2005/063 , F04C2270/0421
摘要： The present invention relates to the field of optical imaging and therapeutics. More particularly, embodiments of the present invention provide minimally-invasive Fiberoptic Microneedle Devices (FMDs) for light-based therapeutics, which physically penetrate tissue and deliver light directly into the target area below the skin surface. Embodiments of the invention enable depth-selective and deep photothermal therapeutics and include methods of treating cancer, methods of re-shaping or removing adipose tissue, and methods of delivering drugs or co-delivering drugs and energy to selected tissue.
摘要翻译： 本发明涉及光学成像和治疗领域。 更具体地，本发明的实施例提供了用于基于光的治疗剂的微创光纤微针装置（FMD），其物理地穿透组织并将光直接传递到皮肤表面下方的目标区域。 本发明的实施方案能够实现深度选择性和深度光热治疗，并且包括治疗癌症的方法，重塑或去除脂肪组织的方法，以及递送药物或将药物和能量共同递送到所选择的组织的方法。
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公开(公告)号：US20100030211A1
公开(公告)日：2010-02-04
申请号：US12491151
申请日：2009-06-24
CPC分类号： A61B18/1477 , A61B18/1206 , A61B2018/00446 , A61B2018/00613 , A61N1/05 , A61N1/327 , C12N13/00
摘要： The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
摘要翻译： 本发明提供用于体内治疗细胞增殖性疾病的方法，装置和系统。 本发明可用于治疗诸如脑肿瘤的实体瘤。 该方法依赖于非热不可逆电穿孔（IRE）在治疗的肿瘤中引起细胞死亡。
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公开(公告)号：US08992517B2
公开(公告)日：2015-03-31
申请号：US12491151
申请日：2009-06-24
CPC分类号： A61B18/1477 , A61B18/1206 , A61B2018/00446 , A61B2018/00613 , A61N1/05 , A61N1/327 , C12N13/00
摘要： The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
摘要翻译： 本发明提供用于体内治疗细胞增殖性疾病的方法，装置和系统。 本发明可用于治疗诸如脑肿瘤的实体瘤。 该方法依赖于非热不可逆电穿孔（IRE）在治疗的肿瘤中引起细胞死亡。
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公开(公告)号：US20110106221A1
公开(公告)日：2011-05-05
申请号：US12906923
申请日：2010-10-18
申请人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
发明人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
CPC分类号： C12N13/00 , A61B34/10 , A61B2018/00613 , A61B2034/104 , A61B2034/105 , A61N1/0412 , G16H50/50
摘要： The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
摘要翻译： 本发明提供了用于基于电穿孔的疗法（EBT）的系统，方法和装置。 实施例提供了通过从组织拍摄的图像对目标组织进行3D重建的数值模拟得出的患者特异性治疗方案，并且可选地考虑物理约束或动态组织属性中的一种或多种。 本发明还涉及用于递送用于不可逆电穿孔的双极电脉冲的系统，方法和装置，其显示对EBT诱导的递送至组织的过量电荷通常相关的组织的减少或不损伤。
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公开(公告)号：US09198733B2
公开(公告)日：2015-12-01
申请号：US12906923
申请日：2010-10-18
申请人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
发明人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
CPC分类号： C12N13/00 , A61B34/10 , A61B2018/00613 , A61B2034/104 , A61B2034/105 , A61N1/0412 , G16H50/50
摘要： The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
摘要翻译： 本发明提供了用于基于电穿孔的疗法（EBT）的系统，方法和装置。 实施例提供了通过从组织拍摄的图像对目标组织进行3D重建的数值模拟得出的患者特异性治疗方案，并且可选地考虑物理约束或动态组织属性中的一种或多种。 本发明还涉及用于递送用于不可逆电穿孔的双极电脉冲的系统，方法和装置，其显示对EBT诱导的递送至组织的过量电荷通常相关的组织的减少或不损伤。
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