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    Bifunctional Predictors of Cancer Treatment Sensitivity and Resistance
    1.
    发明申请
    Bifunctional Predictors of Cancer Treatment Sensitivity and Resistance 审中-公开
    癌症治疗敏感性和抗性的双功能预测因子

    公开(公告)号：US20100178651A1

    公开(公告)日：2010-07-15

    申请号：US12513338

    申请日：2007-11-05

    申请人： Christos Hatzis ,  Fraser W Symmans ,  Lajos Pusztai

    发明人： Christos Hatzis ,  Fraser W Symmans ,  Lajos Pusztai

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136

    摘要： The present invention provides the identification of genes that are expressed in tumors to indicate responsiveness or resistance to an agent or class of agents. More particularly, these genes show expression associated with responsiveness to one agent or class of agents is inversely related to expression in association with another class of agents. One or more of theses genes of the present invention can be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by the responsive agent as well as to identify tumors that should avoid treatment by the resistant agent.

    摘要翻译： 本发明提供了在肿瘤中表达的基因的鉴定，以指示对试剂或试剂类的反应性或抗性。 更具体地说，这些基因表现出与一种药剂的反应性相关的表达或与另一类药剂相关的表达是负相关的。 本发明的一个或多个这些基因可以用作标记物（或替代标记物）来鉴定可能被响应剂成功治疗的肿瘤以及鉴定应该避免被抗药剂治疗的肿瘤。

    INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED GENES
    3.
    发明申请
    INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED GENES 审中-公开
    雌激素受体（ER）和ER相关基因的基因表达指数

    公开(公告)号：US20100311601A1

    公开(公告)日：2010-12-09

    申请号：US12772816

    申请日：2010-05-03

    申请人： W. Fraser Symmans ,  Christos Hatzis ,  Lajos Pusztai

    发明人： W. Fraser Symmans ,  Christos Hatzis ,  Lajos Pusztai

    IPC分类号： C12Q1/68 ,  C40B30/02

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G16B25/00

    摘要： The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine therapy or chemotherapy.

    摘要翻译： 本发明提供了在对给定治疗剂有反应的肿瘤中表达的基因的鉴定和组合，并且其组合表达可用作与对该治疗剂的反应性相关的指标。 本发明的一个或多个基因可用作标志物（或替代标记物），以鉴定可能由该试剂或类别的试剂例如激素或内分泌治疗或化学疗法成功治疗的肿瘤。

    Method of measuring residual cancer and predicting patient survival
    4.
    发明申请
    Method of measuring residual cancer and predicting patient survival 有权
    测量残留癌症并预测患者生存的方法

    公开(公告)号：US20070248948A1

    公开(公告)日：2007-10-25

    申请号：US11786980

    申请日：2007-04-13

    申请人： Christos Hatzis ,  W. Symmans ,  Lajos Pusztai

    发明人： Christos Hatzis ,  W. Symmans ,  Lajos Pusztai

    IPC分类号： C12Q1/00 ,  G06F19/00

    CPC分类号： G01N33/57484 ,  G01N33/574 ,  G01N33/57415

    摘要： Method of Measuring Residual Cancer and Predicting Patient Survival Disclosed is a method for determining survival and relapse of a patient undergoing therapy for a tumor by determining a residual cancer burden index based on the bidimensional diameters of a primary tumor bed of said tumor in a resection specimen, the proportion of the primary tumor bed area that contains invasive carcinoma, the number of regional lymph nodes containing metastatic carcinoma, the diameter of the largest metastasis in an regional lymph node; and the fractional reduction in lymph node size with each added positive lymph node.

    摘要翻译： 测量残留癌症和预测患者生存的方法公开了一种通过根据切除标本中所述肿瘤的原发肿瘤床的二维直径确定残留癌症负担指数来确定进行肿瘤治疗的患者的存活和复发的方法 ，包括侵袭性癌的原发性肿瘤床面积比例，淋巴结转移区域淋巴结数目，淋巴结转移最大的直径; 和淋巴结大小的分数减少每个添加阳性淋巴结。

    Method of measuring residual cancer and predicting patient survival
    5.
    发明授权
    Method of measuring residual cancer and predicting patient survival 有权
    测量残留癌症并预测患者生存的方法

    公开(公告)号：US07711494B2

    公开(公告)日：2010-05-04

    申请号：US11786980

    申请日：2007-04-13

    申请人： Christos Hatzis ,  W. Fraser Symmans ,  Lajos Pusztai

    发明人： Christos Hatzis ,  W. Fraser Symmans ,  Lajos Pusztai

    IPC分类号： C12Q1/00 ,  G06F19/00

    CPC分类号： G01N33/57484 ,  G01N33/574 ,  G01N33/57415

    摘要： Disclosed is a method for determining survival and relapse of a patient undergoing therapy for a tumor by determining a residual cancer burden index based on the bidimensional diameters of a primary tumor bed of said tumor in a resection specimen, the proportion of the primary tumor bed area that contains invasive carcinoma, the number of regional lymph nodes containing metastatic carcinoma, the diameter of the largest metastasis in an regional lymph node; and the fractional reduction in lymph node size with each added positive lymph node.

    摘要翻译： 公开了一种通过根据切除标本中所述肿瘤的原发肿瘤床的二维直径确定残留癌症负担指数来确定进行肿瘤治疗的患者的存活和复发的方法，原发性肿瘤床面积的比例 包括侵袭性癌，包含转移性癌的局部淋巴结数目，区域性淋巴结中最大转移的直径; 和淋巴结大小的分数减少每个添加阳性淋巴结。

    Hydrolysis and fractionation of lignocellulosic biomass
    6.
    发明授权
    Hydrolysis and fractionation of lignocellulosic biomass 失效

    公开(公告)号：US6022419A

    公开(公告)日：2000-02-08

    申请号：US723399

    申请日：1996-09-30

    申请人： Robert W. Torget ,  Nandan Padukone ,  Christos Hatzis ,  Charles E. Wyman

    发明人： Robert W. Torget ,  Nandan Padukone ,  Christos Hatzis ,  Charles E. Wyman

    IPC分类号： C07G99/00 ,  C08H8/00 ,  C13K1/02 ,  D21C3/04 ,  C07G17/00 ,  C08B5/04 ,  C12P19/02

    CPC分类号： C08H8/00 ,  C07G17/00 ,  C13K1/02 ,  D21C3/04

    摘要： A multi-function process is described for the hydrolysis and fractionation of lignocellulosic biomass to separate hemicellulosic sugars from other biomass components such as extractives and proteins; a portion of the solubilized lignin; cellulose; glucose derived from cellulose; and insoluble lignin from said biomass comprising one or more of the following: optionally, as function 1, introducing a dilute acid of pH 1.0-5.0 into a continual shrinking bed reactor containing a lignocellulosic biomass material at a temperature of about 94 to about 160.degree. C. for a period of about 10 to about 120 minutes at a volumetric flow rate of about 1 to about 5 reactor volumes to effect solubilization of extractives, lignin, and protein by keeping the solid to liquid ratio constant throughout the solubilization process; as function 2, introducing a dilute acid of pH 1.0-5.0, either as virgin acid or an acidic stream from another function, into a continual shrinking bed reactor containing either fresh biomass or the partially fractionated lignocellulosic biomass material from function 1 at a temperature of about 94-220.degree. C. for a period of about 10 to about 60 minutes at a volumetric flow rate of about 1 to about 5 reactor volumes to effect solubilization of hemicellulosic sugars, semisoluble sugars and other compounds, and amorphous glucans by keeping the solid to liquid ratio constant throughout the solubilization process; as function 3, optionally, introducing a dilute acid of pH 1.0-5.0 either as virgin acid or an acidic stream from another function, into a continual shrinking bed reactor containing the partially fractionated lignocellulosic biomass material from function 2 at a temperature of about 180-280.degree. C. for a period of about 10 to about 60 minutes at a volumetric flow rate of 1 to about 5 reactor volumes to effect solubilization of cellulosic sugars by keeping the solid to liquid ratio constant throughout the solubilization process; and as function 4, optionally, introducing a dilute acid of pH 1.0-5.0 either as virgin acid or an acidic stream from another function, into a continual shrinking bed reactor containing the partially fractionated lignocellulosic biomass material from function 3 at a temperature of about 180-280.degree. C. for a period of about 10 to about 60 minutes at a volumetric flow rate of about 1 to about 5 reactor volumes to effect solubilization of cellulosic sugars by keeping the solid to liquid ratio constant throughout the solubilization process.