公开(公告)号：US10934322B2

公开(公告)日：2021-03-02

申请号：US15977851

申请日：2018-05-11

申请人： ChromaDex Inc. ,  The Queen's University of Belfast

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Ryan Dellinger ,  Troy Rhonemus ,  Sylesh Venkataraman ,  Brian Nettles

IPC分类号： C07H19/00 ,  C07H19/048 ,  C07H1/00 ,  C07H19/04

摘要： The present disclosure provides nicotinate/nicotinamide riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, and synthetic processes for the preparation thereof.

公开(公告)号：US10689411B2

公开(公告)日：2020-06-23

申请号：US15809753

申请日：2017-11-10

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： C07H19/207 ,  C07H19/048 ,  C07D307/20 ,  C07H19/20 ,  C07H19/04

摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.

公开(公告)号：US09975915B1

公开(公告)日：2018-05-22

申请号：US15809731

申请日：2017-11-10

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： C07H19/04 ,  C07H19/048

CPC分类号： C07H19/048 ,  C07B2200/13 ,  C07D307/20 ,  C07H19/04 ,  C07H19/20

摘要： The present disclosure provides novel crystalline forms of nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, modified derivatives thereof, and phosphorylated analogs thereof, or salts, solvates, or prodrugs thereof; and methods of preparation thereof.

公开(公告)号：US20220106350A1

公开(公告)日：2022-04-07

申请号：US17551592

申请日：2021-12-15

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： C07H19/048 ,  C07D307/20 ,  C07H19/20

摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.

公开(公告)号：US10280190B2

公开(公告)日：2019-05-07

申请号：US15072121

申请日：2016-03-16

申请人： ChromaDex Inc. ,  The Queen's University of Belfast

发明人： Ryan Dellinger ,  Marie Eugenie Migaud ,  Philip Redpath ,  Troy Rhonemus ,  Richard Cunningham

IPC分类号： C07H19/048 ,  A61Q19/08 ,  A61Q19/00 ,  A61K8/67

摘要： Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including 1-(2′,3′,5′-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid (4a), and compositions containing the same and/or reduced derivative forms of nicotinamide riboside including 1-(2′,3′,5′-triacetyl-beta-D-ribofuranosyl)-1,4-nicotinamide (2), are provided for use in the care of treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing one or more NR, NAR, NRH, or NARH derivatives, or prodrugs or salts thereof. In further embodiments, the invention relates to methods of using one or more NR, NAR, NRH, or NARH derivatives, or prodrugs, solvates, or salts thereof, to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival and overall cell and tissue health.

公开(公告)号：US10000520B2

公开(公告)日：2018-06-19

申请号：US15461126

申请日：2017-03-16

申请人： ChromaDex Inc. ,  The Queen's University of Belfast

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Ryan Dellinger ,  Troy Rhonemus ,  Sylesh Venkataraman ,  Brian Nettles

IPC分类号： C07H19/00 ,  C07H19/048 ,  C07H1/00 ,  C07H19/04

CPC分类号： C07H19/048 ,  C07H1/00 ,  C07H19/04

摘要： The present disclosure provides nicotinate/nicotinamide riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, and synthetic processes for the preparation thereof.

公开(公告)号：US20180134743A1

公开(公告)日：2018-05-17

申请号：US15809753

申请日：2017-11-10

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： C07H19/048 ,  C07D307/20 ,  C07H19/20

摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.

公开(公告)号：US11345720B2

公开(公告)日：2022-05-31

申请号：US17551592

申请日：2021-12-15

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： C07H19/207 ,  C07H19/048 ,  C07D307/20 ,  C07H19/20 ,  C07H19/04

摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.

公开(公告)号：US11274117B2

公开(公告)日：2022-03-15

申请号：US17246090

申请日：2021-04-30

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H19/048 ,  C07D307/20 ,  C07H19/20 ,  C07H19/04

摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.

公开(公告)号：US20180134742A1

公开(公告)日：2018-05-17

申请号：US15809731

申请日：2017-11-10

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： C07H19/048

CPC分类号： C07H19/048 ,  C07B2200/13 ,  C07D307/20 ,  C07H19/04 ,  C07H19/20

摘要： The present disclosure provides novel crystalline forms of nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, modified derivatives thereof, and phosphorylated analogs thereof, or salts, solvates, or prodrugs thereof, and methods of preparation thereof.