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    Method for synthesizing peptide containing N-substituted amino acid
    2.
    发明授权
    Method for synthesizing peptide containing N-substituted amino acid 有权

    公开(公告)号：US11787836B2

    公开(公告)日：2023-10-17

    申请号：US17976942

    申请日：2022-10-31

    申请人： Chugai Seiyaku Kabushiki Kaisha

    发明人： Kenichi Nomura ,  Terushige Muraoka ,  Mikimasa Tanada ,  Takashi Emura

    IPC分类号： C07K11/02 ,  C07K1/06

    CPC分类号： C07K1/061 ,  C07K11/02

    摘要： Methods of producing a peptide containing an N-substituted amino acid or N-substituted amino acid analog of the present invention include the steps of: preparing an Fmoc-protected amino acid, an Fmoc-protected amino acid analog, or an Fmoc-protected peptide; deprotecting a protecting group which have an Fmoc skeleton of the Fmoc-protected amino acid and such by using a base; and forming an amide bond by adding a new Fmoc-protected amino acid and such; and when the peptide is produced by a solid-phase method, the obtained peptide is cleaved off from the solid phase under conditions of weaker acidity than TFA. Furthermore, at least one side chain of the obtained peptide has a protecting group that is not deprotected under basic conditions and is deprotected under conditions of weaker acidity than TFA.

    Method for synthesizing peptide containing N-substituted amino acid
    6.
    发明授权
    Method for synthesizing peptide containing N-substituted amino acid 有权

    公开(公告)号：US11542299B2

    公开(公告)日：2023-01-03

    申请号：US16619388

    申请日：2018-06-08

    申请人： Chugai Seiyaku Kabushiki Kaisha

    发明人： Kenichi Nomura ,  Terushige Muraoka ,  Mikimasa Tanada ,  Takashi Emura

    IPC分类号： C07K11/02 ,  C07K1/06

    摘要： Methods of producing a peptide containing an N-substituted amino acid or N-substituted amino acid analog of the present invention include the steps of: preparing an Fmoc-protected amino acid, an Fmoc-protected amino acid analog, or an Fmoc-protected peptide; deprotecting a protecting group which have an Fmoc skeleton of the Fmoc-protected amino acid and such by using a base; and forming an amide bond by adding a new Fmoc-protected amino acid and such; and when the peptide is produced by a solid-phase method, the obtained peptide is cleaved off from the solid phase under conditions of weaker acidity than TFA. Furthermore, at least one side chain of the obtained peptide has a protecting group that is not deprotected under basic conditions and is deprotected under conditions of weaker acidity than TFA.