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    METHOD OF SOLUBILIZING POORLY SOLUBLE/INSOLUBLE ACTIVE MATERIAL THROUGH FORMATION OF OLIGOMER COMPOSITE
    1.
    发明申请
    METHOD OF SOLUBILIZING POORLY SOLUBLE/INSOLUBLE ACTIVE MATERIAL THROUGH FORMATION OF OLIGOMER COMPOSITE 有权
    通过形成低聚物复合材料溶解不溶性/不溶性活性材料的方法

    公开(公告)号：US20120219604A1

    公开(公告)日：2012-08-30

    申请号：US13505011

    申请日：2010-10-15

    申请人： Chul-Hwan Kim ,  Seung-Hak Ko ,  Jae-Seong Shim ,  Eun-Kyoung Kwon ,  Yong-Han Choi

    发明人： Chul-Hwan Kim ,  Seung-Hak Ko ,  Jae-Seong Shim ,  Eun-Kyoung Kwon ,  Yong-Han Choi

    IPC分类号： A61K9/48

    CPC分类号： C08J3/126 ,  A61K31/00 ,  A61K31/19 ,  A61K31/201 ,  A61K31/355 ,  A61K31/385 ,  A61K31/52 ,  A61K36/16 ,  A61K36/25 ,  C07C57/03 ,  C08L1/02 ,  C08L1/286 ,  C08L3/02 ,  C08L5/00 ,  C08L5/04 ,  C08L5/06 ,  C08L5/08 ,  C08L5/12

    摘要： Provided is a method of solubilizing a poorly soluble/insoluble active material through formation of an oligomer composite, in which a structure having a hydrophobic cavity structure is formed by using oligomers derived from two types of hydrophilic natural polymers and a poorly soluble/insoluble component is encapsulated in the cavity structure, and thus, self-aggregation of the poorly soluble/insoluble material is prevented and simultaneously, thermodynamic stability increases to effectively solubilize the poorly soluble/insoluble material. According to the constitution of the present invention, the method may include a first operation of preparing an oligomer composite having a cavity structure formed therein by mixing and dissolving oligomers derived from two types of hydrophilic natural polymers in water, and a second operation of adding a poorly soluble/insoluble material to the oligomer composite to encapsulate the poorly soluble/insoluble material in the hydrophobic cavity structure of the oligomer composite.

    摘要翻译： 提供了通过形成低聚物复合物来溶解难溶性/不溶性活性物质的方法，其中通过使用衍生自两种亲水性天然聚合物的低聚物和难溶性/不溶性组分形成具有疏水空腔结构的结构 封装在空腔结构中，因此防止了难溶性/不溶性材料的自聚集，并且同时热力学稳定性增加，以有效溶解难溶性/不溶性材料。 根据本发明的结构，该方法可以包括通过将来自两种亲水性天然聚合物的低聚物混合并溶解在水中而制备其中形成有空腔结构的低聚物复合物的第一操作和第二操作， 低聚物复合材料的难溶性/不溶性材料将难溶性/不溶性材料包封在低聚物复合材料的疏水空腔结构中。