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1.
公开(公告)号:US08618071B2
公开(公告)日:2013-12-31
申请号:US13112442
申请日:2011-05-20
申请人: Yen-Ju Lin , Cheng-Tao Wu , Chung-Cheng Liu
发明人: Yen-Ju Lin , Cheng-Tao Wu , Chung-Cheng Liu
CPC分类号: A61K31/7105 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要: Provided herein is a method for detection of migratory and invasive cancer cells based on a number of marker nucleic acids differentially expressed in migratory/invasive cancer cells relative to nonmigratory/noninvasive cancer cells. Also disclosed are antisense oligonucleotides of the marker nucleic acids and uses thereof for suppressing cancer cell migration and invasion.
摘要翻译: 本文提供了一种用于基于相对于非突变/非侵入性癌细胞在迁移/浸润性癌细胞中差异表达的多种标记核酸来检测迁移性和浸润性癌细胞的方法。 还公开了标记核酸的反义寡核苷酸及其用于抑制癌细胞迁移和侵袭的用途。
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公开(公告)号:US5108919A
公开(公告)日:1992-04-28
申请号:US284281
申请日:1988-12-14
申请人: Chung-Cheng Liu , Harvey I. Miller
发明人: Chung-Cheng Liu , Harvey I. Miller
IPC分类号: C12N15/09 , C07K14/00 , C07K14/64 , C12N1/21 , C12N9/60 , C12N9/80 , C12N15/55 , C12N15/57 , C12P21/00 , C12R1/19
CPC分类号: C07K14/64 , C07K14/00 , C12N9/60 , C07K2319/036 , C07K2319/75 , C07K2319/95
摘要: A ubiquitin hydrolase is provided having a purity of at least 70% homogeneity based on the weight of the total protein in the composition. Also provided are DNA sequences encoding ubiquitin hydrolases, as well as expression systems for their recombinant production. Processes are provided for purification of a ubiquitin hydrolase from eukaryotes and for its use in recovering any desired polypeptide free from its fusion at its N-terminus with ubiquitin.
摘要翻译: 提供泛蛋白水解酶,其基于组合物中总蛋白质的重量具有至少70%的纯度至少70%的纯度。 还提供了编码泛素水解酶的DNA序列,以及用于其重组生产的表达系统。 提供了从真核生物纯化泛素水解酶的方法,并且其用于在其N-末端用泛素回收任何无融合物的所需多肽。
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公开(公告)号:US07941278B2
公开(公告)日:2011-05-10
申请号:US11617038
申请日:2006-12-28
申请人: Yu-Ching Chang , Yu-Yu Lin , Shiu-Chieh Lan , Cheng-Tao Wu , Chung-Cheng Liu
发明人: Yu-Ching Chang , Yu-Yu Lin , Shiu-Chieh Lan , Cheng-Tao Wu , Chung-Cheng Liu
IPC分类号: G06F7/00
CPC分类号: C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/10 , G06F19/16 , G06F19/18 , G06F19/22
摘要: Disclosed are methods of identifying microRNA motifs or microRNA precursors for a target gene or a set of target genes. Also disclosed are related computer-readable media.
摘要翻译: 公开了鉴定靶基因或一组靶基因的微小RNA基序或微小RNA前体的方法。 还公开了相关的计算机可读介质。
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公开(公告)号:US5156968A
公开(公告)日:1992-10-20
申请号:US210909
申请日:1988-06-24
申请人: Chung-Cheng Liu
发明人: Chung-Cheng Liu
CPC分类号: C12N9/60 , C07K14/00 , C07K14/64 , C07K2319/00 , C07K2319/036 , C07K2319/75 , C07K2319/95
摘要: Ubiquitin hydrolase is provided having a purity of at least 70% homogeneity based on the weight of the total protein in the composition, which hydrolase hydrolyzes a ubiquitin-polypeptide conjugate at the amide bond linking the ubiquitin and polypeptide, thereby yielding intact polypeptide with an unconjugated, mature N-terminus. Also provided are DNA sequences encoding such ubiquitin hydrolase, as well as expression systems for its recombinant production. Processes are provided for purification of ubiquitin hydrolase from eukaryotes and for its use in recovering any desired polypeptide free from its fusion at its N-terminus with ubiquitin.
摘要翻译: 提供泛素水解酶,其纯度基于组合物中总蛋白质的重量至少70%的均匀性,该水解酶在连接泛素和多肽的酰胺键处水解泛素 - 多肽缀合物,由此产生具有未缀合的完整多肽 ,成熟N末端。 还提供了编码这种泛素水解酶的DNA序列,以及用于其重组生产的表达系统。 提供了用于从真核生物纯化泛素水解酶的方法,并且其用于在其N-末端用泛素回收任何无融合物的所需多肽。
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5.
公开(公告)号:US20110288150A1
公开(公告)日:2011-11-24
申请号:US13112442
申请日:2011-05-20
申请人: Yen-Ju Lin , Cheng-Tao Wu , Chung-Cheng Liu
发明人: Yen-Ju Lin , Cheng-Tao Wu , Chung-Cheng Liu
IPC分类号: A61K31/7105 , A61P35/04 , C12Q1/68 , C12N5/09 , C07H21/02
CPC分类号: A61K31/7105 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要: Provided herein is a method for detection of migratory and invasive cancer cells based on a number of marker nucleic acids differentially expressed in migratory/invasive cancer cells relative to nonmigratory/noninvasive cancer cells. Also disclosed are antisense oligonucleotides of the marker nucleic acids and uses thereof for suppressing cancer cell migration and invasion.
摘要翻译: 本文提供了一种用于基于相对于非突变/非侵入性癌细胞在迁移/浸润性癌细胞中差异表达的多种标记核酸来检测迁移性和浸润性癌细胞的方法。 还公开了标记核酸的反义寡核苷酸及其用于抑制癌细胞迁移和侵袭的用途。
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公开(公告)号:US20070275392A1
公开(公告)日:2007-11-29
申请号:US11617038
申请日:2006-12-28
申请人: Yu-Ching Chang , Yu-Yu Lin , Shiu-Chieh Lan , Cheng-Tao Wu , Chung-Cheng Liu
发明人: Yu-Ching Chang , Yu-Yu Lin , Shiu-Chieh Lan , Cheng-Tao Wu , Chung-Cheng Liu
IPC分类号: C12Q1/68
CPC分类号: C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/10 , G06F19/16 , G06F19/18 , G06F19/22
摘要: Disclosed are methods of identifying microRNA motifs or microRNA precursors for a target gene or a set of target genes. Also disclosed are related computer-readable media.
摘要翻译: 公开了鉴定靶基因或一组靶基因的微小RNA基序或微小RNA前体的方法。 还公开了相关的计算机可读介质。
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7.
公开(公告)号:US5262322A
公开(公告)日:1993-11-16
申请号:US694522
申请日:1991-04-30
申请人: Chung-Cheng Liu , Harvey I. Miller
发明人: Chung-Cheng Liu , Harvey I. Miller
CPC分类号: C07K14/00 , C07K14/64 , C12N9/60 , C07K2319/036 , C07K2319/75 , C07K2319/95
摘要: A ubiquitin hydrolase is provided having a purity of at least 70% homogeneity based on the weight of the total protein in the composition. Also provided are DNA sequences encoding ubiquitin hydrolases, as well as expression systems for their recombinant production. Processes are provided for purification of a ubiquitin hydrolase from eukaryotes and for its use in recovering any desired polypeptide free from its fusion at its N-terminus with ubiquitin.
摘要翻译: 提供泛蛋白水解酶,其基于组合物中总蛋白质的重量具有至少70%的纯度至少70%的纯度。 还提供了编码泛素水解酶的DNA序列,以及用于其重组生产的表达系统。 提供了从真核生物纯化泛素水解酶的方法,并且其用于在其N-末端用泛素回收任何无融合物的所需多肽。
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公开(公告)号:US08014956B2
公开(公告)日:2011-09-06
申请号:US11617042
申请日:2006-12-28
申请人: Yu-Ching Chang , Yu-Yu Lin , Shiu-Chieh Lan , Cheng-Tao Wu , Chung-Cheng Liu
发明人: Yu-Ching Chang , Yu-Yu Lin , Shiu-Chieh Lan , Cheng-Tao Wu , Chung-Cheng Liu
IPC分类号: G06F7/00
CPC分类号: C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/10 , G06F19/16 , G06F19/18 , G06F19/22
摘要: Disclosed are methods of identifying microRNA motifs or microRNA precursors for a target gene or a set of target genes. Also disclosed are related computer-readable media.
摘要翻译: 公开了鉴定靶基因或一组靶基因的微小RNA基序或微小RNA前体的方法。 还公开了相关的计算机可读介质。
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公开(公告)号:US20070218479A1
公开(公告)日:2007-09-20
申请号:US11617042
申请日:2006-12-28
申请人: Yu-Ching Chang , Yu-Yu Lin , Shiu-Chieh Lan , Cheng-Tao Wu , Chung-Cheng Liu
发明人: Yu-Ching Chang , Yu-Yu Lin , Shiu-Chieh Lan , Cheng-Tao Wu , Chung-Cheng Liu
CPC分类号: C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/10 , G06F19/16 , G06F19/18 , G06F19/22
摘要: Disclosed are methods of identifying microRNA motifs or microRNA precursors for a target gene or a set of target genes. Also disclosed are related computer-readable media
摘要翻译: 公开了鉴定靶基因或一组靶基因的微小RNA基序或微小RNA前体的方法。 还公开了相关的计算机可读介质
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公开(公告)号:US20050017619A1
公开(公告)日:2005-01-27
申请号:US10622732
申请日:2003-07-21
申请人: Sheng-Chih Wan , Shen-Chun Wu , Chung-Cheng Liu
发明人: Sheng-Chih Wan , Shen-Chun Wu , Chung-Cheng Liu
CPC分类号: H01J61/305 , H01J61/35
摘要: A modified high-brightness flat lamp structure comprises a reflecting plate, a plurality of UV light sources and a transparent substrate. The reflecting plate has titanium dioxide and macromolecular polymer coated thereon. The transparent substrate has macromolecular polymer and fluorescent powder coated thereon. The UV light sources are arranged in the reflecting plate. The transparent substrate covers the reflecting plate. UV light emitted by the UV light sources and reflected by the reflecting plate will thus excite the fluorescent powder layer to radiate high-brightness visible light.
摘要翻译: 改进的高亮度平板灯结构包括反射板,多个UV光源和透明基板。 反射板上涂有二氧化钛和高分子聚合物。 透明基板上涂有高分子聚合物和荧光粉末。 UV光源设置在反射板中。 透明基板覆盖反射板。 由UV光源发射并被反射板反射的UV光将因此激发荧光粉层以辐射高亮度可见光。
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