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1.发明授权Use of a corn peptidic hydrolyzate as an active agent stiimulating hair growth 有权使用玉米肽水解产物作为刺激毛发生长的活性剂公开(公告)号：US09259381B2
公开(公告)日：2016-02-16
申请号：US13858262
申请日：2013-04-08
CPC分类号： A61K8/645 , A61K8/97 , A61K36/899 , A61Q5/00 , A61Q7/00
摘要： The invention relates to a cosmetic treatment method intended to stimulate hair growth, restore hair growth, and/or limit hair loss. The cosmetic treatment method includes providing a composition comprising at least one corn (Zea mays L.) peptidic hydrolyzate, as an active agent to stimulate hair growth, or reduce hair loss and applying it topically to an area having hair follicles.
摘要翻译： 本发明涉及一种旨在刺激毛发生长，恢复毛发生长和/或限制脱发的美容治疗方法。 美容处理方法包括提供包含至少一种玉米（Zea mays L.）肽水解产物的组合物作为活性剂以刺激毛发生长，或减少脱发并将其局部施用于具有毛囊的区域。
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2.发明授权Peptides involved in the SCF c-Kit signaling pathway and compositions comprising same 有权涉及SCF c-Kit信号通路的肽和包含其的组合物公开(公告)号：US08962565B2
公开(公告)日：2015-02-24
申请号：US13982386
申请日：2012-01-30
IPC分类号： A61K38/08 , A61K8/64 , C07K7/06 , C07K7/08 , A61Q17/04 , A61Q19/02 , A61Q19/08 , C07K5/113 , A61Q19/00
CPC分类号： A61K8/64 , A61K38/08 , A61Q17/04 , A61Q19/004 , A61Q19/02 , A61Q19/08 , C07K5/1021 , C07K7/06 , C07K7/08
摘要： Peptide compounds of general formula (I) R1-(AA)n-X1—X2—X3-Asp-Leu-Lys-Lys-X4—X5-(AA)p-R2, cosmetic or pharmaceutical compositions comprising at least one peptide compound of general formula (I) in a physiologically acceptable medium, and methods for cosmetic treatment of skin are disclosed. The peptide compounds of general formula (I) were demonstrated to be agents making it possible to influence the pigmentation of the skin and skin appendages, by ensuring optimal transfer of the melanosomes to the keratinocytes, so as to make the skin tone uniform owing to an effect on the SCF/c-Kit signaling pathway. The compounds, compositions, and methods treat or attenuate age-related pigmentation defects and the effects of photoaging on the skin.
摘要翻译： 通式（I）R1-（AA）n-X1-X2-X3-Asp-Leu-Lys-Lys-X4-X5-（AA）p-R2的肽化合物，包含至少一种肽化合物的化妆品或药物组合物 通式（I）的生理学上可接受的介质，以及皮肤美容治疗方法。 证明通式（I）的肽化合物是通过确保黑素体最佳转移到角质形成细胞而使皮肤和皮肤附着物的色素沉着成为可能的原因，从而使肤色均匀 对SCF / c-Kit信号通路的作用。 化合物，组合物和方法治疗或减轻年龄相关色素沉着缺陷和光老化对皮肤的影响。
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3.发明授权Anti-aging peptides and cosmetic and/or pharmaceutical composition containing same 有权抗衰老肽和含有其的化妆品和/或药物组合物公开(公告)号：US08877713B2
公开(公告)日：2014-11-04
申请号：US13935675
申请日：2013-07-05
IPC分类号： A61K38/08 , A61K38/07 , A61K38/06 , A61Q19/08 , C07K7/06 , C07K5/08 , C07K5/10 , C07K5/083 , C07K14/47 , A61K8/64 , A61K38/00
摘要： Methods of restoring the circadian rhythm and resynchronizing the biological clock of cells are described. The methods include topically applying a topical composition comprising a cosmetically acceptable medium and an effective quantity of a peptide compound of general formula (I), R1-(AA)n-X1-Ser-Thr-Pro-X2-(AA)p-R2, to skin or skin appendages to be treated.
摘要翻译： 描述恢复昼夜节律并重新同步细胞生物钟的方法。 所述方法包括局部施用包含化妆品可接受的介质和有效量的通式（I）的肽化合物，R1-（AA）n-X1-Ser-Thr-Pro-X2-（AA）对 - R2，皮肤或皮肤附属物进行治疗。
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4.发明授权Cosmetic and/or pharmaceutical composition comprising a relieving peptidic hydrolyzate 有权包含缓和肽水解产物的化妆品和/或药物组合物公开(公告)号：US08685927B2
公开(公告)日：2014-04-01
申请号：US13264082
申请日：2010-04-15
IPC分类号： A61K38/07 , A61K38/08 , A61K8/64 , A61K8/97 , C07K5/10 , C07K7/06 , C07K4/10 , A61Q17/00 , A61Q17/04
CPC分类号： C07K5/1008 , A61K8/64 , A61K8/97 , A61K36/31 , A61K36/81 , A61K36/899 , A61K38/011 , A61K38/07 , A61K38/08 , A61K2800/522 , A61Q7/00 , A61Q17/00 , A61Q17/04 , A61Q19/004 , A61Q19/005 , C07K4/10 , C07K7/06
摘要： A cosmetic or pharmaceutical composition that includes a peptide hydrolyzate which is enriched in soothing bioactive peptide in a physiologically acceptable medium is described. Methods for applying such compositions to the skin are also described, in particular where the active principle activates 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) reductase in skin cells to treat skin irritations.
摘要翻译： 描述了包含在生理学上可接受的介质中富含舒缓生物活性肽的肽水解产物的化妆品或药物组合物。 还描述了将这些组合物施用于皮肤的方法，特别是当活性成分激活皮肤细胞中的3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶以治疗皮肤刺激时。
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5.发明申请NOVEL ACTIVATOR PEPTIDES FOR SYNTHESIZING EXTRACELLULAR MATRIX PROTEINS, AND COSMETIC COMPOSITIONS INCLUDING SAME 有权用于合成细胞外基质蛋白的新型活化剂肽和包括其的化妆品组合物公开(公告)号：US20140044655A1
公开(公告)日：2014-02-13
申请号：US13984568
申请日：2012-02-17
摘要： This invention relates to new peptides activating extracellular matrix protein synthesis in the skin.This invention also relates to a cosmetic composition comprising such peptides as an active agent and the use of such a composition for increasing the extracellular matrix protein expression, delaying the appearance of or reducing wrinkles, sagging and loss of skin volume, and dehydration of the skin.The invention finally relates to cosmetic care methods intended to delay or treat cutaneous signs of aging and photoaging.
摘要翻译： 本发明涉及激活皮肤中细胞外基质蛋白合成的新肽。 本发明还涉及包含这种肽作为活性剂的化妆品组合物，以及这种组合物用于增加细胞外基质蛋白质表达，延缓皱纹出现或减少皱纹，下垂和皮肤体积减少以及皮肤脱水的用途 。 本发明最终涉及旨在延缓或治疗老化和光老化皮肤征象的美容护理方法。
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6.发明申请COSMETIC AND/OR PHARMACEUTICAL COMPOSITION COMPRISING A YEAST PEPTIDE HYDROLYSATE AND USE OF THE YEAST PEPTIDE HYDROLYSATE AS AN ACTIVE AGENT FOR STRENGTHENING HAIR 有权化妆品和/或药物组合物，包括YEAST PEPTIDE HYDROLYYATEATE，以及使用YEAST PEPTIDE HYDROLYZATE作为活性剂来增强头发公开(公告)号：US20130296251A1
公开(公告)日：2013-11-07
申请号：US13843452
申请日：2013-03-15
摘要： A method of attenuating or preventing hair loss in a human in need thereof comprising applying to the human in need thereof a composition comprising an effective amount of a hair-loss attenuating peptide hydrolysate and a cosmetically acceptable carrier.
摘要翻译： 一种在有需要的人中减弱或预防脱发的方法包括向有需要的人施用包含有效量的脱发减毒肽水解产物和美容上可接受的载体的组合物。
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7.发明授权公开(公告)号：US08530623B2
公开(公告)日：2013-09-10
申请号：US13262451
申请日：2010-04-01
CPC分类号： C07K5/1021 , A61K8/64 , A61Q19/02 , A61Q19/08 , C07K7/06
摘要： The present invention relates to depigmenting, lightening and/or whitening peptidic compounds of general formula (I) R1—X1—X2-Asp-Cys-Arg-X3—X4-(AA)p-R2. In addition, the present invention relates to, on the one hand, a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I), in a cosmetically or dermatologically acceptable medium and, on the other hand, its utilization to depigment, lighten and/or whiten the skin and prevent or treat hyperpigmentation blemishes as well as cutaneous signs due to photo-aging. Lastly, the invention applies to a cosmetic treatment method utilizing said peptidic compounds.
摘要翻译： 本发明涉及通式（Ⅰ）R1-X1-X2-Asp-Cys-Arg-X3-X4-（AA）p-R2的脱色，减亮和/或增白肽化合物。 此外，本发明一方面涉及包含至少一种通式（I）的肽的化妆品或药物组合物，在化妆品或皮肤病学可接受的介质中，另一方面涉及其用于脱色， 减轻和/或增白皮肤，防止或治疗色素沉着过度的瑕疵以及由于光老化引起的皮肤征象。 最后，本发明适用于利用所述肽化合物的美容治疗方法。
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8.发明授权Activating peptide of the synthesis of aquaporins and cosmetic and/or pharmaceutical composition containing it 有权激活水通道蛋白合成肽和含有它的化妆品和/或药物组合物公开(公告)号：US08450456B2
公开(公告)日：2013-05-28
申请号：US12808266
申请日：2008-12-17
IPC分类号： C07K5/10
CPC分类号： C07K4/00 , A61K8/64 , A61K38/00 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C07K5/06 , C07K5/08 , C07K5/0819 , C07K5/0823 , C07K5/1021
摘要： The present invention concerns a peptide of the general formula (I):R1-(AA)n-X1—X2—X3-Pro-X4—X5—X7-(AA)p-R2, capable of activating the synthesis of proteins of the family of aquaporins.The present invention also concerns a cosmetic, nutraceutical or pharmaceutical composition, comprising a peptide of general formula (I) as active principle. The invention also relates to the use of this new active principle in a cosmetic or nutraceutical composition, intended to improve the moisturizing and the barrier function of the epidermis and intended to stimulate cutaneous regeneration. The invention also relates to the use of this new active principle to realize a pharmaceutical composition, and in particular a dermatological composition, intended to regulate and/or stimulate the activity of the aquaporins and to thus treat the pathological dryness of the skin or mucosa. The invention also relates to a method of cosmetic treatment intended to prevent or combat against dryness of the skin and mucosa, and the manifestations of cutaneous ageing.
摘要翻译： 本发明涉及通式（I）的肽：R1-（AA）n-X1-X2-X3-Pro-X4-X5-X7-（AA）p-R2，其能够活化蛋白质的合成 水通道蛋白家族。 本发明还涉及包含通式（I）的肽作为活性成分的化妆品，营养药物或药物组合物。 本发明还涉及这种新的活性成分在化妆品或营养组合物中的用途，其旨在改善表皮的保湿和屏障功能并且旨在刺激皮肤再生。 本发明还涉及这种新的活性成分用于实现旨在调节和/或刺激水通道蛋白的活性并因此治疗皮肤或粘膜的病理干燥的药物组合物，特别是皮肤病学组合物的用途。 本发明还涉及旨在预防或防止皮肤和粘膜干燥以及皮肤老化表现的美容治疗方法。
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9.发明授权Pharmaceutical and/or cosmetic composition containing an active antioxydant principle and cell energy activator 有权含有活性抗氧化剂原理和细胞能活化剂的药物和/或化妆品组合物公开(公告)号：US08440789B2
公开(公告)日：2013-05-14
申请号：US12597862
申请日：2008-04-23
摘要： A cosmetic or pharmaceutical composition, and particularly dermatological composition, comprising, in a physiologically adapted medium, as active principle, polypeptides or peptides, and methods of administering a composition capable of increasing cell energy and to protect the skin from oxidative damage. Also, a cosmetic treatment procedure aimed at protecting the skin and the skin appendages from external aggressions and to combat skin aging.
摘要翻译： 在生理适应的介质中包含作为活性成分，多肽或肽的化妆品或药物组合物，特别是皮肤病学组合物，以及施用能够增加细胞能量并保护皮肤免受氧化损伤的组合物的方法。 另外，一种旨在保护皮肤和皮肤附属物免受外部侵害并防止皮肤老化的美容治疗程序。
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10.发明授权Cosmetic and/or pharmaceutical composition comprising as an active principle at least one peptide and use of this peptide 有权包含作为活性成分的至少一种肽和使用该肽的化妆品和/或药物组合物公开(公告)号：US08222368B2
公开(公告)日：2012-07-17
申请号：US12446958
申请日：2007-10-26
摘要： A cosmetic and/or pharmaceutical composition contains, as an active ingredient, at least one peptide from SEQ ID No1 to SEQ ID No8. The use of this peptide as an active ingredient for preparing compositions for inducing, increasing or restoring melanin synthesis in melanocytes of the skin or dermal papilla is also disclosed.
摘要翻译： 化妆品和/或药物组合物含有SEQ ID No1至SEQ ID No8的至少一种肽作为活性成分。 还公开了该肽作为活性成分用于制备用于诱导，增加或恢复皮肤或真皮乳头的黑素细胞中的黑色素合成的组合物的用途。
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