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公开(公告)号:US20070016078A1
公开(公告)日:2007-01-18
申请号:US11295162
申请日:2005-12-06
申请人: Clifford Hoyt , James Mansfield , Richard Levenson
发明人: Clifford Hoyt , James Mansfield , Richard Levenson
IPC分类号: A61B6/00
CPC分类号: A61B5/0059 , A61B5/0073 , A61B5/1075 , A61B2503/40 , A61B2562/0238 , A61B2562/0242 , G01N21/4795 , G01N21/6428 , G01N21/6456 , G01N21/763 , G01N2021/6419 , G01N2021/6421
摘要: Disclosed are methods and systems for determining information about a position of the entity within the sample using spectral techniques. For example, the sample may be a living animal, such as a mouse, and the embedded object may be a tumor.
摘要翻译: 公开了用于使用光谱技术确定样本中实体的位置的信息的方法和系统。 例如,样品可以是活的动物,例如小鼠,并且嵌入的物体可以是肿瘤。
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公开(公告)号:US20060118742A1
公开(公告)日:2006-06-08
申请号:US11295701
申请日:2005-12-06
申请人: Richard Levenson , Clifford Hoyt
发明人: Richard Levenson , Clifford Hoyt
IPC分类号: G01V8/00
CPC分类号: A61B5/0059 , A61B5/0073 , A61B5/1075 , A61B2503/40 , A61B2562/0238 , A61B2562/0242 , G01N21/4795 , G01N21/6428 , G01N21/6456 , G01N21/763 , G01N2021/6419 , G01N2021/6421
摘要: Disclosed are methods and systems for: (i) positioning a specimen inside an optical measurement system according to a reference image of the specimen indicative of its position and orientation during an earlier measurement using the optical measurement system; and (ii) measuring radiation emitted from the positioned specimen to provide information about an object embedded in the specimen.
摘要翻译: 公开了以下方法和系统:(i)根据使用光学测量系统的较早测量期间指示其位置和取向的样本的参考图像将样本定位在光学测量系统内; 和(ii)测量从定位的样品发射的辐射,以提供关于嵌入在样品中的物体的信息。
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公开(公告)号:US20080074644A1
公开(公告)日:2008-03-27
申请号:US11861060
申请日:2007-09-25
申请人: Richard Levenson , Clifford Hoyt
发明人: Richard Levenson , Clifford Hoyt
IPC分类号: G01N1/00
CPC分类号: G06K9/6289 , G01N21/23 , G01N21/31 , G01N21/6456 , G01N2021/6417 , G01N2021/6493
摘要: Disclosed herein are methods and apparatus for obtaining at least one absorption image and at least one birefringence image of a stained sample.
摘要翻译: 本文公开了用于获得染色样品的至少一个吸收图像和至少一个双折射图像的方法和装置。
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公开(公告)号:US20060245631A1
公开(公告)日:2006-11-02
申请号:US11342272
申请日:2006-01-27
申请人: Richard Levenson , Clifford Hoyt , Kirk Gossage
发明人: Richard Levenson , Clifford Hoyt , Kirk Gossage
IPC分类号: G06K9/00
CPC分类号: G06K9/6212 , G06K9/00127 , G06K9/6217 , G06K9/6247 , G06K9/628 , G06K9/6284
摘要: Methods are disclosed for classifying different parts of a sample into respective classes based on an image stack that includes one or more images.
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公开(公告)号:US20080074649A1
公开(公告)日:2008-03-27
申请号:US11861057
申请日:2007-09-25
申请人: Richard Levenson , Clifford Hoyt
发明人: Richard Levenson , Clifford Hoyt
IPC分类号: G01N21/00
CPC分类号: G06K9/6289 , G01N21/23 , G01N21/31 , G01N21/6456 , G01N2021/6417 , G01N2021/6493
摘要: Disclosed herein are methods and apparatus for obtaining at least one non-birefringence image and at least one birefringence image of a stained sample, and classifying regions of the stained sample into a plurality of classes based on the at least one non-birefringence image and the at least one birefringence image.
摘要翻译: 本文公开了用于获得染色样品的至少一个非双折射图像和至少一个双折射图像的方法和装置,并且基于至少一个非双折射图像将染色样品的区域分类为多个等级, 至少一个双折射图像。
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公开(公告)号:US08639043B2
公开(公告)日:2014-01-28
申请号:US13600351
申请日:2012-08-31
CPC分类号: G06K9/6212 , G06K9/00127 , G06K9/6217 , G06K9/6247 , G06K9/628 , G06K9/6284
摘要: Methods are disclosed for classifying different parts of a sample into respective classes based on an image stack that includes one or more images.
摘要翻译: 公开了用于基于包括一个或多个图像的图像堆叠将样本的不同部分分类为相应类别的方法。
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公开(公告)号:US08385615B2
公开(公告)日:2013-02-26
申请号:US12390690
申请日:2009-02-23
IPC分类号: G06K9/00 , G06K9/46 , G06K9/62 , G06K9/66 , G01N33/48 , G01N21/64 , G01J3/00 , G01J1/00 , G01J1/58 , G01T1/00 , G21G4/00 , A61B5/05 , A61B6/00
CPC分类号: G01N33/4833 , A61B5/0059 , B82Y5/00 , B82Y10/00 , G01J3/32 , G01J3/4406 , G01J3/453 , G01N21/255 , G01N21/6486 , G01N2201/062 , G01N2201/125
摘要: The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components.
摘要翻译: 本发明的特征在于一种方法,包括:(i)响应于样品的照明,提供关于来自包含深层组织的样品中的不同空间位置的光的光谱解析信息,其中所述光包括来自样品中不同组分的贡献; (ii)将所述不同空间位置中的至少一些中的每一个的所述光谱解析信息分解为与所述样本中的至少一些组件相关联的频谱估计的贡献; 和(iii)基于分解构建样品的深层组织图像,以优先显示所选择的组分之一。
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公开(公告)号:US20090324051A1
公开(公告)日:2009-12-31
申请号:US12486718
申请日:2009-06-17
申请人: Clifford C. Hoyt , Richard Levenson
发明人: Clifford C. Hoyt , Richard Levenson
CPC分类号: G06K9/00147 , G01N1/30
摘要: Methods are disclosed that include: (a) applying a first stain to a first sample having a plurality of regions, where the first stain selectively binds to only a first subset of the regions of the first sample; (b) applying a second stain to the first sample, where the second stain binds to a second set of regions of the first sample; (c) obtaining an image of the first sample, and analyzing the image to obtain a first component image corresponding substantially only to spectral contributions from the first stain, and a second component image corresponding substantially only to spectral contributions from the second stain; and (d) training a classifier to identify regions of a second sample based on information derived from the first and second component images, the identified regions corresponding to the first subset of regions of the first sample.
摘要翻译: 公开的方法包括:(a)将第一染色施加到具有多个区域的第一样品,其中第一染色选择性地仅结合第一样品的区域的第一子集; (b)对第一样品施加第二染色,其中第二染色结合第一样品的第二组区域; (c)获得第一样本的图像,并且分析图像以获得基本上仅对来自第一染色的光谱贡献的第一分量图像和基本上仅对应于来自第二染色的光谱贡献的第二分量图像; 和(d)训练分类器,以基于从第一和第二分量图像导出的信息识别第二样本的区域,所识别的区域对应于第一样本的区域的第一子集。
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公开(公告)号:US08379962B2
公开(公告)日:2013-02-19
申请号:US13493206
申请日:2012-06-11
申请人: Clifford C. Hoyt , Richard Levenson
发明人: Clifford C. Hoyt , Richard Levenson
CPC分类号: G06K9/00147 , G01N1/30
摘要: Methods are disclosed that include: (a) applying a first stain to a first sample having a plurality of regions, where the first stain selectively binds to only a first subset of the regions of the first sample; (b) applying a second stain to the first sample, where the second stain binds to a second set of regions of the first sample; (c) obtaining an image of the first sample, and analyzing the image to obtain a first component image corresponding substantially only to spectral contributions from the first stain, and a second component image corresponding substantially only to spectral contributions from the second stain; and (d) training a classifier to identify regions of a second sample based on information derived from the first and second component images, the identified regions corresponding to the first subset of regions of the first sample.
摘要翻译: 公开的方法包括:(a)将第一染色施加到具有多个区域的第一样品,其中第一染色选择性地仅结合第一样品的区域的第一子集; (b)对第一样品施加第二染色,其中第二染色结合第一样品的第二组区域; (c)获得第一样本的图像,并且分析图像以获得基本上仅对来自第一染色的光谱贡献的第一分量图像和基本上仅对应于来自第二染色的光谱贡献的第二分量图像; 和(d)训练分类器,以基于从第一和第二分量图像导出的信息识别第二样本的区域,所识别的区域对应于第一样本的区域的第一子集。
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公开(公告)号:US07873407B2
公开(公告)日:2011-01-18
申请号:US11295701
申请日:2005-12-06
申请人: Richard Levenson , Clifford C. Hoyt
发明人: Richard Levenson , Clifford C. Hoyt
CPC分类号: A61B5/0059 , A61B5/0073 , A61B5/1075 , A61B2503/40 , A61B2562/0238 , A61B2562/0242 , G01N21/4795 , G01N21/6428 , G01N21/6456 , G01N21/763 , G01N2021/6419 , G01N2021/6421
摘要: Disclosed are methods and systems for: (i) positioning a specimen inside an optical measurement system according to a reference image of the specimen indicative of its position and orientation during an earlier measurement using the optical measurement system; and (ii) measuring radiation emitted from the positioned specimen to provide information about an object embedded in the specimen.
摘要翻译: 公开了以下方法和系统:(i)根据使用光学测量系统的较早测量期间指示其位置和取向的样本的参考图像将样本定位在光学测量系统内; 和(ii)测量从定位的样品发射的辐射,以提供关于嵌入在样品中的物体的信息。
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