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    SAMPLE IMAGING AND CLASSIFICATION
    1.
    发明申请
    SAMPLE IMAGING AND CLASSIFICATION 有权
    样本成像和分类

    公开(公告)号：US20080074649A1

    公开(公告)日：2008-03-27

    申请号：US11861057

    申请日：2007-09-25

    申请人： Richard Levenson ,  Clifford Hoyt

    发明人： Richard Levenson ,  Clifford Hoyt

    IPC分类号： G01N21/00

    CPC分类号： G06K9/6289 ,  G01N21/23 ,  G01N21/31 ,  G01N21/6456 ,  G01N2021/6417 ,  G01N2021/6493

    摘要： Disclosed herein are methods and apparatus for obtaining at least one non-birefringence image and at least one birefringence image of a stained sample, and classifying regions of the stained sample into a plurality of classes based on the at least one non-birefringence image and the at least one birefringence image.

    摘要翻译： 本文公开了用于获得染色样品的至少一个非双折射图像和至少一个双折射图像的方法和装置，并且基于至少一个非双折射图像将染色样品的区域分类为多个等级， 至少一个双折射图像。

    Visualizing Birefringent Structures in Samples
    6.
    发明申请
    Visualizing Birefringent Structures in Samples 有权
    可视化样品中的双折射结构

    公开(公告)号：US20090135422A1

    公开(公告)日：2009-05-28

    申请号：US12273299

    申请日：2008-11-18

    申请人： Peter Miller ,  David Fletcher-Holmes ,  Cathy M. Boutin ,  Clifford Hoyt

    发明人： Peter Miller ,  David Fletcher-Holmes ,  Cathy M. Boutin ,  Clifford Hoyt

    IPC分类号： G01J4/00

    CPC分类号： G01J4/04 ,  G01N21/23

    摘要： Apparatus and methods are disclosed for viewing low-birefringence structures within samples directly, with the eye, in real-time. The sample is placed between an entrance polarizer and analyzer polarizer, the transmission state of one of which is changed dynamically to create a modulated view of the scene; against this background, birefringent structures are visible because of their different appearance when modulated. Modulation rates of 4 or more states per second; use of 4 or more states, or even a continuum of states, which lie substantially on a latitude line on the Poincare sphere; and orientation of the polarization components to produce a uniform background; produce a clear view that does not produce operator fatigue. Broad-band wavelength operation spanning 50 nm or more, or the whole visible range, is achieved, and it is compatible with integration into other microscopy modes such as Hoffman relief contrast.

    摘要翻译： 公开了用于在眼睛内实时观察样品内的低双折射结构的装置和方法。 将样品放置在入射偏振器和分析器偏振器之间，其中一个的传输状态被动态地改变以产生场景的调制视图; 在这种背景下，双折射结构是可见的，因为它们在调制时的外观不同。 每秒4个或更多个状态的调制率; 使用4个或更多的状态，甚至是连续的状态，它们基本上位于庞加莱球体上的纬度线上; 和偏振分量的取向产生均匀的背景; 产生不会产生操作员疲劳的清晰视图。 实现跨越50nm或更大，或整个可见光范围的宽带波长操作，并且与其他显微镜模式（例如Hoffman浮雕对比度）的集成兼容。

    Surface measurement of in-vivo subjects using spot projector
    7.
    发明申请
    Surface measurement of in-vivo subjects using spot projector 有权
    使用投影仪进行体内受试者的表面测量

    公开(公告)号：US20080198355A1

    公开(公告)日：2008-08-21

    申请号：US12005510

    申请日：2007-12-27

    申请人： Peter Domenicali ,  Clifford Hoyt ,  Peter Miller

    发明人： Peter Domenicali ,  Clifford Hoyt ,  Peter Miller

    IPC分类号： G01C11/12

    CPC分类号： G01B11/24 ,  G01N21/763 ,  G01N2021/6417

    摘要： The invention provides for surface mapping of in-vivo imaging subjects using a single camera and an illuminator that projects a plurality of targets such as spots on the subject. By limiting the depth-of-field of the camera lens, or of the illuminator optics, or both, a spatial plane is defined in which the spots are most sharply in focus. Controlled displacement of this plane relative to the subject is achieved through movement of the mechanical stage on which a subject is placed; or through movement of the best-focus plane by adjustment of the camera, lens, or illuminator optics. Images are taken at several relative positions of the best-focus plane and the subject, and the height of individual points on the subject is determined through analysis of focus, given the known displacements. A mesh or other surface can be constructed from individual point locations, to provide a surface map of the subject. Accuracy of 0.5 mm can be readily attained for mice and similarly sized subjects.

    摘要翻译： 本发明提供使用单个照相机和照射器的体内成像对象的表面映射，所述照相机将多个目标（例如斑点）投射在对象上。 通过限制照相机镜头或照明器光学器件或两者的景深，定义了一个空间平面，其中斑点最为突出。 该平面相对于被摄体的受控位移通过放置被摄体的机械台的移动来实现; 或者通过相机，透镜或照明器光学元件的调整来移动最佳对焦平面。 在最佳聚焦平面和被摄体的几个相对位置摄取图像，并且在给定已知位移的情况下，通过分析焦点来确定被摄体上各个点的高度。 可以从各个点位置构建网格或其他表面，以提供对象的表面图。 对于小鼠和类似大小的受试者，可以容易地获得0.5mm的精度。

    Surface measurement apparatus and method using depth of field
    8.
    发明申请
    Surface measurement apparatus and method using depth of field 有权
    表面测量装置和使用景深的方法

    公开(公告)号：US20080204697A1

    公开(公告)日：2008-08-28

    申请号：US12005471

    申请日：2007-12-27

    申请人： Peter Domenicali ,  Clifford Hoyt ,  Scott Determan ,  Peter Miller

    发明人： Peter Domenicali ,  Clifford Hoyt ,  Scott Determan ,  Peter Miller

    IPC分类号： G01C11/12

    CPC分类号： G01C11/12

    摘要： The invention provides for surface mapping of in-vivo imaging subjects using a single camera and a moveable stage on which a subject animal for in-vivo imaging is placed. Images are taken and the stage is moved by known amounts along the optical axis, and the heights of individual features on the subject are determined through analysis of focus, given the known stage displacement. Alternatively, height of sub-regions of the subject are determined through analysis of focus. A mesh or other surface can be constructed from individual features, to provide a surface map of the subject. Accuracy of 0.5 mm or better can be attained for mice and similarly sized subjects.

    摘要翻译： 本发明提供了使用单个照相机和放置用于体内成像的受试动物的可移动阶段的体内成像对象的表面映射。 拍摄图像并且沿着光轴移动已知量的阶段，并且考虑已知的阶段位移，通过对焦点的分析来确定对象上的个体特征的高度。 或者，通过对焦点的分析确定受试者的子区域的高度。 网格或其他表面可以从各个特征构造，以提供主体的表面图。 对于小鼠和类似大小的受试者，可以获得0.5mm或更好的精度。

    Surface measurement apparatus and method using depth of field
    10.
    发明授权
    Surface measurement apparatus and method using depth of field 有权
    表面测量装置和使用景深的方法

    公开(公告)号：US07782470B2

    公开(公告)日：2010-08-24

    申请号：US12005471

    申请日：2007-12-27

    申请人： Peter Domenicali ,  Clifford Hoyt ,  Scott Determan ,  Peter Miller

    发明人： Peter Domenicali ,  Clifford Hoyt ,  Scott Determan ,  Peter Miller

    IPC分类号： G01B11/14

    CPC分类号： G01C11/12

    摘要： The invention provides for surface mapping of in-vivo imaging subjects using a single camera and a moveable stage on which a subject animal for in-vivo imaging is placed. Images are taken and the stage is moved by known amounts along the optical axis, and the heights of individual features on the subject are determined through analysis of focus, given the known stage displacement. Alternatively, height of sub-regions of the subject are determined through analysis of focus. A mesh or other surface can be constructed from individual features, to provide a surface map of the subject. Accuracy of 0.5 mm or better can be attained for mice and similarly sized subjects.

    摘要翻译： 本发明提供了使用单个照相机和放置用于体内成像的受试动物的可移动阶段的体内成像对象的表面映射。 拍摄图像并且沿着光轴移动已知量的阶段，并且考虑已知的阶段位移，通过对焦点的分析来确定对象上的个体特征的高度。 或者，通过对焦点的分析确定受试者的子区域的高度。 网格或其他表面可以从各个特征构造，以提供主体的表面图。 对于小鼠和类似大小的受试者，可以获得0.5mm或更好的精度。