公开(公告)号：US20210261940A1

公开(公告)日：2021-08-26

申请号：US17316165

申请日：2021-05-10

Applicant: Codexis, Inc.

Inventor： Scott J. Novick ,  Xiang Yi ,  Nikki Dellas ,  Oscar Alvizo ,  Jovana Nazor ,  Da Duan ,  Vesna Mitchell ,  Jonathan Vroom ,  Santhosh Sivaramakrishnan ,  Nandhitha Subramanian ,  Jeffrey C. Moore ,  Mark Huffman ,  Agustina Rodriguez-Granillo ,  Deeptak Verma ,  Grant S. Murphy ,  Nicholas Marshall ,  Jay Russell ,  Keith A. Canada

IPC: C12N9/90 ,  C12N15/52 ,  C12N15/74 ,  C12N15/81

Abstract: The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

公开(公告)号：US11795445B2

公开(公告)日：2023-10-24

申请号：US17316165

申请日：2021-05-10

Applicant: Codexis, Inc.

Inventor： Scott J. Novick ,  Xiang Yi ,  Nikki Dellas ,  Oscar Alvizo ,  Jovana Nazor ,  Da Duan ,  Vesna Mitchell ,  Jonathan Vroom ,  Santhosh Sivaramakrishnan ,  Nandhitha Subramanian ,  Jeffrey C. Moore ,  Mark Huffman ,  Agustina Rodriguez-Granillo ,  Deeptak Verma ,  Grant S. Murphy ,  Nicholas Marshall ,  Jay Russell ,  Keith A. Canada

IPC: C12N15/52 ,  C12N9/90 ,  C12N15/74 ,  C12N15/81

CPC classification number: C12N9/90 ,  C12N15/52 ,  C12N15/74 ,  C12N15/815 ,  C12Y504/02007

Abstract: The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

公开(公告)号：US20240060064A1

公开(公告)日：2024-02-22

申请号：US18467259

申请日：2023-09-14

Applicant: Codexis, Inc.

Inventor： Scott J. Novick ,  Xiang Yi ,  Nikki Dellas ,  Oscar Alvizo ,  Jovana Nazor ,  Da Duan ,  Vesna Mitchell ,  Jonathan Vroom ,  Santhosh Sivaramakrishnan ,  Nandhitha Subramanian ,  Jeffrey C. Moore ,  Mark Huffman ,  Agustina Rodriguez-Granillo ,  Deeptak Verma ,  Grant S. Murphy ,  Nicholas Marshall ,  Jay Russell ,  Keith A. Canada

IPC: C12N9/90 ,  C12N15/52 ,  C12N15/74 ,  C12N15/81

CPC classification number: C12N9/90 ,  C12N15/52 ,  C12N15/74 ,  C12N15/815 ,  C12Y504/02007

Abstract: The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.