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公开(公告)号：US20080206184A1
公开(公告)日：2008-08-28
申请号：US12027641
申请日：2008-02-07
申请人： Colin V. Gegg , Olaf B. Kinstler
发明人： Colin V. Gegg , Olaf B. Kinstler
CPC分类号： C08L53/005 , A61K47/593 , A61K47/60 , C08L2666/02
摘要： The present invention broadly relates to the field of protein modification and more specifically, water soluble block polymers, their attachment to drugs, and methods of making and use thereof.
摘要翻译： 本发明广泛涉及蛋白质修饰领域，更具体地涉及水溶性嵌段聚合物，它们与药物的连接，以及制备和使用它们的方法。
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公开(公告)号：US08143380B2
公开(公告)日：2012-03-27
申请号：US11631461
申请日：2005-07-08
IPC分类号： C07K16/00
CPC分类号： A61K47/6811 , A61K47/60
摘要： The invention relates to compounds that exhibit improved bioefficacy in multidose administration. More specifically, the invention relates to polypeptides or peptides modified to include an antibody Fc region and one or more water soluble polymers.
摘要翻译： 本发明涉及在多剂量给药中表现出改善的生物功效的化合物。 更具体地，本发明涉及经修饰以包括抗体Fc区和一种或多种水溶性聚合物的多肽或肽。
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公开(公告)号：US08258262B2
公开(公告)日：2012-09-04
申请号：US12639398
申请日：2009-12-16
CPC分类号： A61K47/4823 , A61K38/00 , A61K47/60 , C07K14/535 , C07K14/56
摘要： Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.
摘要翻译： 本文提供了涉及将水溶性聚合物附着于蛋白质的方法和组合物。 提供了用于N-末端修饰蛋白质或其类似物的新方法，以及所得组合物，包括新型N-末端化学修饰的G-CSF组合物和相关制备方法。 还提供化学修饰的共有干扰素。
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公开(公告)号：US06956027B2
公开(公告)日：2005-10-18
申请号：US10264846
申请日：2002-10-04
申请人： Olaf B. Kinstler
发明人： Olaf B. Kinstler
IPC分类号： A61K38/00 , A61K47/48 , C07K14/535 , C07K14/56 , D05C1/02 , F16P3/16 , A61K38/22 , A61K38/16
CPC分类号： F16P3/16 , A61K38/00 , A61K47/60 , C07K14/535 , C07K14/56
摘要： Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel chemically modified G-CSF compositions and related methods of preparation.
摘要翻译： 本文提供了涉及将水溶性聚合物附着于蛋白质的方法和组合物。 提供了N-末端修饰蛋白质或其类似物的新方法，以及所得组合物，包括新型化学修饰的G-CSF组合物和相关的制备方法。
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公开(公告)号：US20100310510A1
公开(公告)日：2010-12-09
申请号：US12639398
申请日：2009-12-16
IPC分类号： A61K38/21 , C07K14/535 , A61K38/19 , C07K2/00 , A61P7/00
CPC分类号： A61K47/4823 , A61K38/00 , A61K47/60 , C07K14/535 , C07K14/56
摘要： Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.
摘要翻译： 本文提供了涉及将水溶性聚合物附着于蛋白质的方法和组合物。 提供了用于N-末端修饰蛋白质或其类似物的新方法，以及所得组合物，包括新型N-末端化学修饰的G-CSF组合物和相关制备方法。 还提供化学修饰的共有干扰素。
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公开(公告)号：US5985265A
公开(公告)日：1999-11-16
申请号：US879760
申请日：1997-06-20
IPC分类号： A61K38/21 , A61K31/00 , A61K38/00 , A61K38/19 , A61K47/30 , A61K47/48 , A61P1/16 , A61P3/06 , A61P7/00 , A61P7/06 , A61P9/10 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/04 , C07K20060101 , C07K1/06 , C07K1/107 , C07K1/113 , C07K1/13 , C07K14/52 , C07K14/53 , C07K14/535 , C07K14/555 , C07K14/56 , C07K17/08
CPC分类号： A61K47/4823 , A61K47/48176 , A61K47/48215 , C07K14/535 , C07K14/56 , A61K38/00
摘要： Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.
摘要翻译： 本文提供了涉及将水溶性聚合物附着于蛋白质的方法和组合物。 提供了N-末端修饰蛋白质或其类似物的新方法，以及所得组合物，包括新型化学修饰的G-CSF组合物和相关的制备方法。 还提供化学修饰的共有干扰素。
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公开(公告)号：US5824784A
公开(公告)日：1998-10-20
申请号：US321510
申请日：1994-10-12
IPC分类号： A61K38/21 , A61K31/00 , A61K38/00 , A61K38/19 , A61K47/30 , A61K47/48 , A61P1/16 , A61P3/06 , A61P7/00 , A61P7/06 , A61P9/10 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/04 , C07K20060101 , C07K1/06 , C07K1/107 , C07K1/113 , C07K1/13 , C07K14/52 , C07K14/53 , C07K14/535 , C07K14/555 , C07K14/56 , C07K17/08 , A61K38/18 , C07K1/00
CPC分类号： A61K47/4823 , A61K47/48176 , A61K47/48215 , C07K14/535 , C07K14/56 , A61K38/00
摘要： Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.
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公开(公告)号：US20130189219A1
公开(公告)日：2013-07-25
申请号：US13847290
申请日：2013-03-19
IPC分类号： A61K47/48
CPC分类号： A61K47/60 , A61K38/00 , C07K14/535 , C07K14/56
摘要： Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.
摘要翻译： 本文提供了涉及将水溶性聚合物附着于蛋白质的方法和组合物。 提供了用于N-末端修饰蛋白质或其类似物的新方法，以及所得组合物，包括新型N-末端化学修饰的G-CSF组合物和相关制备方法。 还提供化学修饰的共有干扰素。
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公开(公告)号：US20120296072A1
公开(公告)日：2012-11-22
申请号：US13565447
申请日：2012-08-02
IPC分类号： C07K1/113
CPC分类号： A61K47/60 , A61K38/00 , C07K14/535 , C07K14/56
摘要： Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.
摘要翻译： 本文提供了涉及将水溶性聚合物附着于蛋白质的方法和组合物。 提供了用于N-末端修饰蛋白质或其类似物的新方法，以及所得组合物，包括新型N-末端化学修饰的G-CSF组合物和相关制备方法。 还提供化学修饰的共有干扰素。
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10.发明授权Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation 失效刺激巨核细胞生长和分化的单聚乙二醇化蛋白质
公开(公告)号：US5795569A
公开(公告)日：1998-08-18
申请号：US321488
申请日：1994-10-12
申请人： Timothy D. Bartley , Jakob M. Bogenberger , Robert A. Bosselman , Pamela Hunt , Olaf B. Kinstler , Babru B. Samal
发明人： Timothy D. Bartley , Jakob M. Bogenberger , Robert A. Bosselman , Pamela Hunt , Olaf B. Kinstler , Babru B. Samal
IPC分类号： A61K38/00 , A61K38/16 , C07H21/04 , C07K14/475 , C07K14/52 , C07K17/08 , C12N15/09 , C07K1/113 , A61K38/19
CPC分类号： C07K14/524 , C07K17/08 , A61K38/00 , Y10S930/14
摘要： Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands or thrombopoietin, that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.
摘要翻译： 公开了被称为巨核细胞生长和发育因子（MGDFs;也通常称为Mpl配体或血小板生成素）的新型蛋白质，其具有刺激巨核细胞生长并增加巨核细胞分化或成熟的生物活性，最终导致 还公开了包含与水溶性聚合物如聚乙二醇相连的MGDF分子的MGDF衍生物及其制备方法，还公开了从天然来源获得均匀形式的MGDF的方法，并通过 来自哺乳动物，包括人类的重组基因工程技术。
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