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公开(公告)号：US10266408B2
公开(公告)日：2019-04-23
申请号：US14597832
申请日：2015-01-15
IPC分类号： A61K33/00 , A61L29/14 , A61L31/06 , A61L31/16 , A61L31/14 , A61L29/16 , A61L29/06 , C01B21/26 , A61L27/54 , C01B21/24
摘要： A metal-organic compound containing polymer matrix includes a polymer and a three-dimensional metal-organic framework includes a polydentate organic linker. The metal-organic compound containing polymer matrix is configured to continuously produce nitric oxide when exposed to a physiological fluid including a nitric oxide-releasing compound via a catalytic reaction catalyzed by the three-dimensional metal-organic framework.
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2.发明授权公开(公告)号：US09493352B2
公开(公告)日：2016-11-15
申请号：US14192691
申请日：2014-02-27
IPC分类号： C01B21/26 , A61K33/00 , A61L27/54 , A61L29/16 , A61L31/16 , C01B21/24 , A61L29/06 , A61L31/06 , A61L29/14 , A61L31/14
CPC分类号： C01B21/265 , A61K33/00 , A61L27/54 , A61L29/06 , A61L29/146 , A61L29/16 , A61L31/06 , A61L31/146 , A61L31/16 , A61L2300/114 , A61L2300/608 , C01B21/24
摘要： The present disclosure is directed to a method of producing nitric oxide comprising (i) providing a composition comprising a metal-organic framework, and (ii) exposing the composition to a nitric oxide-releasing compound. The disclosure also is directed to compositions, coatings, and medical devices comprising a metal-organic framework.
摘要翻译： 本公开涉及一种生产一氧化氮的方法，其包括（i）提供包含金属 - 有机骨架的组合物，和（ii）将所述组合物暴露于释放一氧化氮的化合物。 本公开还涉及包含金属 - 有机骨架的组合物，涂层和医疗装置。
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3.发明申请公开(公告)号：US20150118268A1
公开(公告)日：2015-04-30
申请号：US14597832
申请日：2015-01-15
CPC分类号： C01B21/265 , A61K33/00 , A61L27/54 , A61L29/06 , A61L29/146 , A61L29/16 , A61L31/06 , A61L31/146 , A61L31/16 , A61L2300/114 , A61L2300/608 , C01B21/24
摘要： A metal-organic compound containing polymer matrix includes a polymer and a three-dimensional metal-organic framework includes a polydentate organic linker. The metal-organic compound containing polymer matrix is configured to continuously produce nitric oxide when exposed to a physiological fluid including a nitric oxide-releasing compound via a catalytic reaction catalyzed by the three-dimensional metal-organic framework.
摘要翻译： 含有金属有机化合物的聚合物基质包括聚合物和三维金属 - 有机骨架包括多齿有机连接体。 含有金属有机化合物的聚合物基质被配置为当通过由三维金属 - 有机骨架催化的催化反应暴露于包含一氧化氮释放化合物的生理液体时，连续产生一氧化氮。
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公开(公告)号：US20140178504A1
公开(公告)日：2014-06-26
申请号：US14192691
申请日：2014-02-27
CPC分类号： C01B21/265 , A61K33/00 , A61L27/54 , A61L29/06 , A61L29/146 , A61L29/16 , A61L31/06 , A61L31/146 , A61L31/16 , A61L2300/114 , A61L2300/608 , C01B21/24
摘要： The present disclosure is directed to a method of producing nitric oxide comprising (i) providing a composition comprising a metal-organic framework, and (ii) exposing the composition to a nitric oxide-releasing compound. The disclosure also is directed to compositions, coatings, and medical devices comprising a metal-organic framework.
摘要翻译： 本公开涉及一种生产一氧化氮的方法，其包括（i）提供包含金属 - 有机骨架的组合物，和（ii）将所述组合物暴露于释放一氧化氮的化合物。 本公开还涉及包含金属 - 有机骨架的组合物，涂层和医疗装置。
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