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公开(公告)号：US20210169082A1
公开(公告)日：2021-06-10
申请号：US16630264
申请日：2018-07-11
摘要： A substrate having an antibacterial surface includes a chitosan matrix and water-stable metal-organic frameworks dispersed throughout the chitosan matrix. The water-stable metal-organic frame-works are present in an amount of 5% wt/wt to 20% wt/wt based on total solids of the substrate
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公开(公告)号：US10266408B2
公开(公告)日：2019-04-23
申请号：US14597832
申请日：2015-01-15
IPC分类号： A61K33/00 , A61L29/14 , A61L31/06 , A61L31/16 , A61L31/14 , A61L29/16 , A61L29/06 , C01B21/26 , A61L27/54 , C01B21/24
摘要： A metal-organic compound containing polymer matrix includes a polymer and a three-dimensional metal-organic framework includes a polydentate organic linker. The metal-organic compound containing polymer matrix is configured to continuously produce nitric oxide when exposed to a physiological fluid including a nitric oxide-releasing compound via a catalytic reaction catalyzed by the three-dimensional metal-organic framework.
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公开(公告)号：US20210114011A1
公开(公告)日：2021-04-22
申请号：US16500243
申请日：2018-04-11
发明人： Melissa M. Reynolds , Heather Rubin
摘要： In some embodiments, a metal-organic framework material includes tricarboxylate metal-organic frameworks. The tricarboxylate metal-organic frameworks include unmodified tricarboxylate ligands and modified tricarboxylate ligands. The modified tricarboxylate ligands are unmodified tricarboxylate ligand modified with aliphatic carbon chains. Methods of forming metal-organic framework materials and textiles containing modified metal-organic framework materials are also provided.
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公开(公告)号：US20160089444A1
公开(公告)日：2016-03-31
申请号：US14710362
申请日：2015-05-12
CPC分类号： A61K33/00 , A61K47/593 , A61K47/61
摘要： A polymeric composition capable of releasing nitric oxide and modulating biological responses comprises a biocompatible polymer and S-nitrosated thiol bonded to the biocompatible polymer. The polymeric composition can have a thiol conversion of at least 40%. The polymeric composition can also have a nitric oxide recovery of at least 40% when under thermal decomposition conditions.
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5.发明申请公开(公告)号：US20150118268A1
公开(公告)日：2015-04-30
申请号：US14597832
申请日：2015-01-15
CPC分类号： C01B21/265 , A61K33/00 , A61L27/54 , A61L29/06 , A61L29/146 , A61L29/16 , A61L31/06 , A61L31/146 , A61L31/16 , A61L2300/114 , A61L2300/608 , C01B21/24
摘要： A metal-organic compound containing polymer matrix includes a polymer and a three-dimensional metal-organic framework includes a polydentate organic linker. The metal-organic compound containing polymer matrix is configured to continuously produce nitric oxide when exposed to a physiological fluid including a nitric oxide-releasing compound via a catalytic reaction catalyzed by the three-dimensional metal-organic framework.
摘要翻译： 含有金属有机化合物的聚合物基质包括聚合物和三维金属 - 有机骨架包括多齿有机连接体。 含有金属有机化合物的聚合物基质被配置为当通过由三维金属 - 有机骨架催化的催化反应暴露于包含一氧化氮释放化合物的生理液体时，连续产生一氧化氮。
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公开(公告)号：US20140178504A1
公开(公告)日：2014-06-26
申请号：US14192691
申请日：2014-02-27
CPC分类号： C01B21/265 , A61K33/00 , A61L27/54 , A61L29/06 , A61L29/146 , A61L29/16 , A61L31/06 , A61L31/146 , A61L31/16 , A61L2300/114 , A61L2300/608 , C01B21/24
摘要： The present disclosure is directed to a method of producing nitric oxide comprising (i) providing a composition comprising a metal-organic framework, and (ii) exposing the composition to a nitric oxide-releasing compound. The disclosure also is directed to compositions, coatings, and medical devices comprising a metal-organic framework.
摘要翻译： 本公开涉及一种生产一氧化氮的方法，其包括（i）提供包含金属 - 有机骨架的组合物，和（ii）将所述组合物暴露于释放一氧化氮的化合物。 本公开还涉及包含金属 - 有机骨架的组合物，涂层和医疗装置。
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7.发明授权公开(公告)号：US09493352B2
公开(公告)日：2016-11-15
申请号：US14192691
申请日：2014-02-27
IPC分类号： C01B21/26 , A61K33/00 , A61L27/54 , A61L29/16 , A61L31/16 , C01B21/24 , A61L29/06 , A61L31/06 , A61L29/14 , A61L31/14
CPC分类号： C01B21/265 , A61K33/00 , A61L27/54 , A61L29/06 , A61L29/146 , A61L29/16 , A61L31/06 , A61L31/146 , A61L31/16 , A61L2300/114 , A61L2300/608 , C01B21/24
摘要： The present disclosure is directed to a method of producing nitric oxide comprising (i) providing a composition comprising a metal-organic framework, and (ii) exposing the composition to a nitric oxide-releasing compound. The disclosure also is directed to compositions, coatings, and medical devices comprising a metal-organic framework.
摘要翻译： 本公开涉及一种生产一氧化氮的方法，其包括（i）提供包含金属 - 有机骨架的组合物，和（ii）将所述组合物暴露于释放一氧化氮的化合物。 本公开还涉及包含金属 - 有机骨架的组合物，涂层和医疗装置。
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