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公开(公告)号：US20160222203A1
公开(公告)日：2016-08-04
申请号：US14917795
申请日：2014-09-10
发明人： Susan P. James , Travis S. Bailey , Ketul C. Popat , David A. Prawel , Jackson T. Lewis , Richard L. Koch
CPC分类号： C08L43/04 , A61F2/16 , A61F2002/1681 , A61L27/48 , C08G77/388 , G02B1/043 , G02C7/049
摘要： Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.
摘要翻译： 本文提供了包含聚合物主体的聚合物材料; 和包含糖胺聚糖的客体分子; 其中所述客体分子设置在所述聚合物主体内，并且其中所述客体分子共价键合至至少一个其它客体分子。 在一些实施方案中，聚合物主体包含硅氧烷基聚合物。 在其它实施方案中，糖胺聚糖选自透明质酸及其衍生物。
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公开(公告)号：US10167387B2
公开(公告)日：2019-01-01
申请号：US14917795
申请日：2014-09-10
发明人： Susan P. James , Travis S. Bailey , Ketul C. Popat , David A. Prawel , Jackson T. Lewis , Richard L. Koch
摘要： Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.
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3.发明申请Glycosaminoglycan and Synthetic Polymer Material for Blood-Contacting Applications 审中-公开用于血液接触应用的糖胺聚糖和合成聚合物材料公开(公告)号：US20150196688A1
公开(公告)日：2015-07-16
申请号：US14381332
申请日：2013-03-11
发明人： Susan P. James , Harold Dean, IV , Lakshmi Prasad Dasi , Marcio H. Forleo , Ketul C. Popat , Nicole R. Lewis , David Alois Prawel
CPC分类号： A61L27/48 , A61F2/24 , A61L17/10 , A61L27/16 , A61L27/18 , A61L27/20 , A61L27/50 , A61L27/54 , A61L29/126 , A61L29/14 , A61L31/129 , A61L31/14 , A61L2300/236 , A61L2300/42 , A61L2300/62 , A61L2430/20 , C08L5/08
摘要： Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), and polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.
摘要翻译： 本文提供的复合材料包括：选自低密度聚乙烯（LDPE），线性低密度聚乙烯（LLDPE），聚对苯二甲酸乙二醇酯（PET），聚四氟乙烯（PTFE）和聚丙烯（PP） ，聚氨酯，聚己内酯（PCL），聚二甲基硅氧烷（PDMS），聚甲基丙烯酸甲酯（PMMA）和聚甲醛（POM）; 和包含透明质酸的客体分子; 其中所述客体分子设置在所述聚合物主体内，并且其中所述客体分子共价键合至至少一个其它客体分子。 还提供了用于形成复合材料的方法和由复合材料制成的收缩装置，例如心脏瓣膜和血管移植物。
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公开(公告)号：US10071186B2
公开(公告)日：2018-09-11
申请号：US14381332
申请日：2013-03-11
发明人： Susan P. James , Harold Dean, IV , Lakshmi Prasad Dasi , Marcio H. Forleo , Ketul C. Popat , Nicole R. Lewis , David Alois Prawel
IPC分类号： A61L27/48 , A61F2/24 , A61L27/18 , A61L27/20 , A61L27/54 , A61L27/16 , A61L27/50 , A61L29/12 , A61L29/14 , A61L31/12 , A61L31/14 , A61L17/10
摘要： Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), and polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.
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