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1.发明授权Process for splitting off .DELTA..sup.4 -unsaturated uronic acid from glycosaminoglycans 失效从糖胺聚糖中分离出DELTA 4不饱和糖醛酸的方法
公开(公告)号：US5451668A
公开(公告)日：1995-09-19
申请号：US466161
申请日：1990-01-17
CPC分类号： C08B37/0078
摘要： Process for splitting off .DELTA..sup.4 -unsaturated uronic acid from glycosaminoglycan, in which the glycosaminoglycan is treated with an iodine solution or with a bleaching reagent, or with a combination thereof.
摘要翻译： 从糖胺聚糖中分离DELTA 4-不饱和糖醛酸的方法，其中用碘溶液或漂白试剂处理糖胺聚糖或其组合。
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公开(公告)号：US5705489A
公开(公告)日：1998-01-06
申请号：US690449
申请日：1996-08-05
IPC分类号： C07H7/033 , A61K20060101 , A61K31/70 , A61K31/7012 , A61K47/48 , A61P7/02 , A61P43/00 , C07H20060101 , C07H3/06 , C07H7/04 , C07H11/00 , C07H13/00 , C07H15/04 , C07H15/08 , C07H15/18 , C07H15/22 , C07H15/26 , C07K9/00 , C08B37/00 , C08B37/10 , C07H15/00
摘要： The invention relates to a tuneable bisconjugate comprising two saccharides and a spacer, each saccharide being the same or different and comprising two to six monosaccharide units, at least one unit being uronic acid, characterized in that at least one of the saccharides per se has anti-thrombotic activity, and that the spacer connects at least one saccharide to the other through its non-reducing end, the chain length of the spacer being 20-120 atoms.
摘要翻译： 本发明涉及包含两种糖类和间隔物的可调式双缀合物，每种糖相同或不同，并且包含两至六个单糖单元，至少一个单元是糖醛酸，其特征在于，至少一种糖本身具有抗 并且间隔物通过其非还原性末端将至少一个糖连接到另一个，间隔物的链长为20-120个原子。
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3.发明授权Phosphorylating agent and process for the phosphorylation of organic hydroxyl compounds 失效磷酸化剂和有机羟基化合物的磷酸化方法
公开(公告)号：US4503233A
公开(公告)日：1985-03-05
申请号：US376510
申请日：1982-05-10
IPC分类号： C07F9/6518 , C07H21/00 , C07F9/65
CPC分类号： C07H21/00 , C07F9/65188
摘要： The invention relates to new phosphorylating agents, a process for producing said compounds and their use in a process for the phosphorylation of organic hydroxyl compounds to obtain intermediate products useful for the production of polynucleotides. The phosphorylation is achieved without side reactions at the purine- or pyrimidine bases.
摘要翻译： 本发明涉及新的磷酸化剂，所述化合物的制备方法及其在有机羟基化合物的磷酸化方法中的用途，以获得可用于生产多核苷酸的中间产物。 在嘌呤或嘧啶碱基处没有副反应实现磷酸化。
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4.发明授权Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type 失效硫酸盐型糖胺聚糖衍生物肝素和硫酸乙酰肝素型
公开(公告)号：US5543403A
公开(公告)日：1996-08-06
申请号：US325841
申请日：1994-10-19
IPC分类号： C07H11/00 , C07H15/04 , A61K31/715 , A61K31/725 , C07H5/10 , C08B37/10
摘要： The invention relates to sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type, of which N-sulfate, N-acetate, and hydroxy groups, are replaced by alkoxy, aryloxy, aralkoxy, or O-sulfate groups. The compounds have antithrombotic and smooth muscle cell proliferation inhibiting activities.
摘要翻译： 本发明涉及肝素和硫酸乙酰肝素型的硫酸化糖胺聚糖衍生物，其中N-硫酸盐，N-乙酸酯和羟基被烷氧基，芳氧基，芳烷氧基或O-硫酸酯基取代。 该化合物具有抗血栓形成和平滑肌细胞增殖抑制活性。
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5.发明授权
公开(公告)号：US5514659A
公开(公告)日：1996-05-07
申请号：US230921
申请日：1994-04-21
IPC分类号： C07H3/08 , A61K31/70 , A61K31/702 , A61K31/7028 , A61K31/726 , A61K31/737 , A61P7/02 , C07H3/04 , C07H3/06 , C07H3/10 , C07H11/00 , C07H13/04 , C07H13/08 , C07H15/04 , A61K31/725
摘要： The invention relates to 3-deoxy oligosaccharides of formula I: ##STR1## in which X represents an --OSO.sub.3.sup.- radical, a radical of formula R--O, a radical of formula: ##STR2## or a radical of formula: ##STR3## Y represents a radical of formula: ##STR4## R represents an alkyl radical, R.sub.1, R.sub.3, R.sub.5, R.sub.7, R.sub.8, R.sub.10, R.sub.12 and R.sub.13 represent a hydroxyl radical, an alkoxy radical or an --OSO.sub.3.sup.- radical,R.sub.2, R.sub.4, R.sub.6, R.sub.9 and R.sub.11 represent a hydrogen atom, a hydroxyl radical, an alkoxy radical or an --OSO.sub.3.sup.- radical, with the proviso that at least R.sub.2 or R.sub.4 or R.sub.6 or R.sub.9 or R.sub.11 represents a hydrogen atom,and their pharmaceutically acceptable salts with a base.
摘要翻译： 本发明涉及式I的3-脱氧低聚糖：其中X代表-OSO 3 - 基，式RO基团，式：基团或下式基团： > Y表示式的基团：R 1表示烷基，R 1，R 3，R 5，R 7，R 8，R 10，R 12和R 13表示羟基，烷氧基或-OSO 3 - 基，R 2，R 4 ，R 6，R 9和R 11表示氢原子，羟基，烷氧基或-OSO 3 - 基，条件是至少R 2或R 4或R 6或R 9或R 11表示氢原子，及其药学上可接受的盐 与一个基地。
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