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    Ureteral endoluminal abrasion device
    1.
    发明授权
    Ureteral endoluminal abrasion device 有权
    输尿管内脏磨损装置

    公开(公告)号：US09539127B2

    公开(公告)日：2017-01-10

    申请号：US14136975

    申请日：2013-12-20

    Applicant: Cook Medical Technologies LLC

    Inventor： Steven L. Pendleton ,  Steven J. Charlebois

    IPC: A61M27/00 ,  A61F2/95

    CPC classification number: A61F2/95 ,  A61F2/04 ,  A61F2002/048 ,  A61F2210/0071 ,  A61F2250/0067 ,  A61M27/008 ,  A61M2205/0205

    Abstract: An endoluminal medical device includes a cannula, the cannula having a proximal end and a distal end; an abrasion member having a series of struts interconnected by a series of bent segments forming a plurality of prongs attached to the cannula, the abrasion member having a first section and a second section; where the prongs of the first section of the abrasion member extend radially outward from the cannula.

    Abstract translation: 腔内医疗装置包括套管，套管具有近端和远端; 磨损构件，其具有通过一系列弯曲部分相互连接的支柱，所述一系列弯曲部分形成附接到所述套管的多个尖头，所述磨损构件具有第一部分和第二部分; 其中磨损构件的第一部分的尖头从套管径向向外延伸。

    COMPOSITIONS, DEVICES AND METHODS OF TREATING INFECTIONS
    2.
    发明申请
    COMPOSITIONS, DEVICES AND METHODS OF TREATING INFECTIONS 审中-公开
    组合物，设备和治疗感染的方法

    公开(公告)号：US20150182527A1

    公开(公告)日：2015-07-02

    申请号：US14572057

    申请日：2014-12-16

    Applicant: COOK MEDICAL TECHNOLOGIES LLC

    Inventor： Steven L. Pendleton ,  Will C. McRoy, JR.

    IPC: A61K31/506 ,  A61L29/14 ,  A61L29/16 ,  A61K31/14 ,  A61K31/4196

    CPC classification number: A61K31/506 ,  A61K31/14 ,  A61K31/4196 ,  A61L27/14 ,  A61L27/54 ,  A61L29/04 ,  A61L29/16 ,  A61L31/04 ,  A61L31/16 ,  A61L2300/208 ,  A61L2300/404 ,  A61M25/0017 ,  A61M27/008 ,  A61M2025/0056 ,  A61K2300/00

    Abstract: One aspect provides a composition including a quaternary ammonium salt and an azole. The azole and the quaternary ammonium salt can be present in proportions providing a synergistic effect against a fungal organism. In one embodiment, the composition also includes a pharmaceutically acceptable carrier. Another aspect provides implantable medical devices containing a composition including a quaternary ammonium salt and an azole. In certain embodiments, the combination is present in an elutable form. Another aspect provides methods of treating a human or veterinary patient for an infection including administrating a composition including a quaternary ammonium salt and an azole.

    Abstract translation: 一方面提供了包含季铵盐和唑的组合物。 唑和季铵盐可以按照提供对真菌生物体的协同作用的比例存在。 在一个实施方案中，组合物还包括药学上可接受的载体。 另一方面提供了含有包含季铵盐和唑的组合物的可植入医疗装置。 在某些实施方案中，组合以可洗涤形式存在。 另一方面提供了治疗人或兽医患者感染的方法，包括施用包含季铵盐和唑的组合物。

    Bioactive Compositions, Bioactive Eluting Devices and Methods of Use Thereof
    5.
    发明申请
    Bioactive Compositions, Bioactive Eluting Devices and Methods of Use Thereof 审中-公开
    生物活性组合物，生物活性洗脱装置及其使用方法

    公开(公告)号：US20140172118A1

    公开(公告)日：2014-06-19

    申请号：US14086575

    申请日：2013-11-21

    Applicant: Cook Medical Technologies LLC

    Inventor： Steven L. Pendleton ,  Jeffrey D. Williams

    IPC: A61F2/04 ,  A61K31/517

    CPC classification number: A61F2/04 ,  A61K31/517 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/802

    Abstract: One aspect provides a composition including triacetin, dimethyl sulfoxide and a bioactive. In one embodiment, the composition also includes a pharmaceutically acceptable carrier. Another aspect provides implantable medical devices including an elutable bioactive, triacetin and dimethyl sulfoxide. In certain embodiments, the combination of triacetin and dimethyl sulfoxide acts as a permeation enhancing agent by allowing the delivery of an increased amount of the bioactive to the tissue of a human or veterinary patient. Another aspect provides methods of delivering the bioactive to the tissue of the patient, including the step of administrating the composition to the patient or implanting the device within the patient.

    Abstract translation: 一方面提供包含三醋精，二甲基亚砜和生物活性的组合物。 在一个实施方案中，组合物还包括药学上可接受的载体。 另一方面提供可植入医疗装置，其包括可洗涤的生物活性，三醋精和二甲基亚砜。 在某些实施方案中，通过允许向人或兽医患者的组织递送增加量的生物活性，三醋精和二甲基亚砜的组合用作渗透促进剂。 另一方面提供将生物活性递送到患者组织的方法，包括将组合物施用于患者或将该装置植入患者体内的步骤。

    Low maintenance endotracheal tube device and method for preventing ventilator associated pneumonia and tracheal ischemia
    6.
    发明授权
    Low maintenance endotracheal tube device and method for preventing ventilator associated pneumonia and tracheal ischemia 有权

    公开(公告)号：US10369312B2

    公开(公告)日：2019-08-06

    申请号：US15019719

    申请日：2016-02-09

    Applicant: Cook Medical Technologies LLC

    Inventor： Steven L. Pendleton ,  Jeffrey D. Williams ,  Gary L. Neff

    IPC: A61M16/04

    Abstract: A method of sealing a trachea is provided that includes inserting a tracheal tube having an inflatable cuff made of a compliant material into a trachea. The method includes inflating the inflatable cuff with a fluid to a first pressure that exceeds a second pressure necessary to create a seal between the inflatable cuff and the tracheal wall. The method includes deflating the inflatable cuff by releasing a first pressure to allow the fluid to flow out of the inflatable cuff without applying vacuum pressure to the fluid while evaluating a rate of change of pressure of the fluid in the inflatable cuff. The method includes identifying a variance in the rate of change of pressure corresponding to a third pressure at which the inflatable cuff separates from the tracheal wall, determining the second pressure by analyzing the third pressure, and reinflating the inflatable cuff to the second pressure.

    LOW MAINTENANCE ENDOTRACHEAL TUBE DEVICE AND METHOD FOR PREVENTING VENTILATOR ASSOCIATED PNEUMONIA AND TRACHEAL ISCHEMIA
    8.
    发明申请
    LOW MAINTENANCE ENDOTRACHEAL TUBE DEVICE AND METHOD FOR PREVENTING VENTILATOR ASSOCIATED PNEUMONIA AND TRACHEAL ISCHEMIA 审中-公开
    低维护性内管装置及预防通气管相关PNEUMONIA和TRACHEAL ISCHEMIA的方法

    公开(公告)号：US20160228662A1

    公开(公告)日：2016-08-11

    申请号：US15019719

    申请日：2016-02-09

    Applicant: Cook Medical Technologies LLC

    Inventor： Steven L. Pendleton ,  Jeffrey D. Williams ,  Gary L. Neff

    IPC: A61M16/04

    CPC classification number: A61M16/044 ,  A61M16/0438 ,  A61M16/0443 ,  A61M16/0456 ,  A61M16/0465 ,  A61M16/0481 ,  A61M2205/0222 ,  A61M2205/3331

    Abstract: A method of sealing a trachea is provided that includes inserting a tracheal tube having an inflatable cuff made of a compliant material into a trachea. The method includes inflating the inflatable cuff with a fluid to a first pressure that exceeds a second pressure necessary to create a seal between the inflatable cuff and the tracheal wall. The method includes deflating the inflatable cuff by releasing a first pressure to allow the fluid to flow out of the inflatable cuff without applying vacuum pressure to the fluid while evaluating a rate of change of pressure of the fluid in the inflatable cuff. The method includes identifying a variance in the rate of change of pressure corresponding to a third pressure at which the inflatable cuff separates from the tracheal wall, determining the second pressure by analyzing the third pressure, and reinflating the inflatable cuff to the second pressure.

    Abstract translation: 提供一种密封气管的方法，其包括将具有由顺应性材料制成的可膨胀箍的气管管插入气管。 该方法包括将可膨胀的袖带用流体充气到超过在可充气袖带和气管壁之间形成密封所需的第二压力的第一压力。 该方法包括通过释放第一压力来释放可充气袖带，以允许流体从可充气袖带流出，而不对流体施加真空压力，同时评估可充气袖带中的流体的压力变化率。 该方法包括识别对应于可膨胀袖带与气管壁分离的第三压力的压力变化率的变化，通过分析第三压力确定第二压力，以及将可充气袖带重新充气至第二压力。

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