公开(公告)号：US07589065B2

公开(公告)日：2009-09-15

申请号：US10487750

申请日：2002-08-20

申请人： Cordelia Schiene-Fischer ,  Gunter Fischer ,  Judith Maria Habazettl ,  Gerhard Küllertz

发明人： Cordelia Schiene-Fischer ,  Gunter Fischer ,  Judith Maria Habazettl ,  Gerhard Küllertz

IPC分类号： A61K31/16 ,  A61K38/05 ,  C07C233/31 ,  C07K5/06

CPC分类号： C07K7/56 ,  A61K38/00

摘要： The present invention is based on the finding that the cis/trans isomerisation of secondary amide peptide bonds in oligo- and polypeptides can be catalytically promoted. This catalysis is effected by enzymes which are hereinafter called “secondary amide peptide bond cis/trans isomerases (APIases). It can be assumed that the APIase activity plays a central role in a number of pathophysiological processes. Thus, the invention relates to pharmaceutical compositions comprising substances which inhibit APIase activity.

摘要翻译： 本发明基于以下发现：可以催化促进寡肽和多肽中的仲酰胺肽键的顺/反异构化。 这种催化通过下文称为“仲酰胺肽键顺式/反式异构酶（APIase）”的酶来实现，可以认为APIase活性在多种病理生理过程中起关键作用，因此本发明涉及药物组合物 包括抑制APIase活性的物质。

公开(公告)号：US20100160175A1

公开(公告)日：2010-06-24

申请号：US12583818

申请日：2009-08-26

申请人： Cordelia Schiene-Fischer ,  Gunter Fischer ,  Judith Maria Habazettl ,  Gerhard Küllertz

发明人： Cordelia Schiene-Fischer ,  Gunter Fischer ,  Judith Maria Habazettl ,  Gerhard Küllertz

IPC分类号： C12Q1/533 ,  C40B30/04

CPC分类号： C07K7/56 ,  A61K38/00

摘要： The present invention is based on the finding that the cis/trans isomerisation of secondary amide peptide bonds in oligo- and polypeptides can be catalytically promoted. This catalysis is effected by enzymes which are hereinafter called “secondary amide peptide bond cis/trans isomerases (APIases). It can be assumed that the APIase activity plays a central role in a number of pathophysiological processes. Thus, the invention relates to pharmaceutical compositions comprising substances which inhibit APIase activity.

摘要翻译： 本发明基于以下发现：可以催化促进寡肽和多肽中的仲酰胺肽键的顺/反异构化。 这种催化由下文称为“仲酰胺肽键顺/反异构酶（APIase）”的酶实现。 可以假设APIase活性在许多病理生理过程中起核心作用。 因此，本发明涉及包含抑制APIase活性的物质的药物组合物。

公开(公告)号：US20100041747A1

公开(公告)日：2010-02-18

申请号：US12377788

申请日：2007-08-14

申请人： Gunter Fischer ,  Cordelia Schiene-Fischer ,  Sebastian Daum ,  Gerhard Küllertz ,  Manfred Braun

发明人： Gunter Fischer ,  Cordelia Schiene-Fischer ,  Sebastian Daum ,  Gerhard Küllertz ,  Manfred Braun

IPC分类号： A61K31/12 ,  A61K31/136 ,  A61K31/365 ,  A61P29/00 ,  A61P37/00 ,  A61P31/04 ,  A61P31/10 ,  A61P35/00 ,  A61P31/12 ,  A61P33/00 ,  A61P33/02 ,  A61P35/02

CPC分类号： A61K31/12 ,  A61K31/136 ,  A61K31/343 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/471 ,  Y02A50/475 ,  Y02A50/481 ,  Y02A50/483

摘要： The present invention relates to the use of certain spiro, ketone and carboxylic acid compounds for the inhibition of the peptidyl-prolyl cis/trans isomerase activity of cyclophilins and the use of these compounds for the production of a cosmetic or pharmaceutical composition for the promotion of hair growth or for the treatment or prevention of inflammatory autoimmune diseases, of diseases caused by fungi, of bacterial infections, of viral infections, of diseases caused by parasites, protozoa or worms, of cancer, of diseases of cells, of fibrosing diseases, and of non-neoplastic changes and diseases which are attributable to prions and changes in the structure and function of cellular proteins and cells.

摘要翻译： 本发明涉及某些螺，酮和羧酸化合物用于抑制亲环蛋白的肽基 - 脯氨酰顺/反异构酶活性的用途，以及这些化合物用于生产化妆品或药物组合物以促进 毛发生长或用于治疗或预防炎性自身免疫疾病，由真菌引起的疾病，细菌感染，病毒感染，由寄生虫，原虫或蠕虫引起的疾病，癌症，细胞疾病，纤维化疾病和 的非肿瘤性变化和疾病，其归因于细胞蛋白和细胞的结构和功能的朊病毒和变化。

公开(公告)号：US20100311661A1

公开(公告)日：2010-12-09

申请号：US12675034

申请日：2007-08-24

申请人： Gerhard Küllertz ,  Gunter Fischer ,  Steffi Rau ,  Britta Erika Husse

发明人： Gerhard Küllertz ,  Gunter Fischer ,  Steffi Rau ,  Britta Erika Husse

IPC分类号： A61K38/05 ,  A61K31/45 ,  A61P9/10 ,  A61P13/12 ,  A61P1/16 ,  A61P1/00 ,  A61P9/00 ,  A61P11/00 ,  A61P1/18 ,  A61P19/02 ,  A61P29/00 ,  A01N1/02

CPC分类号： A61K31/45

摘要： The present invention relates to the use of certain derivatives of cycloheximide or the pharmaceutically acceptable salts thereof for the manufacture of a medicament for the treatment or prevention of ischaemias, of cardiopathies, of endothelial disorders, of traumata, of necroses, of pulmonary disorders, of vascular disorders, of forms of shock, of blood flow impairments or of stroke; or for the manufacture of a medicament for the treatment or prevention of diseases caused by ischaemia; or for the manufacture of a composition for the preservation and/or storage of transplants, especially of organs.

摘要翻译： 本发明涉及放线菌酮的某些衍生物或其药学上可接受的盐在制备用于治疗或预防心律失常，心内膜疾病，创伤，坏死，肺部疾病， 血管疾病，休克形式，血液流动障碍或中风; 或用于制造用于治疗或预防由缺血引起的疾病的药物; 或用于制造用于保存和/或储存移植物，特别是器官的组合物。