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公开(公告)号：US5807826A
公开(公告)日：1998-09-15
申请号：US835268
申请日：1997-04-08
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K39/395 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/07 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/85 , C12P21/02 , C12Q1/00 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , A61K38/04 , A61K38/16
CPC分类号： C12N15/8509 , A01K67/0339 , C07K14/005 , C07K14/4703 , C07K14/705 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
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公开(公告)号：US5935865A
公开(公告)日：1999-08-10
申请号：US60692
申请日：1998-04-15
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K39/395 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/07 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/85 , C12P21/02 , C12Q1/00 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
CPC分类号： C12N15/8509 , A01K67/0339 , C07K14/005 , C07K14/4703 , C07K14/705 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
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公开(公告)号：US6013781A
公开(公告)日：2000-01-11
申请号：US833391
申请日：1997-04-08
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K39/395 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/07 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/85 , C12P21/02 , C12Q1/00 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C12N15/11
CPC分类号： C12N15/8509 , A01K67/0339 , C07K14/005 , C07K14/4703 , C07K14/705 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
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公开(公告)号：US5639856A
公开(公告)日：1997-06-17
申请号：US121713
申请日：1993-09-13
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K39/395 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/07 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/85 , C12P21/02 , C12Q1/00 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , A61K38/04 , A61K38/16 , C07K14/005
CPC分类号： C12N15/8509 , A01K67/0339 , C07K14/005 , C07K14/4703 , C07K14/705 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
摘要翻译： 公开了一类新颖的蛋白质，信号素，编码信号素的核酸，信号素肽，以及使用信号素和信号素编码核酸的方法。 信号肽和受体激动剂和拮抗剂提供神经细胞生长和再生的有效调节剂。 本发明提供药物组合物，用于筛选细胞生长/分化调节物的化学文库的方法; 用于遗传作图的信号素基因衍生的核酸，作为相关基因的探针，以及作为遗传神经疾病的诊断试剂; 特异性细胞和动物系统用于神经疾病治疗的发展。
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公开(公告)号：US20080312158A1
公开(公告)日：2008-12-18
申请号：US11763394
申请日：2007-06-14
IPC分类号： A61K38/00 , C07K7/00 , C07K16/18 , C12N15/11 , C12N5/06 , A61P25/00 , A01K67/027 , C12P21/04 , G01N33/566 , C12Q1/68
CPC分类号： C12N15/8509 , A01K67/0339 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C07K14/005 , C07K14/4703 , C07K14/705 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
摘要翻译： 公开了一类新颖的蛋白质，信号素，编码信号素的核酸，信号素肽，以及使用信号素和信号素编码核酸的方法。 信号肽和受体激动剂和拮抗剂提供神经细胞生长和再生的有效调节剂。 本发明提供药物组合物，用于筛选细胞生长/分化调节物的化学文库的方法; 用于遗传作图的信号素基因衍生的核酸，作为相关基因的探针，以及作为遗传神经疾病的诊断试剂; 特异性细胞和动物系统用于神经疾病治疗的发展。
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公开(公告)号：US06344544B1
公开(公告)日：2002-02-05
申请号：US09060610
申请日：1998-04-15
IPC分类号： A61K39395
CPC分类号： C12N15/8509 , A01K67/0339 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C07K14/005 , C07K14/4703 , C07K14/705 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
摘要翻译： 公开了一类新颖的蛋白质，信号素，编码信号素的核酸，信号素肽，以及使用信号素和信号素编码核酸的方法。 信号肽和受体激动剂和拮抗剂提供神经细胞生长和再生的有效调节剂。 本发明提供药物组合物，用于筛选细胞生长/分化调节物的化学文库的方法; 用于遗传作图的信号素基因衍生的核酸，作为相关基因的探针，以及作为遗传神经疾病的诊断试剂; 特异性细胞和动物系统用于神经疾病治疗的发展。
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公开(公告)号：US07153936B2
公开(公告)日：2006-12-26
申请号：US10067632
申请日：2002-02-04
CPC分类号： C12N15/8509 , A01K67/0339 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C07K14/005 , C07K14/4703 , C07K14/705 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
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公开(公告)号：US20070033669A1
公开(公告)日：2007-02-08
申请号：US11580373
申请日：2006-10-12
申请人： Corey Goodman , Alex Kolodkin , David Matthes , David Bentley , Timothy O'Connor
发明人： Corey Goodman , Alex Kolodkin , David Matthes , David Bentley , Timothy O'Connor
CPC分类号： C12N15/8509 , A01K67/0339 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C07K14/005 , C07K14/4703 , C07K14/705 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
摘要翻译： 公开了一类新颖的蛋白质，信号素，编码信号素的核酸，信号素肽，以及使用信号素和信号素编码核酸的方法。 信号肽和受体激动剂和拮抗剂提供神经细胞生长和再生的有效调节剂。 本发明提供药物组合物，用于筛选细胞生长/分化调节物的化学文库的方法; 用于遗传作图的信号素基因衍生的核酸，作为相关基因的探针，以及作为遗传神经疾病的诊断试剂; 特异性细胞和动物系统用于神经疾病治疗的发展。
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