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![2-pyrrolidin-2-yl-[1,3,4]-oxadiazole compounds and their use as anti-depressants](/abs-image/US/2006/09/12/US07105538B2/abs.jpg.150x150.jpg)
1.发明授权2-pyrrolidin-2-yl-[1,3,4]-oxadiazole compounds and their use as anti-depressants 失效2-吡咯烷-2-基 - [1,3,4] - 恶二唑化合物及其作为抗抑郁剂的用途公开(公告)号：US07105538B2
公开(公告)日：2006-09-12
申请号：US11066981
申请日：2005-02-28
IPC分类号： A61K31/4725 , A61K31/44 , A61K31/4245 , C07D217/18 , C07D413/04 , C07D271/10
CPC分类号： C07D413/04 , C07D413/14
摘要： Substituted 2-pyrrolidin-2-yl compounds corresponding to formula I a method for their production, pharmaceutical compositions containing them, and methods of using them, especially for treating pain and/or depression.
摘要翻译： 对应于式I的取代的2-吡咯烷-2-基化合物其制备方法，含有它们的药物组合物及其使用方法，特别是用于治疗疼痛和/或抑郁症。
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公开(公告)号：US07271192B2
公开(公告)日：2007-09-18
申请号：US10861426
申请日：2004-06-07
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D493/08
摘要： Novel 2-pyrrolidin-2-yl-1H-indole compounds corresponding to formula (I) wherein R1, R2, R3 and R4 have the meanings given in the description, and pharmaceutical compositions containing these compounds, as well as processes for the preparation of such compounds and intermediate products of this process, and related methods of treatment.
摘要翻译： 对应于式（I）的新的2-吡咯烷-2-基-1H-吲哚化合物，其中R 1，R 2，R 3和R 3， R 4具有本说明书中给出的含义，含有这些化合物的药物组合物，以及该方法的这种化合物和中间产物的制备方法以及相关的治疗方法。
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公开(公告)号：US20050014815A1
公开(公告)日：2005-01-20
申请号：US10861426
申请日：2004-06-07
IPC分类号： A61K31/352 , A61K31/404 , A61K31/4155 , A61K31/422 , A61K31/4439 , A61K31/472 , A61P3/10 , A61P9/10 , A61P17/02 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P37/00 , A61P43/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D493/08 , C07D493/18 , C07
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D493/08
摘要： Novel 2-pyrrolidin-2-yl-1H-indole compounds corresponding to formula (I) wherein R1, R2, R3 and R4 have the meanings given in the description, and pharmaceutical compositions containing these compounds, as well as processes for the preparation of such compounds and intermediate products of this process, and related methods of treatment.
摘要翻译： 对应于式（I）的新的2-吡咯烷-2-基-1H-吲哚化合物，其中R 1，R 2，R 3和R 4具有说明书中给出的含义，药物组合物 含有这些化合物的方法，以及该方法的这些化合物和中间产物的制备方法以及相关的治疗方法。
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![2-Pyrrolidin-2-yl-[1,3,4]-oxadiazole compounds and their use as anti-depressants](/abs-image/US/2005/08/25/US20050187260A1/abs.jpg.150x150.jpg)
4.发明申请2-Pyrrolidin-2-yl-[1,3,4]-oxadiazole compounds and their use as anti-depressants 失效2-吡咯烷-2-基 - [1,3,4] - 恶二唑化合物及其作为抗抑郁剂的用途公开(公告)号：US20050187260A1
公开(公告)日：2005-08-25
申请号：US11066981
申请日：2005-02-28
IPC分类号： A61K31/4245 , A61K31/4439 , A61P25/24 , C07D413/04 , C07D413/14
CPC分类号： C07D413/04 , C07D413/14
摘要： Substituted 2-pyrrolidin-2-yl compounds corresponding to formula I a method for their production, pharmaceutical compositions containing them, and methods of using them, especially for treating pain and/or depression.
摘要翻译： 对应于式I的取代的2-吡咯烷-2-基化合物其制备方法，含有它们的药物组合物及其使用方法，特别是用于治疗疼痛和/或抑郁症。
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![Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds](/abs-image/US/2007/10/25/US20070249631A1/abs.jpg.150x150.jpg)
5.发明申请Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds 有权取代的5,6,7,8-四氢吡啶并[4,3-d]嘧啶-2-基化合物和5,6,7,8-四氢喹唑啉-2-基化合物公开(公告)号：US20070249631A1
公开(公告)日：2007-10-25
申请号：US11588238
申请日：2006-10-27
申请人： Stefan Oberboersch , Bernd Sundermann , Corinna Sundermann , Michael Haurand , Hagen-Heinrich Hennies , Edward Bijsterveld
发明人： Stefan Oberboersch , Bernd Sundermann , Corinna Sundermann , Michael Haurand , Hagen-Heinrich Hennies , Edward Bijsterveld
IPC分类号： C07D471/04 , C07D239/70 , C07D471/00
CPC分类号： C07D239/84 , C07D409/12 , C07D471/04
摘要： Substituted 5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl and 5,6,7,8-tetrahydro-quinazolin-2-yl compounds, corresponding to formula I processes for the production thereof, pharmaceutical preparations containing these compounds the use thereof for the production of pharmaceutical preparations and related method of treating or inhibiting certain disorders or conditions, including pain.
摘要翻译： 取代的5,6,7,8-四氢 - 吡啶并[4,3-d]嘧啶-2-基和5,6,7,8-四氢 - 喹唑啉-2-基化合物，对应于式I生产方法 含有这些化合物的药物制剂用于制备药物制剂及其治疗或抑制某些疾病或病症（包括疼痛）的相关方法。
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6.发明授权公开(公告)号：US06943181B2
公开(公告)日：2005-09-13
申请号：US10751737
申请日：2004-01-05
IPC分类号： A61K31/365 , A61K31/4155 , A61K31/443 , A61K31/473 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/517 , A61P3/10 , A61P25/16 , A61P25/28 , A61P31/10 , A61P35/00 , A61K31/4525 , A61K31/4164 , A61K31/4709
CPC分类号： A61K31/443 , A61K31/365 , A61K31/4155 , A61K31/473 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/517
摘要： The invention relates to the use of substituted gamma-lactone compounds in the production of medicines for treating migraines, septic shock, neurodegenerative diseases, such as multiple sclerosis, Parkinsons, Alzheimers or Huntingtons disease, inflammations and related pain, cerebral ischaemia, diabetes, meningitis, arteriosclerosis, cancer, mycosis, or for healing wounds.
摘要翻译： 本发明涉及取代的γ-内酯化合物在制备用于治疗偏头痛，败血性休克，神经变性疾病如多发性硬化，帕金森，阿尔茨海默病或亨廷顿病，炎症和相关疼痛，脑缺血，糖尿病，脑膜炎 ，动脉硬化，癌症，真菌病或愈合伤口。
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![Substituted 1,4,8-triazaspiro [4,5]decan-2-one compounds](/abs-image/US/2011/05/31/US07951815B2/abs.jpg.150x150.jpg)
公开(公告)号：US07951815B2
公开(公告)日：2011-05-31
申请号：US11525057
申请日：2006-09-22
申请人： Corinna Sundermann , Bernd Sundermann , Stefan Ober-Boersch , Werner Englberger , Hagen-Heinrich Hennies
发明人： Corinna Sundermann , Bernd Sundermann , Stefan Ober-Boersch , Werner Englberger , Hagen-Heinrich Hennies
IPC分类号： A61K31/438 , C07D471/10
CPC分类号： C07D471/10
摘要： Novel 1,4,8-triazaspiro[4,5]decan-2-one compounds corresponding to formula I processes for the preparation thereof, related methods of treatment and pharmaceutical formulations containing such compounds.
摘要翻译： 对应于式I的1,4,8-三氮杂螺[4,5]癸-2-酮化合物的制备方法，相关的治疗方法和含有这些化合物的药物制剂。
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![Substituted imidazo[1,2-a]pyridine compounds and pharmaceutical preparations containing substituted imidazo[1,2-a]pyridine compounds](/abs-image/US/2009/09/22/US07592351B2/abs.jpg.150x150.jpg)
8.发明授权Substituted imidazo[1,2-a]pyridine compounds and pharmaceutical preparations containing substituted imidazo[1,2-a]pyridine compounds 失效取代的咪唑并[1,2-a]吡啶化合物和含有取代的咪唑并[1,2-a]吡啶化合物的药物制剂公开(公告)号：US07592351B2
公开(公告)日：2009-09-22
申请号：US11589146
申请日：2006-10-30
IPC分类号： A01N43/42 , A61K31/44 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04
摘要： Substituted imidazo[1,2-a]pyridine compounds, a process for the production thereof, pharmaceutical preparations containing such compounds and methods of using such substituted imidazo[1,2-a]pyridine compounds to treat and/or inhibit various diseases or pathological conditions.
摘要翻译： 取代的咪唑并[1,2-a]吡啶化合物，其制备方法，含有这些化合物的药物制剂和使用这种取代的咪唑并[1,2-a]吡啶化合物治疗和/或抑制各种疾病或病理学 条件。
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![Substituted C-imidazo [1,2-α] pyridin-3-yl-methylamines](/abs-image/US/2008/03/18/US07345055B2/abs.jpg.150x150.jpg)
公开(公告)号：US07345055B2
公开(公告)日：2008-03-18
申请号：US11101471
申请日：2005-04-08
IPC分类号： A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02
CPC分类号： C07D471/04
摘要： Novel C-imidazo[1,2-α]pyridin-3-yl-methylamine compounds corresponding to formula I, wherein R1-R6 have the meanings provided in the description. Pharmaceutical compositions containing these compounds are also provided, as well as methods of using these compounds for treating or inhibiting various illnesses or other conditions.
摘要翻译： 对应于式I的新颖的C-咪唑并[1,2-α]吡啶-3-基 - 甲胺化合物，其中R 1至R 6具有式 描述。 还提供含有这些化合物的药物组合物，以及使用这些化合物治疗或抑制各种疾病或其他病症的方法。
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![Substituted C-imiadazol[1,2-a] pyridin-3-yl-methylamines](/abs-image/US/2005/10/27/US20050239822A1/abs.jpg.150x150.jpg)
公开(公告)号：US20050239822A1
公开(公告)日：2005-10-27
申请号：US11100535
申请日：2005-04-07
IPC分类号： A61P25/00 , A61P35/00 , C07D471/04 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： Substituted C-imidazo [1,2-a]pyridine-3-yl methylamines and physiologically acceptable salts thereof, a method for the production thereof, pharmaceutical compositions containing these compounds, and pharmaceutical uses thereof, e.g., as NO synthase inhibitors.
摘要翻译： 取代的C-咪唑并[1,2-a]吡啶-3-基甲胺及其生理学上可接受的盐，其制备方法，含有这些化合物的药物组合物及其药物用途，例如NO合成酶抑制剂。
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