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公开(公告)号:US10731187B2
公开(公告)日:2020-08-04
申请号:US15119825
申请日:2015-02-19
发明人: Gernot Jaeger , Jorgen Magnus , Amgad Salah Moussa , Guenter Olf , Giulio Lolli , Swantje Behnken , Jung-Won Youn , Mohammad Yalfani , Georg Sprenger
IPC分类号: C12P13/00 , C12P13/02 , C12P13/04 , C12N15/78 , C12N15/77 , C12N15/70 , C12N9/90 , C12N9/10 , C12N15/52
摘要: The invention provides a recombinant microbial host cell capable of converting a raw material comprising a fermentable carbon substrate to o-aminobenzoate biologically. The invention further provides a method for producing aniline, comprising the steps of: a) producing o-aminobenzoate by fermentation of a raw material comprising at least one fermentable carbon substrate using the recombinant microbial host cell of the capable of converting said raw material comprising at least one fermentable carbon substrate to o-aminobenzoate biologically, wherein said o-aminobenzoate comprises anthranilate anion, b) converting said o-aminobenzoate from said anthranilate anion to anthranilic acid by acid protonation, c) recovering said anthranilic acid by precipitation or by dissolving in an organic solvent, and d) converting said anthranilic acid to aniline by thermal decarboxylation in an organic solvent.
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公开(公告)号:US10968466B2
公开(公告)日:2021-04-06
申请号:US16469746
申请日:2017-12-18
IPC分类号: C12P13/00 , C07C209/78 , C07C227/40 , C07C231/02 , C07C245/02 , C08G12/08 , C08G73/02
摘要: The present invention relates to a process for preparing aminobenzoic acid or an aminobenzoic acid conversion product, comprising the steps of: (I) providing an aqueous solution of aminobenzoic acid using a fermentation process; (II) adsorbing aminobenzoic acid; (III) desorbing aminobenzoic acid at a pH in the range from −0.8 to 3.0, preferably −0.5 to 3.0, more preferably 0.1 to 3.0, very preferably 0.5 to 2.5, very exceptionally preferably 1.0 to 2.0; (IV) obtaining the aminobenzoic acid from the desorbate obtained in step (III); (V) optionally further converting the aminobenzoic acid obtained in step (IV) to an aminobenzoic acid conversion product.
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公开(公告)号:US10703709B2
公开(公告)日:2020-07-07
申请号:US16311205
申请日:2017-06-27
IPC分类号: C07C209/68 , C07C209/78 , C12P13/00
摘要: The invention relates to a method for producing aniline or products that are obtained by further chemical reaction of aniline (aniline derivatives), involving decarboxylation of aminobenzoic acid, particularly ortho-aminobenzoic acid, in which one portion of the previously formed crude aniline is recirculated in the decarboxylation step. The aminobenzoic acid is obtained enzymatically or chemically, preferably enzymatically.
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公开(公告)号:US20170152535A1
公开(公告)日:2017-06-01
申请号:US15119825
申请日:2015-02-19
发明人: Gernot Jaeger , Jorgen Magnus , Amgad Salah Moussa , Guenter Olf , Giulio Lolli , Swantje Behnken , Jung-Won Youn , Mohammad Yalfani , Georg Sprenger
CPC分类号: C12P13/001 , C12N9/1077 , C12N9/90 , C12N15/52 , C12N15/70 , C12N15/77 , C12N15/78 , C12P13/02 , C12P13/04 , C12Y204/02018 , C12Y504/99005
摘要: The invention provides a recombinant microbial host cell capable of converting a raw material comprising a fermentable carbon substrate to o-aminobenzoate biologically. The invention further provides a method for producing aniline, comprising the steps of: a) producing o-aminobenzoate by fermentation of a raw material comprising at least one fermentable carbon substrate using the recombinant microbial host cell of the capable of converting said raw material comprising at least one fermentable carbon substrate to o-aminobenzoate biologically, wherein said o-aminobenzoate comprises anthranilate anion, b) converting said o-aminobenzoate from said anthranilate anion to anthranilic acid by acid protonation, c) recovering said anthranilic acid by precipitation or by dissolving in an organic solvent, and d) converting said anthranilic acid to aniline by thermal decarboxylation in an organic solvent.
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