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公开(公告)号：US5939295A
公开(公告)日：1999-08-17
申请号：US627696
申请日：1996-03-29
CPC分类号： C12N15/52 , C12P13/227 , C12Y204/02018 , C12Y401/01048 , C12Y401/03027 , C12Y402/0102 , C12Y402/03004 , C12Y503/01024
摘要： An improved recombinant DNA plasmid composed of a DNA vector and other DNA fragments containing the tryptophan operon from E. coli, the aroG gene from E. coli and the serA gene from E. coli is shown. The plasmid is transformed into a microorganism belonging to Escherichia coli, and the microorganisms are cultured in a medium and the L-tryptophan accumulated in the culture is recovered.
摘要翻译： 显示了由DNA载体和含有来自大肠杆菌的色氨酸操纵子的其他DNA片段，来自大肠杆菌的aroG基因和来自大肠杆菌的serA基因的改良的重组DNA质粒。 将质粒转化到属于大肠杆菌的微生物中，并将微生物培养在培养基中，并回收在培养物中积聚的L-色氨酸。
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公开(公告)号：US20230172997A1
公开(公告)日：2023-06-08
申请号：US17923955
申请日：2021-05-26
IPC分类号： A61K35/74 , C12N1/20 , C12N15/52 , C12N15/70 , C12P17/10 , C12N9/06 , C12N9/10 , C12N9/88 , A61P3/00
CPC分类号： A61K35/74 , C12N1/20 , C12N15/52 , C12N15/70 , C12P17/10 , C12N9/0016 , C12N9/1077 , C12N9/1085 , C12N9/88 , A61P3/00 , C12Y402/0102 , C12Y401/01074 , C12Y104/01019 , C12Y205/01054 , C12Y401/03027 , C12Y401/01048 , C12Y204/02018 , C12R2001/19
摘要： The present disclosure provides recombinant bacteria for production of indole-3-acetic acid (IAA). Pharmaceutical compositions and methods of treating diseases are also included.
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3.发明申请MICROORGANISMS HAVING L-TRYPTOPHAN PRODUCTIVITY AND A METHOD FOR PRODUCTION OF L-TRYPTOPHAN USING SAME (AS AMENDED) 有权具有L-酪氨酸生产力的微生物和使用它的L-酪氨酸生产方法（如修改）公开(公告)号：US20160153014A1
公开(公告)日：2016-06-02
申请号：US14784621
申请日：2014-04-16
发明人： Hyung Joon Kim , Ju No Jang , Kyung Rim Kim , Keun Cheol Lee , Young Bin Hwang , Hyeong Pyo Hong
CPC分类号： C12P13/227 , C12N9/1077 , C12Y204/02018 , Y02P20/52
摘要： The present invention relates to a microorganism of the genus Escherichia having enhanced L-tryptophan productivity, which has been modified to express yeast anthranilate phosphoribosyltransferase in order to be able to produce L-tryptophan at high concentration, and to a method for producing L-tryptophan, comprising a step of culturing the microorganism. The microorganism of the genus Escherichia can produce L-tryptophan, and thus can be advantageously used in the pharmaceutical industry and the feed industry, particularly for animal feed.
摘要翻译： 本发明涉及具有增强的L-色氨酸生产力的埃希氏菌属微生物，其已被修饰以表达酵母邻氨基苯甲酸酯磷酸核糖转移酶，以便能够产生高浓度的L-色氨酸，以及L-色氨酸的生产方法 包括培养微生物的步骤。 埃希氏菌属的微生物可产生L-色氨酸，因此可有利地用于制药工业和饲料工业，尤其用于动物饲料。
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公开(公告)号：US20230407351A1
公开(公告)日：2023-12-21
申请号：US18250989
申请日：2021-10-28
申请人： PILI
发明人： LUCIE CREPIN , CAROLINE SCHIAVON
CPC分类号： C12P13/04 , C12N15/70 , C12N9/1022 , C12Y202/01001 , C12N9/1077 , C12Y204/02018 , C12N9/88 , C12Y401/01048 , C12Y402/0102 , C12N9/90 , C12Y503/01024 , C12N9/93 , C12Y603/05002 , C12N2800/101
摘要： The present invention relates to a recombinant bacterium genetically modified to produce anthranilic acid and being able to grow in a culture medium lacking tryptophan. It also relates to a method for producing anthranilic acid using said recombinant bacterium.
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公开(公告)号：US20170152535A1
公开(公告)日：2017-06-01
申请号：US15119825
申请日：2015-02-19
发明人： Gernot Jaeger , Jorgen Magnus , Amgad Salah Moussa , Guenter Olf , Giulio Lolli , Swantje Behnken , Jung-Won Youn , Mohammad Yalfani , Georg Sprenger
CPC分类号： C12P13/001 , C12N9/1077 , C12N9/90 , C12N15/52 , C12N15/70 , C12N15/77 , C12N15/78 , C12P13/02 , C12P13/04 , C12Y204/02018 , C12Y504/99005
摘要： The invention provides a recombinant microbial host cell capable of converting a raw material comprising a fermentable carbon substrate to o-aminobenzoate biologically. The invention further provides a method for producing aniline, comprising the steps of: a) producing o-aminobenzoate by fermentation of a raw material comprising at least one fermentable carbon substrate using the recombinant microbial host cell of the capable of converting said raw material comprising at least one fermentable carbon substrate to o-aminobenzoate biologically, wherein said o-aminobenzoate comprises anthranilate anion, b) converting said o-aminobenzoate from said anthranilate anion to anthranilic acid by acid protonation, c) recovering said anthranilic acid by precipitation or by dissolving in an organic solvent, and d) converting said anthranilic acid to aniline by thermal decarboxylation in an organic solvent.
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6.发明授权Microorganisms having L-tryptophan productivity and a method for production of L-tryptophan using same 有权具有L-色氨酸生产力的微生物和使用其的L-色氨酸的生产方法公开(公告)号：US09562246B2
公开(公告)日：2017-02-07
申请号：US14784621
申请日：2014-04-16
发明人： Hyung Joon Kim , Ju No Jang , Kyung Rim Kim , Keun Cheol Lee , Young Bin Hwang , Hyeong Pyo Hong
CPC分类号： C12P13/227 , C12N9/1077 , C12Y204/02018 , Y02P20/52
摘要： The present invention relates to a microorganism of the genus Escherichia having enhanced L-tryptophan productivity, which has been modified to express yeast anthranilate phosphoribosyltransferase in order to be able to produce L-tryptophan at high concentration, and to a method for producing L-tryptophan, comprising a step of culturing the microorganism. The microorganism of the genus Escherichia can produce L-tryptophan, and thus can be advantageously used in the pharmaceutical industry and the feed industry, particularly for animal feed.
摘要翻译： 本发明涉及具有增强的L-色氨酸生产力的埃希氏菌属微生物，其已被修饰以表达酵母邻氨基苯甲酸酯磷酸核糖转移酶，以便能够产生高浓度的L-色氨酸，以及L-色氨酸的生产方法 包括培养微生物的步骤。 埃希氏菌属的微生物可产生L-色氨酸，因此可有利地用于制药工业和饲料工业，尤其用于动物饲料。
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