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公开(公告)号：US5674704A
公开(公告)日：1997-10-07
申请号：US236918
申请日：1994-05-06
IPC分类号： A61K38/00 , C07K14/52 , C07K14/715 , C12N15/12 , C07K14/705 , C12N15/63
CPC分类号： C07K14/52 , C07K14/715 , A61K38/00 , C07K2319/00
摘要： Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the novel polypeptides by cultivating such transformed host cells. Soluble forms of the 4-1BB-L or 4-1BB polypeptides are derived from the extracellular domains thereof.
摘要翻译： 提供新型4-1BB配体（4-1BB-L）多肽和与4-1BB-L结合的命名为4-1BB的人细胞表面受体。 公开了分离的4-1BB-L编码和人4-1BB编码DNA序列，包含分离的DNA序列的重组表达载体和用重组表达载体转化的宿主细胞，以及通过培养这些DNA来生产新多肽的方法 转化的宿主细胞。 4-1BB-L或4-1BB多肽的可溶形式衍生自其胞外结构域。
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公开(公告)号：US5480981A
公开(公告)日：1996-01-02
申请号：US225989
申请日：1994-04-12
IPC分类号： A61K38/00 , C07K14/705 , C07K16/00 , C07K16/28 , C12N15/19 , C07H21/04 , C07K1/00 , C07K14/52 , C12N15/63
CPC分类号： C07K16/2875 , C07K14/70575 , C07K14/70578 , C07K16/00 , C07K16/2878 , A61K38/00 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/036 , C07K2319/30 , C07K2319/32 , Y10S514/883
摘要： There is disclosed a polypeptide (CD30-L) and DNA sequences, vectors and transformed host cells useful in providing CD30-L polypeptides. The CD30-L polypeptide binds to the receptor known as CD30, which is expressed on a number of cell types, among which are Hodgkin's Disease tumor cells, large cell anaplastic lymphoma cells, adult T-cell leukemia (T-ALL) cells, and a number of other malignant cell types. CD30-L polypeptides find use as carriers for delivering diagnostic and cytotoxic agents to cells expressing the CD30 receptor.
摘要翻译： 公开了可用于提供CD30-L多肽的多肽（CD30-L）和DNA序列，载体和转化的宿主细胞。 CD30-L多肽与称为CD30的受体结合，该受体在许多细胞类型上表达，其中包括霍奇金病肿瘤细胞，大细胞间变性淋巴瘤细胞，成人T细胞白血病（T-ALL）细胞，以及 许多其他恶性细胞类型。 CD30-L多肽可用作将诊断和细胞毒性剂递送至表达CD30受体的细胞的载体。
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公开(公告)号：US20090270592A1
公开(公告)日：2009-10-29
申请号：US11976382
申请日：2007-10-24
IPC分类号： C07K14/435
CPC分类号： G01N33/6863 , A61K38/00 , C07K14/7151 , G01N2333/525 , G01N2500/02 , G01N2800/26
摘要： Purified protein preparations comprising tumor necrosis factor are disclosed.
摘要翻译： 公开了包含肿瘤坏死因子的纯化蛋白质制剂。
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公开(公告)号：US07057022B2
公开(公告)日：2006-06-06
申请号：US10420785
申请日：2003-04-23
CPC分类号： G01N33/6863 , A61K38/00 , C07K14/7151 , G01N2333/525 , G01N2500/02 , G01N2800/26
摘要： Tumor necrosis factor receptor proteins, DNAs and expression vectors encoding TNF receptors, and processes for producing TNF receptors as products of recombinant cell culture, are disclosed.
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公开(公告)号：US5712155A
公开(公告)日：1998-01-27
申请号：US346555
申请日：1994-11-29
IPC分类号： C12P21/02 , A61K31/00 , A61K38/00 , A61K39/395 , A61P9/00 , A61P35/00 , A61P37/00 , A61P37/02 , C07K14/00 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/24 , C07K16/28 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/08 , C12R1/865 , C12R1/91 , G01N33/53 , G01N33/566 , G01N33/574 , C07K14/435 , C12N15/63
CPC分类号： G01N33/6863 , C07K14/7151 , A61K38/00 , G01N2333/525 , G01N2500/02 , G01N2800/26
摘要： Tumor necrosis factor receptor DNAs and expression vectors encoding TNF receptors, and processes for producing TNF receptors as products of recombinant cell culture, are disclosed.
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6.发明授权
公开(公告)号：US5359039A
公开(公告)日：1994-10-25
申请号：US89458
申请日：1993-07-09
申请人： Craig A. Smith , Raymond G. Goodwin
发明人： Craig A. Smith , Raymond G. Goodwin
IPC分类号： A61K38/00 , C07K14/065 , C07K13/00 , C07K15/04
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/02 , C07K2319/30 , C07K2319/40 , C12N2710/24122 , Y10S530/826
摘要： Isolated viral proteins, and pharmaceutical compositions made therefrom, are disclosed which are capable of binding to Tumor Necrosis Factor, thereby functioning as Tumor Necrosis Factor antagonists. Also disclosed are processes for preparing isolated viral protein cytokine antagonists.
摘要翻译： 公开了分离的病毒蛋白质和由其制备的药物组合物，其能够结合肿瘤坏死因子，从而起肿瘤坏死因子拮抗剂的作用。 还公开了制备分离的病毒蛋白细胞因子拮抗剂的方法。
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公开(公告)号：US06667039B1
公开(公告)日：2003-12-23
申请号：US09628126
申请日：2000-07-28
IPC分类号： A61K39385
CPC分类号： C07K16/2875 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/00 , C07K16/2878 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/036 , C07K2319/30 , C07K2319/32 , Y10S514/883
摘要： There is disclosed a polypeptide (CD30-L) and DNA sequences, vectors and transformed host cells useful in providing CD30-L polypeptides. The CD30-L polypeptide binds to the receptor known as CD30, which is expressed on a number of cell types, among which are Hodgkin's Disease tumor cells, large cell anaplasdic lymphoma cells, adult T-cell leukemia (T-ALL) cells, and a number of other malignant cell types. CD30-L polypeptides find use as carriers for delivering diagnostic and cytotoxic agents to cells expressing the CD30 receptor.
摘要翻译： 公开了可用于提供CD30-L多肽的多肽（CD30-L）和DNA序列，载体和转化的宿主细胞。 CD30-L多肽与称为CD30的受体结合，该受体在许多细胞类型上表达，其中包括霍奇金氏肿瘤细胞，大细胞非平滑淋巴瘤细胞，成人T细胞白血病（T-ALL）细胞，和 许多其他恶性细胞类型。 CD30-L多肽可用作将诊断和细胞毒性剂递送至表达CD30受体的细胞的载体。
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公开(公告)号：US06224867B1
公开(公告)日：2001-05-01
申请号：US08953268
申请日：1997-10-17
IPC分类号： C07K1646
摘要： Tumor necrosis factor receptor proteins, DNAs and expression vectors encoding TNF receptors, and processes for producing TNF receptors as products of recombinant cell culture, are disclosed.
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公开(公告)号：US6143869A
公开(公告)日：2000-11-07
申请号：US79785
申请日：1998-05-15
IPC分类号： A61K38/00 , C07K14/705 , C07K16/00 , C07K16/28 , C12N15/19 , C07K14/435
CPC分类号： C07K16/2875 , C07K14/70575 , C07K14/70578 , C07K16/00 , C07K16/2878 , A61K38/00 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/036 , C07K2319/30 , C07K2319/32 , Y10S514/883
摘要： There is disclosed a polypeptide (CD30-L) and DNA sequences, vectors and transformed host cells useful in providing CD30-L polypeptides. The CD30-L polypeptide binds to the receptor known as CD30, which is expressed on a number of cell types, among which are Hodgkin's Disease tumor cells, large cell anaplastic lymphoma cells, adult T-cell leukemia (T-ALL) cells, and a number of other malignant cell types. CD30-L polypeptides find use as carriers for delivering diagnostic and cytotoxic agents to cells expressing the CD30 receptor.
摘要翻译： 公开了可用于提供CD30-L多肽的多肽（CD30-L）和DNA序列，载体和转化的宿主细胞。 CD30-L多肽与称为CD30的受体结合，该受体在许多细胞类型上表达，其中包括霍奇金病肿瘤细胞，大细胞间变性淋巴瘤细胞，成人T细胞白血病（T-ALL）细胞，以及 许多其他恶性细胞类型。 CD30-L多肽可用作将诊断和细胞毒性剂递送至表达CD30受体的细胞的载体。
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公开(公告)号：US5464938A
公开(公告)日：1995-11-07
申请号：US292549
申请日：1994-08-18
申请人： Craig A. Smith , Raymond G. Goodwin
发明人： Craig A. Smith , Raymond G. Goodwin
IPC分类号： A61K38/00 , C07K14/065
CPC分类号： C07K14/005 , A61K38/00 , C12N2710/24022
摘要： Isolated viral proteins, and pharmaceutical compositions made therefrom, are disclosed which are capable of binding to cytokines, thereby functioning as cytokine antagonists. Also disclosed are processes for preparing isolated vital protein cytokine antagonists.
摘要翻译： 公开了分离的病毒蛋白质和由其制备的药物组合物，其能够结合细胞因子，从而起细胞因子拮抗剂的作用。 还公开了制备分离的重要蛋白质细胞因子拮抗剂的方法。
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