-
公开(公告)号：US20100143360A1
公开(公告)日：2010-06-10
申请号：US12258109
申请日：2008-10-24
申请人： Craig Rosen , Jing-Shan Hu , Liang Cao
发明人： Craig Rosen , Jing-Shan Hu , Liang Cao
IPC分类号： A61K39/395 , G01N33/53 , C12N9/96 , C12N5/16 , C07K16/00
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.
摘要翻译： 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还公开了使用这种多肽刺激伤口愈合和维持血管组织修复的方法。 还提供了使用拮抗剂抑制肿瘤生长，炎症和治疗糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。 还公开了用于检测VEGF2编码序列中的突变和来自宿主的样品中VEGF2蛋白浓度变化的诊断方法。
-
公开(公告)号：US20060025331A1
公开(公告)日：2006-02-02
申请号：US11233119
申请日：2005-09-23
申请人： Jing-Shan Hu , Craig Rosen , Liang Cao
发明人： Jing-Shan Hu , Craig Rosen , Liang Cao
IPC分类号： A61K38/18 , A61K39/395
CPC分类号： A61K38/1866 , A61K38/179 , A61K2039/505 , C07K16/22
摘要： Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA (RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
-
公开(公告)号：US20050287143A1
公开(公告)日：2005-12-29
申请号：US11211724
申请日：2005-08-26
申请人： Craig Rosen , Jing-Shan Hu , Liang Cao
发明人： Craig Rosen , Jing-Shan Hu , Liang Cao
CPC分类号： G01N33/68 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/52 , C07K2319/00 , C12N2799/026 , G01N2333/515
摘要： Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.
摘要翻译： 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还公开了使用这种多肽刺激伤口愈合和维持血管组织修复的方法。 还提供了使用拮抗剂抑制肿瘤生长，炎症和治疗糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。 还公开了用于检测VEGF2编码序列中的突变和来自宿主的样品中VEGF2蛋白浓度变化的诊断方法。
-
公开(公告)号：US20050256050A1
公开(公告)日：2005-11-17
申请号：US11153880
申请日：2005-06-16
申请人： Jing-Shan Hu , Craig Rosen , Liang Cao
发明人： Jing-Shan Hu , Craig Rosen , Liang Cao
IPC分类号： A61K38/00 , A61K38/18 , A61K39/00 , A61K48/00 , C07H21/04 , C07K14/52 , C12N15/09 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/52 , C07K2319/00 , C12N2799/026
摘要： Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译： 公开了人VEGF2多肽，生物活性，诊断学或治疗上有用的片段，类似物或衍生物，以及编码这种VEGF2多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。
-
公开(公告)号：US20050176103A1
公开(公告)日：2005-08-11
申请号：US11067015
申请日：2005-02-28
申请人： Jing-Shan Hu , Craig Rosen , Liang Cao
发明人： Jing-Shan Hu , Craig Rosen , Liang Cao
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/52 , C12N1/21 , C12N15/18 , C07K14/515 , C07H21/04
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA (RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译： 公开了人VEGF2多肽，生物活性，诊断学或治疗上有用的片段，类似物或衍生物，以及编码这种VEGF2多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。
-
公开(公告)号：US06608182B1
公开(公告)日：2003-08-19
申请号：US08465968
申请日：1995-06-06
申请人： Craig Rosen , Jing-Shan Hu , Liang Cao
发明人： Craig Rosen , Jing-Shan Hu , Liang Cao
IPC分类号： A61K3824
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to polypeptides comprising amino acids 85 to 165 of SEQ ID NO:2, as well as polynucleotides which encode these polypeptides. Also provided are methods of treatment using these polypeptides.
摘要翻译： 本发明涉及包含SEQ ID NO：2的氨基酸85至165的多肽，以及编码这些多肽的多核苷酸。 还提供了使用这些多肽的治疗方法。
-
公开(公告)号：US07227005B1
公开(公告)日：2007-06-05
申请号：US09257272
申请日：1999-02-25
申请人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
发明人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译： 公开了人VEGF2多肽，生物活性，诊断学或治疗上有用的片段，类似物或衍生物，以及编码这种VEGF2多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。
-
公开(公告)号：US6040157A
公开(公告)日：2000-03-21
申请号：US42105
申请日：1998-03-13
申请人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
发明人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeuticall sefl fragments, analogs, or derivatives thereof, and DNA (RNA) enco such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译： 公开了人类VEGF2多肽，生物学活性，诊断学或治疗学的sefl片段，类似物或其衍生物，和遇到这种VEGF2多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。
-
公开(公告)号：US20090192088A1
公开(公告)日：2009-07-30
申请号：US12396033
申请日：2009-03-02
申请人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
发明人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
IPC分类号： A61K38/18 , C07H21/04 , C12N15/63 , C12N5/10 , C12N15/09 , C07K14/475 , C07K16/22 , A61P9/00
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Such polypeptides may be combined with a suitable pharmaceutical carrier or diluent to provide diagnostic, therapeutic and/or prophylactic effects against various diseases. Also provided are methods of using the antibodies and antagonists to inhibit the action of VEGF2 for therapeutic purposes.
摘要翻译： 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以与合适的药物载体或稀释剂组合以提供针对各种疾病的诊断，治疗和/或预防效果。 还提供了使用抗体和拮抗剂抑制VEGF2作用于治疗目的的作用的方法。
-
公开(公告)号：US07153827B1
公开(公告)日：2006-12-26
申请号：US09219442
申请日：1998-12-23
申请人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
发明人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/52 , C07K2319/00 , C12N2799/026
摘要： Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译： 公开了人VEGF2多肽，生物活性，诊断学或治疗上有用的片段，类似物或衍生物，以及编码这种VEGF2多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。
-
-
-
-
-
-
-
-
-
搜索结果
54 条记录 (耗时 0.034 秒)
