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1.发明申请THERAPEUTIC APPLICATIONS OF P53 ISOFORMS IN REGENERATIVE MEDICINE, AGING AND CANCER 有权P53认证在再生医学，老化和癌症中的应用公开(公告)号：US20110243968A1
公开(公告)日：2011-10-06
申请号：US12742250
申请日：2008-10-21
申请人： Curtis C. Harris , Kaori Fujita , Izumi Horikawa , Borivoj Vojtesek , Jean-Christophe Bourdon , David P. Lane
发明人： Curtis C. Harris , Kaori Fujita , Izumi Horikawa , Borivoj Vojtesek , Jean-Christophe Bourdon , David P. Lane
IPC分类号： A61K31/713 , C12N5/071 , C12N5/09 , A61K31/7088 , C12N15/85 , A61K48/00 , C07H21/02 , A61P43/00 , A61P35/00 , A61P37/06
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K48/00 , C07K14/4746 , C12N5/0652 , C12N15/1135 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/141 , C12N2310/531
摘要： The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
摘要翻译： 本发明提供使用p53肿瘤抑制蛋白的同种型调节细胞衰老和细胞增殖的方法和组合物。 通过调节细胞衰老和增殖，本发明的方法和组合物用于抑制癌细胞生长或产生用于组织再生的细胞群体。
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2.发明授权Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer 有权p53异构体在再生医学，衰老和癌症中的治疗应用公开(公告)号：US08575121B2
公开(公告)日：2013-11-05
申请号：US12742250
申请日：2008-10-21
申请人： Curtis C. Harris , Kaori Fujita , Izumi Horikawa , Borivoj Vojtesek , Jean-Christophe Bourdon , David P. Lane
发明人： Curtis C. Harris , Kaori Fujita , Izumi Horikawa , Borivoj Vojtesek , Jean-Christophe Bourdon , David P. Lane
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K48/00 , C07K14/4746 , C12N5/0652 , C12N15/1135 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/141 , C12N2310/531
摘要： The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
摘要翻译： 本发明提供使用p53肿瘤抑制蛋白的同种型调节细胞衰老和细胞增殖的方法和组合物。 通过调节细胞衰老和增殖，本发明的方法和组合物用于抑制癌细胞生长或产生用于组织再生的细胞群体。
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3.发明授权Substituted 6-(2-aminobenzylamino)purine derivatives, their use as medicaments and preparations containing these compounds 有权取代的6-（2-氨基苄基氨基）嘌呤衍生物，它们用作药物和含有这些化合物的制剂公开(公告)号：US09023857B2
公开(公告)日：2015-05-05
申请号：US13146339
申请日：2010-01-22
申请人： Libor Havlicek , Vladimir Krystof , Marek Zatloukal , Karel Dolezal , Miroslav Strnad , Borivoj Vojtesek
发明人： Libor Havlicek , Vladimir Krystof , Marek Zatloukal , Karel Dolezal , Miroslav Strnad , Borivoj Vojtesek
IPC分类号： A61K31/52 , C07D473/16
CPC分类号： C07D473/16 , A61K31/52
摘要： The invention relates to new substituted 6-(2-aminobenzylamino)purines, represented by the general formula I, which can be used in CDK inhibition, in particular, in the treatment of viral infections and diseases involving cell proliferation. The invention further includes pharmaceutical preparations containing substituted 6-(2-aminobenzylamino)purines.
摘要翻译： 本发明涉及可用于CDK抑制，特别是用于治疗病毒感染和涉及细胞增殖的疾病的由通式I表示的新的取代的6-（2-氨基苄基氨基）嘌呤。 本发明还包括含有取代的6-（2-氨基苄基氨基）嘌呤的药物制剂。
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4.发明申请SUBSTITUTED 6-(2-AMINOBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND PREPARATIONS CONTAINING THESE COMPOUNDS 有权取代的6-（2-氨基苯甲酰胺）嘌呤衍生物，它们作为含有这些化合物的药物和制剂使用公开(公告)号：US20110287111A1
公开(公告)日：2011-11-24
申请号：US13146339
申请日：2010-01-22
申请人： Libor Havlicek , Vladimir Krystof , Marek Zatloukal , Karel Dolezal , Miroslav Strnad , Borivoj Vojtesek
发明人： Libor Havlicek , Vladimir Krystof , Marek Zatloukal , Karel Dolezal , Miroslav Strnad , Borivoj Vojtesek
IPC分类号： A61K31/52 , A61K33/24 , A61K31/704 , A61K31/522 , A61K31/7056 , A61P35/00 , A61P31/16 , A61P31/14 , A61P31/20 , A61P31/22 , A61P31/18 , A61P9/00 , A61P17/06 , A61P29/00 , A61P37/06 , A61P3/10 , A61P25/00 , A61P25/28 , A61P33/00 , A61P33/02 , A61P31/10 , A61P13/12 , A61P17/00 , A61P19/06 , C07D473/16
CPC分类号： C07D473/16 , A61K31/52
摘要： The invention relates to new substituted 6-(2-aminobenzylamino)purines, represented by the general formula I, which can be used in CDK inhibition, in particular, in the treatment of viral infections and diseases involving cell proliferation. The invention further includes pharmaceutical preparations containing substituted 6-(2-aminobenzylamino)purines.
摘要翻译： 本发明涉及可用于CDK抑制，特别是用于治疗病毒感染和涉及细胞增殖的疾病的由通式I表示的新的取代的6-（2-氨基苄基氨基）嘌呤。 本发明还包括含有取代的6-（2-氨基苄基氨基）嘌呤的药物制剂。
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5.发明授权Substitution derivatives of N6-benzyladenosine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds 有权N6-苄基腺苷的取代衍生物，其制备方法，其用于制备药物，化妆品制剂和生长调节剂，药物制剂，化妆品制剂和含有这些化合物的生长调节剂公开(公告)号：US08119614B2
公开(公告)日：2012-02-21
申请号：US10540993
申请日：2003-12-29
申请人： Karel Dolezal , Igor Popa , Marek Zatloukal , René Lenobel , Dana Hradecká , Borivoj Vojtesek , Stjepan Uldrijan , Petr Mlejnek , Stefaan Werbrouck , Miroslav Strnad
发明人： Karel Dolezal , Igor Popa , Marek Zatloukal , René Lenobel , Dana Hradecká , Borivoj Vojtesek , Stjepan Uldrijan , Petr Mlejnek , Stefaan Werbrouck , Miroslav Strnad
IPC分类号： C07H19/167 , C07H19/173 , A01N43/04 , A61K31/70 , A61K8/02
摘要： The invention concerns novel substitution derivatives of N6-benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N6-benzyladenosine derivatives and their use as drugs, cosmetic preparations and growth regulators comprising these derivatives as active compound and use of these derivatives for preparation of pharmaceutical compositions, in biotechnological processes, in cosmetics and in agriculture.
摘要翻译： 本发明涉及对植物，动物和人类细胞具有抗癌，有丝分裂，免疫抑制和抗衰老特性的N6-苄基腺苷的新型取代衍生物。 本发明还涉及这些N6-苄基腺苷衍生物的制备方法及其作为药物，化妆品制剂和包含这些衍生物作为活性化合物的生物调节剂的用途，以及这些衍生物在制备药物组合物中的用途，在生物技术方法中在化妆品中的用途 在农业。
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6.发明申请Substitution derivatives of n6-benzyladenosine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds 有权n6-苄基腺苷的取代衍生物，其制备方法，其用于制备药物，化妆品制剂和生长调节剂，药物制剂，化妆品制剂和含有这些化合物的生长调节剂公开(公告)号：US20060166925A1
公开(公告)日：2006-07-27
申请号：US10540993
申请日：2003-12-29
申请人： Karel Dolezal , Igor Popa , Marek Zatloukal , Rene Lenobel , Dana Hradecka , Borivoj Vojtesek , Stjepan Uldrijan , Petr Mlejnek , Stefaan Werbrouck , Miroslav Strnad
发明人： Karel Dolezal , Igor Popa , Marek Zatloukal , Rene Lenobel , Dana Hradecka , Borivoj Vojtesek , Stjepan Uldrijan , Petr Mlejnek , Stefaan Werbrouck , Miroslav Strnad
IPC分类号： C07H19/16 , A61K31/7076
摘要： The invention concerns novel substitution derivatives of N6-benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N6-benzyladenosine derivatives and their use as drugs, cosmetic preparations and growth regulators comprising these derivatives as active compound and use of these derivatives for preparation of pharmaceutical compositions, in biotechnological processes, in cosmetics and in agriculture.
摘要翻译： 本发明涉及对植物，动物和人类细胞具有抗癌，有丝分裂，免疫抑制和抗衰老特性的N 6 - 苄基腺苷的新型取代衍生物。 本发明还涉及这些N 6 - 苄基腺苷衍生物的制备方法及其作为药物，化妆品制剂和包含这些衍生物作为活性化合物的生长调节剂的用途，以及这些衍生物用于制备药物组合物的用途 ，在生物技术过程中，在化妆品和农业领域。
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