公开(公告)号：US20200246532A1

公开(公告)日：2020-08-06

申请号：US16851305

申请日：2020-04-17

Applicant: CytoSorbents Corporation

Inventor： Thomas D. Golobish ,  Vincent J. Capponi ,  David R. Clay

IPC: A61M1/36 ,  A61M1/34 ,  B01J20/32 ,  B01J20/26 ,  A01N1/02 ,  B01J20/28 ,  A61M1/02

Abstract: The invention concerns methods of removing undesirable molecules from the blood or physiologic fluid; said method comprising contacting said blood or physiologic fluid with a sorbent, said sorbent comprising a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of ligands attached to the surface of said cross-linked polymeric material, comprising (i) zwitterionic moieties, (ii) oligo(ethylene glycol) moieties or (iii) mixtures thereof; said contacting comprising said sorbent sorbing a plurality of said undesirable molecules when said sorbent is administered within a patient's body.

公开(公告)号：US20210402075A1

公开(公告)日：2021-12-30

申请号：US17313424

申请日：2021-05-06

Applicant: CytoSorbents Corporation

Inventor： Thomas D. Golobish ,  Vincent J. Capponi ,  David R. Clay

IPC: A61M1/36 ,  A61M1/34 ,  A61M1/02 ,  B01J20/28 ,  B01J20/32 ,  A01N1/02 ,  B01J20/26

Abstract: The invention concerns methods of removing undesirable molecules from the blood or physiologic fluid; said method comprising contacting said blood or physiologic fluid with a sorbent, said sorbent comprising a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of ligands attached to the surface of said cross-linked polymeric material, comprising (i) zwitterionic moieties, (ii) oligo(ethylene glycol) moieties or (iii) mixtures thereof; said contacting comprising said sorbent sorbing a plurality of said undesirable molecules when said sorbent is administered within a patient's body.

公开(公告)号：US11020521B2

公开(公告)日：2021-06-01

申请号：US16851305

申请日：2020-04-17

Applicant: CytoSorbents Corporation

Inventor： Thomas D. Golobish ,  Vincent J. Capponi ,  David R. Clay

IPC: A61M1/36 ,  A61M1/34 ,  A61M1/02 ,  B01J20/28 ,  B01J20/32 ,  A01N1/02 ,  B01J20/26

Abstract: The invention concerns methods of removing undesirable molecules from the blood or physiologic fluid; said method comprising contacting said blood or physiologic fluid with a sorbent, said sorbent comprising a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of ligands attached to the surface of said cross-linked polymeric material, comprising (i) zwitterionic moieties, (ii) oligo(ethylene glycol) moieties or (iii) mixtures thereof; said contacting comprising said sorbent sorbing a plurality of said undesirable molecules when said sorbent is administered within a patient's body.

公开(公告)号：US11752250B2

公开(公告)日：2023-09-12

申请号：US14230108

申请日：2014-03-31

Applicant: CytoSorbents Corporation

Inventor： Thomas D. Golobish ,  Vincent J. Capponi ,  David R. Clay

IPC: A61M1/36 ,  A61M1/34 ,  A61M1/02 ,  B01J20/28 ,  B01J20/32 ,  A01N1/02 ,  B01J20/26

CPC classification number: A61M1/3679 ,  A01N1/02 ,  A01N1/0215 ,  A61M1/0272 ,  A61M1/34 ,  A61M1/36 ,  B01J20/261 ,  B01J20/267 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28092 ,  B01J20/3208 ,  B01J20/3246 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3272 ,  B01J20/3282 ,  B01J20/3285 ,  B01J2220/62

Abstract: The invention concerns methods of treating blood, blood product, or physiologic fluid to provide at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; said method comprising contacting said blood, blood product or physiologic fluid with a sorbent, said sorbent being primarily in a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of at least one of (1) zwitterionic moieties and (2) oligo(ethylene glycol) moieties attached to the surface of said cross-linked polymeric material.

公开(公告)号：US20140294751A1

公开(公告)日：2014-10-02

申请号：US14230108

申请日：2014-03-31

Applicant: CytoSorbents Corporation

Inventor： Thomas D. Golobish ,  Vincent J. Capponi ,  David R. Clay

IPC: A61M1/36 ,  A61K31/785 ,  A61K31/765 ,  A61M1/34

CPC classification number: A61M1/3679 ,  A01N1/02 ,  A01N1/0215 ,  A61M1/0272 ,  A61M1/34 ,  A61M1/36 ,  B01J20/261 ,  B01J20/267 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28092 ,  B01J20/3208 ,  B01J20/3246 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3272 ,  B01J20/3282 ,  B01J20/3285 ,  B01J2220/62

Abstract: The invention concerns methods of treating blood, blood product, or physiologic fluid to provide at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; said method comprising contacting said blood, blood product or physiologic fluid with a sorbent, said sorbent being primarily in a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of at least one of (1) zwitterionic moieties and (2) oligo(ethylene glycol) moieties attached to the surface of said cross-linked polymeric material.

Abstract translation: 本发明涉及治疗血液，血液制品或生理液的方法，以提供以下至少之一：（i）增加血液，血液制品或生理液体的保质期，（ii）保持新鲜血液，血液制品或生理液体的新鲜度 ，和（iii）从血液，血液制品或生理液中除去不需要的分子; 所述方法包括使所述血液，血液制品或生理液体与吸着剂接触，所述吸附剂主要为多种固体形式，并且包含具有多个（1）两性离子部分中的至少一种的交联聚合物材料和（2） ）低聚（乙二醇）部分连接到所述交联聚合物材料的表面。