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公开(公告)号：US11504428B2
公开(公告)日：2022-11-22
申请号：US16633087
申请日：2017-11-24
Inventor： Xiaojun Peng , Mingle Li , Jiangli Fan , Qichao Yao , Jianjun Du , Saran Long , Jingyun Wang
IPC: A61B5/00 , A61B8/00 , A61B10/00 , A61K41/00 , A61K47/55 , A61K31/405 , C07D421/12 , A61P35/00 , C07D417/12 , C07D293/10 , C07D279/18 , A61K31/4188 , A61K31/5415 , C07D279/36 , A61K31/55 , C07D495/04
Abstract: A photosensitizer and derivative, application thereof. The photosensitizer has the structure of general formula I, wherein X is S or Se, Y is organic or inorganic ion, R1 and R2 are independently selected from H, alkyl, alkoxy, alkyl amido, alkyl azide and the like; R3 is selected from H, alkyl, alkoxy, amino sulfonyl, hydroxyl, carboxyl and the like, and L1 is a linker selected from —(CH2)n1— or —(CH2CH2O)n2—. The derivatives are molecular medicines with drug molecules of anticancer and chemotherapy or tumor targeting function connected to the said photosensitizer. The photosensitizer has excellent near infrared characteristics and low dark toxicity and is used in the field of photodynamic tumor therapy. The introduction of benzophenothiazine or benzophenoselenazine into derivatives with tumor-targeting function could improve the specific uptake of photosensitizer in tumor tissues. Moreover, clinical anticancer drugs can be introduced into the structure of benzophenothiazine or benzophenoselenazine to achieve the purpose of combining therapy of photodynamic therapy and chemotherapy.
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2.发明授权公开(公告)号：US09862731B2
公开(公告)日：2018-01-09
申请号：US15039674
申请日：2014-11-26
Applicant: DALIAN UNIVERSITY OF TECHNOLOGY
Inventor： Jiangli Fan , Hao Zhu , Xiaojun Peng , Jingyun Wang
CPC classification number: C07F5/022 , C07F5/02 , C09K11/06 , C09K2211/1022 , C09K2211/1029 , G01N33/582 , G01N33/84
Abstract: The present invention provides a difluoroboron dipyrromethene fluorescent probe having a structure represented by the following general formula I, and a production method and an application thereof. Said difluoroboron dipyrromethene fluorescent probe exhibits low background fluorescence, and a rapid and significant fluorescence enhancement up to 100 times after the addition of hypochloric acid. The fluorescent intensity of said fluorescent probe shows a good linear relation with the concentration of hypochloric acid in a nanomole level, and the detection limit thereof is 0.56 nanomole. Said fluorescent probe has good selectivity since it hardly responds to other reactive oxygen species such as H2O2, O2−, TBHP, HO., TBO., 1O2 and NO., and is not interfered by pH in a wide range. Said fluorescent probe can be applied to detect hypochloric acid in living cells.
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3.发明授权公开(公告)号：US10029996B2
公开(公告)日：2018-07-24
申请号：US14486210
申请日：2014-09-15
Applicant: DALIAN UNIVERSITY OF TECHNOLOGY
Inventor： Xiaojun Peng , Si Zhang , Jiangli Fan , Jingyun Wang
IPC: C07D417/06 , C07D277/64 , C07D215/10 , G01N1/30
Abstract: The present invention provides a category of cyano-substituted asymmetric cyanine dyes having the following general structural Formula I and its synthesizing method. The cyano-substituted asymmetric cyanine dyes in present invention are easily synthesized and have long emission wavelength, high molar extinction coefficient, high sensitivity, good light stability, high fluorescence quantum yield after binding with nucleic acid, and low cell toxicity, which is beneficial for application as fluorescent dyes and could also be used in the field of identifying nucleic acid molecules, clinical diagnostics, and immunoassay testing etc.
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公开(公告)号：US11639360B2
公开(公告)日：2023-05-02
申请号：US17053042
申请日：2019-04-22
Inventor： Jiangli Fan , Qichao Yao , Haidong Li , Yana Bian , Mingle Li , Jingyun Wang , Xiaojun Peng
IPC: C07D517/16 , A61P35/00 , A61K9/14 , A61K41/00 , C07D513/16 , C09K11/06 , G01N21/64
Abstract: Disclosed are an oxazine compound and an application thereof. The oxazine compound has a structure of a general formula F. The oxazine compound described in the disclosure is a photo/acoustic dynamic active organic molecule with near-infrared absorption-emission function as well as photosensitivity and acoustic sensitivity. Maximum absorption and emission wavelengths of the compound are both greater than 660 nanometers, and a triplet-state conversion rate of the compound is high; and under illumination or ultrasound, the compound can produce reactive oxygen species with high efficiency, which has a good killing effect on cancer cells and cancer tissues, and almost has no toxic or side effects on normal tissues while achieving photo/acoustic dynamic therapy on tumors.
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