公开(公告)号：US20140196630A1

公开(公告)日：2014-07-17

申请号：US14216906

申请日：2014-03-17

Applicant: ZHUHAI NINESTAR MANAGEMENT CO., LTD. ,  DALIAN UNIVERSITY OF TECHNOLOGY

Inventor： Xiaojun Peng ,  Shiyu Li ,  Jinhe Wu ,  Fanming Meng ,  Rong Zhang ,  Jiangli Fan ,  Feng Wang ,  Shaolei Li

IPC: C09B5/14 ,  C09D11/00

CPC classification number: C09B5/14 ,  C09D11/02 ,  C09D11/328

Abstract: The present invention relates to a class of magenta dyes, their preparation methods and applications. The magenta dyes include the compounds which simultaneously contain carboxyl group, sulfonic acid group and the carbonyl propyl sulfurylsulfonic acid on the anthrapyridone skeleton, showing in the form of general formula (I) or their mixtures. In the general formula (I): A may be cation M4, or substituted or unsubstituted benzyl group, or substituted or unsubstituted naphthyl methyl; M1, M2, M3 are respectively cation or cationic groups; Sulfonic acid group (SO3M2)m may located any position of the benzene ring, of which m is an integer of 0-2. As containing carboxyl (or carboxylic benzyl ester or naphthoate), sulfonic acid groups and carbonyl propyl sulfuryl simultaneously, the magenta dyes of the present invention feature outstanding tone, brightness, light resistance, water resistance, ozone resistance as well as solubility and solution stability, etc.

Abstract translation: 本发明涉及一类品红染料及其制备方法和用途。 品红色染料包括在蒽吡啶酮骨架上同时含有羧基，磺酸基和羰基丙基硫代磺酸的化合物，以通式（I）或其混合物的形式显示。 在通式（I）中：A可以是阳离子M4，或取代或未取代的苄基，或取代或未取代的萘基甲基; M1，M2，M3分别为阳离子或阳离子基团; 磺酸基（SO3M2）m可以位于苯环的任何位置，其中m是0-2的整数。 由于含有羧基（或羧酸苄基酯或萘甲酸酯），磺酸基和羰基丙基磺酰基，本发明品红染料具有突出的色调，亮度，耐光性，耐水性，耐臭氧性以及溶解性和溶液稳定性， 等等

公开(公告)号：US09011589B2

公开(公告)日：2015-04-21

申请号：US14216906

申请日：2014-03-17

Applicant: Dalian University of Technology ,  Zhuhai Ninestar Management Co., Ltd.

Inventor： Xiaojun Peng ,  Shiyu Li ,  Jinhe Wu ,  Fanming Meng ,  Rong Zhang ,  Jiangli Fan ,  Feng Wang ,  Shaolei Li

IPC: C09D11/328 ,  C09B5/14 ,  C09D11/02

CPC classification number: C09B5/14 ,  C09D11/02 ,  C09D11/328

Abstract: The present invention relates to a class of magenta dyes, their preparation methods and applications. The magenta dyes include the compounds which simultaneously contain carboxyl group, sulfonic acid group and the carbonyl propyl sulfurylsulfonic acid on the anthrapyridone skeleton, showing in the form of general formula (I) or their mixtures. In the general formula (I): A may be cation M4, or substituted or unsubstituted benzyl group, or substituted or unsubstituted naphthyl methyl; M1, M2, M3 are respectively cation or cationic groups; Sulfonic acid group (SO3M2)m may located any position of the benzene ring, of which m is an integer of 0-2. As containing carboxyl (or carboxylic benzyl ester or naphthoate), sulfonic acid groups and carbonyl propyl sulfuryl simultaneously, the magenta dyes of the present invention feature outstanding tone, brightness, light resistance, water resistance, ozone resistance as well as solubility and solution stability, etc.

Abstract translation: 本发明涉及一类品红染料及其制备方法和用途。 品红色染料包括在蒽吡啶酮骨架上同时含有羧基，磺酸基和羰基丙基硫代磺酸的化合物，以通式（I）或其混合物的形式显示。 在通式（I）中：A可以是阳离子M4，或取代或未取代的苄基，或取代或未取代的萘基甲基; M1，M2，M3分别为阳离子或阳离子基团; 磺酸基（SO3M2）m可以位于苯环的任何位置，其中m是0-2的整数。 由于含有羧基（或羧酸苄基酯或萘甲酸酯），磺酸基和羰基丙基磺酰基，本发明品红染料具有突出的色调，亮度，耐光性，耐水性，耐臭氧性以及溶解性和溶液稳定性， 等等

公开(公告)号：US11639360B2

公开(公告)日：2023-05-02

申请号：US17053042

申请日：2019-04-22

Applicant: DALIAN UNIVERSITY OF TECHNOLOGY ,  DALIAN CHROMAS BIOSCIENCE CO., LTD

Inventor： Jiangli Fan ,  Qichao Yao ,  Haidong Li ,  Yana Bian ,  Mingle Li ,  Jingyun Wang ,  Xiaojun Peng

IPC: C07D517/16 ,  A61P35/00 ,  A61K9/14 ,  A61K41/00 ,  C07D513/16 ,  C09K11/06 ,  G01N21/64

Abstract: Disclosed are an oxazine compound and an application thereof. The oxazine compound has a structure of a general formula F. The oxazine compound described in the disclosure is a photo/acoustic dynamic active organic molecule with near-infrared absorption-emission function as well as photosensitivity and acoustic sensitivity. Maximum absorption and emission wavelengths of the compound are both greater than 660 nanometers, and a triplet-state conversion rate of the compound is high; and under illumination or ultrasound, the compound can produce reactive oxygen species with high efficiency, which has a good killing effect on cancer cells and cancer tissues, and almost has no toxic or side effects on normal tissues while achieving photo/acoustic dynamic therapy on tumors.

公开(公告)号：US08734580B2

公开(公告)日：2014-05-27

申请号：US13919996

申请日：2013-06-17

Applicant: Dalian University of Technology ,  Zhuhai Ninestar Management, Co., Ltd.

Inventor： Xiaojun Peng ,  Jinhe Wu ,  Zhi Long ,  Rong Zhang ,  Licheng Liaoning ,  Feng Wang ,  Shaolei Li ,  Jiangli Fan ,  Fengling Song ,  Shiguo Sun

IPC: C09D11/02 ,  C07D221/18

CPC classification number: C09D11/328 ,  C07D221/18 ,  C09B5/14 ,  C09B67/0034 ,  C09B67/0038 ,  C09D5/028 ,  C09D7/41

Abstract: The present invention relates to compounds shown in the general formula (I) or (III), the salts thereof or their mixtures, as well as their preparation method and application. In the general formula (I), X1 is H or CO2H; X2 is OH or phenyl group with 0-2 sulfonic acid substituents, and the sulfonic acid substituents are located at random positions of a benzene ring; when X2 is OH, X1 is H; when X2 is phenyl group with 0-2 sulfonic acid substituents, X1 is H or CO2H; n is an integer of 0-2; and in the general formula (III), n and m are respectively an integer of 0-2. The compounds and the mixtures not only have improved light resistance, ozone resistance and water resistance, but also have excellent water solubility and long-term stability in ink-jet ink.

Abstract translation: 本发明涉及通式（I）或（III）所示的化合物，其盐或其混合物及其制备方法和应用。 在通式（I）中，X 1为H或CO 2 H; X2是OH或具有0-2个磺酸取代基的苯基，磺酸取代基位于苯环的随机位置; 当X2是OH时，X1是H; 当X2是具有0-2个磺酸取代基的苯基时，X 1是H或CO 2 H; n是0-2的整数; 在通式（III）中，n和m分别为0-2的整数。 化合物和混合物不仅具有改进的耐光性，耐臭氧性和耐水性，而且在喷墨油墨中也具有优异的水溶性和长期稳定性。

公开(公告)号：US11504428B2

公开(公告)日：2022-11-22

申请号：US16633087

申请日：2017-11-24

Applicant: DALIAN UNIVERSITY OF TECHNOLOGY ,  DALIAN CHROMAS BIOSCIENCE CO., LTD

Inventor： Xiaojun Peng ,  Mingle Li ,  Jiangli Fan ,  Qichao Yao ,  Jianjun Du ,  Saran Long ,  Jingyun Wang

IPC: A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K41/00 ,  A61K47/55 ,  A61K31/405 ,  C07D421/12 ,  A61P35/00 ,  C07D417/12 ,  C07D293/10 ,  C07D279/18 ,  A61K31/4188 ,  A61K31/5415 ,  C07D279/36 ,  A61K31/55 ,  C07D495/04

Abstract: A photosensitizer and derivative, application thereof. The photosensitizer has the structure of general formula I, wherein X is S or Se, Y is organic or inorganic ion, R1 and R2 are independently selected from H, alkyl, alkoxy, alkyl amido, alkyl azide and the like; R3 is selected from H, alkyl, alkoxy, amino sulfonyl, hydroxyl, carboxyl and the like, and L1 is a linker selected from —(CH2)n1— or —(CH2CH2O)n2—. The derivatives are molecular medicines with drug molecules of anticancer and chemotherapy or tumor targeting function connected to the said photosensitizer. The photosensitizer has excellent near infrared characteristics and low dark toxicity and is used in the field of photodynamic tumor therapy. The introduction of benzophenothiazine or benzophenoselenazine into derivatives with tumor-targeting function could improve the specific uptake of photosensitizer in tumor tissues. Moreover, clinical anticancer drugs can be introduced into the structure of benzophenothiazine or benzophenoselenazine to achieve the purpose of combining therapy of photodynamic therapy and chemotherapy.

公开(公告)号：US09862731B2

公开(公告)日：2018-01-09

申请号：US15039674

申请日：2014-11-26

Applicant: DALIAN UNIVERSITY OF TECHNOLOGY

Inventor： Jiangli Fan ,  Hao Zhu ,  Xiaojun Peng ,  Jingyun Wang

IPC: C07F5/02 ,  C09K11/06 ,  G01N33/58 ,  G01N33/84

CPC classification number: C07F5/022 ,  C07F5/02 ,  C09K11/06 ,  C09K2211/1022 ,  C09K2211/1029 ,  G01N33/582 ,  G01N33/84

Abstract: The present invention provides a difluoroboron dipyrromethene fluorescent probe having a structure represented by the following general formula I, and a production method and an application thereof. Said difluoroboron dipyrromethene fluorescent probe exhibits low background fluorescence, and a rapid and significant fluorescence enhancement up to 100 times after the addition of hypochloric acid. The fluorescent intensity of said fluorescent probe shows a good linear relation with the concentration of hypochloric acid in a nanomole level, and the detection limit thereof is 0.56 nanomole. Said fluorescent probe has good selectivity since it hardly responds to other reactive oxygen species such as H2O2, O2−, TBHP, HO., TBO., 1O2 and NO., and is not interfered by pH in a wide range. Said fluorescent probe can be applied to detect hypochloric acid in living cells.

公开(公告)号：US10029996B2

公开(公告)日：2018-07-24

申请号：US14486210

申请日：2014-09-15

Applicant: DALIAN UNIVERSITY OF TECHNOLOGY

Inventor： Xiaojun Peng ,  Si Zhang ,  Jiangli Fan ,  Jingyun Wang

IPC: C07D417/06 ,  C07D277/64 ,  C07D215/10 ,  G01N1/30

Abstract: The present invention provides a category of cyano-substituted asymmetric cyanine dyes having the following general structural Formula I and its synthesizing method. The cyano-substituted asymmetric cyanine dyes in present invention are easily synthesized and have long emission wavelength, high molar extinction coefficient, high sensitivity, good light stability, high fluorescence quantum yield after binding with nucleic acid, and low cell toxicity, which is beneficial for application as fluorescent dyes and could also be used in the field of identifying nucleic acid molecules, clinical diagnostics, and immunoassay testing etc.