公开(公告)号：US20250135426A1

公开(公告)日：2025-05-01

申请号：US18564237

申请日：2021-11-30

Applicant: DALIAN UNIVERSITY OF TECHNOLOGY

Inventor： Huanan WANG ,  Zhenzhen DOU ,  Kaiwen CHEN ,  Xin LI ,  Chuanbo GONG ,  Kai SUN

IPC: B01J13/00 ,  B33Y10/00 ,  B33Y50/00 ,  B33Y70/10 ,  B33Y80/00

Abstract: The present invention relates to the field of materials science, the field of nanomaterials, and the field of biomedical engineering, and in particular to an inorganic non-metallic nanoparticle-assembled hydrogel material and an application thereof inl additive manufacturing technology. The hydrogel material is assembled from inorganic non-metallic particles, so as to form a hydrogel network; the size of the inorganic non-metallic particles ranges from 10 nm to 20 um; the inorganic non-metallic particles account for 2-80 wt % of the total mass of hydrogel; and the hydrogel network has microscopic pores having a pore size ranging from 0.1 um to 30 um. The inorganic non-metallic particles are assembled into a hydrogel material by an electrostatic assembly method or a hydrophobic action assembly method or a magnetic action assembly method. The hydrogel material is additively manufactured to obtain a gel scaffold which is used as a bone repair scaffold or a cartilage repair scaffold. The hydrogel material of the present invention is directly applied to inorganic non-metallic additive manufacturing technology, without using an additive or a cross-linking agent.

公开(公告)号：US20240100224A1

公开(公告)日：2024-03-28

申请号：US18263046

申请日：2021-05-19

Applicant: DALIAN UNIVERSITY OF TECHNOLOGY

Inventor： Huanan WANG ,  Kaiwen CHEN

IPC: A61L27/52 ,  A61L24/00 ,  A61L24/10 ,  A61L27/22 ,  A61L27/56 ,  A61L31/04 ,  A61L31/14

CPC classification number: A61L27/52 ,  A61L24/0031 ,  A61L24/0036 ,  A61L24/104 ,  A61L27/222 ,  A61L27/56 ,  A61L31/045 ,  A61L31/145 ,  A61L31/146 ,  A61L2300/424 ,  A61L2400/04 ,  A61L2400/06 ,  A61L2430/02

Abstract: An injectable, moldable and printable gramular hydrogel material crosslinked by non-covalent and covalent bonds, a preparation method therefor, and applications thereof are provided. The material uses gelatin particles or particles that have core-shell structures as basic structural units, and forms a continuous and porous particle network by means of the reversible non-covalent crosslinking and covalent bond crosslinking of the particles. The gelatin particles or the particles that have core-shell structures form a continuous porous particle network by means of reversible self-assembly under the effect of the non-covalent bonds, thus achieving injectable, printable, moldable and self-healing properties. Furthermore, high strength granular hydrogels are formed by means of initiating covalent crosslinking. The material can be used as a drug-sustained release carrier, a tissue engineering scaffold and a tissue adhesive hemostatic material in the field of biomedicine.