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公开(公告)号：US11661567B2
公开(公告)日：2023-05-30
申请号：US16305259
申请日：2017-05-31
Applicant: DANISCO US INC.
Inventor： David Marquez , Michael Stoner , James T. Kellis, Jr. , Adam Garske , Joshua Roy Basler , Katherine Augustyn , Priyanka Chandrasekaran , Miles Christopher Scotcher , Lilia Maria Babe , Richard R. Bott , David A. Estell , Gudrun Vogtentanz , Sina Pricelius , Jian Yao
CPC classification number: C11D3/386 , C12N9/54 , C12N15/52 , C12Y304/21062
Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
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公开(公告)号：US11447762B2
公开(公告)日：2022-09-20
申请号：US16030994
申请日：2018-07-10
Applicant: DANISCO US INC
Inventor： Viktor Yuryevich Alekseyev , Neelam S. Amin , Luis G. Cascao-Pereira , Katherine D. Collier , David A. Estell , James T. Kellis, Jr. , Ayrookaran J. Poulose , Philip F. Souter , Glenn S. Ward , Katherine Augustyn , Jian Yao
Abstract: The present invention provides serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants.
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公开(公告)号：US09096838B2
公开(公告)日：2015-08-04
申请号：US14268488
申请日：2014-05-02
Applicant: Danisco US Inc.
Inventor： Luis G. Cascao-Pereira , David A. Estell , James T. Kellis, Jr.
CPC classification number: C12N9/54 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38663 , C11D3/38681 , C12N15/52 , C12Y304/21062
Abstract: The present invention provides engineered protease variants. In particular, the protease variants comprise combinable mutations at selected surface positions that affect the charge and/or hydrophobicity of the enzyme to enhance at least one desired property of the resulting variant enzyme in a chosen application. Compositions comprising the protease variants, and methods for using the same are also provided.
Abstract translation: 本发明提供工程蛋白酶变体。 特别地，蛋白酶变体在选定的表面位置包含影响酶的电荷和/或疏水性的可组合突变，以在所选择的应用中增强所得变体酶的至少一种所需性质。 还提供了包含蛋白酶变体的组合物及其使用方法。
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公开(公告)号：US20250092336A1
公开(公告)日：2025-03-20
申请号：US18914556
申请日：2024-10-14
Applicant: DANISCO US INC.
Inventor： Joshua Roy Basler , Michael Stoner , James T. Kellis, Jr. , Adam Garske , David Marquez , Katherine Augustyn , Priyanka Chandrasekaran , Miles Christopher Scotcher , Lilia Maria Babe , Richard R. Bott , David A. Estell , Gudrun Vogtentanz , Sina Pricelius , Jian Yao
Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
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公开(公告)号：US10563189B2
公开(公告)日：2020-02-18
申请号：US14537761
申请日：2014-11-10
Applicant: Danisco US Inc.
Inventor： Joshua R. Basler , Luis G. Cascao-Pereira , David A. Estell , James T. Kellis, Jr.
IPC: C12N9/54 , C11D3/386 , C12N9/52 , A23K20/189 , C11D11/00
Abstract: The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using these variants and compositions. In some embodiments, the present invention provides variant subtilisins suitable for laundry cleaning applications.
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Patent Agency Ranking
公开(公告)号：US12203112B2
公开(公告)日：2025-01-21
申请号：US17547287
申请日：2021-12-10
Applicant: DANISCO US INC
Inventor： Ayrookaran J. Poulose , Joshua Roy Basler , Luis G. Cascao-Pereira , James T. Kellis, Jr. , Alexander Pisarchik , Daniel Esteban Torres Pazmino , David A. Estell
Abstract: The present invention provides protease variants comprising three amino acid substitutions selected from X101N, X128S, and X217Q, compositions comprising such protease variants, and methods of using such protease variants and compositions.
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公开(公告)号：US12146122B2
公开(公告)日：2024-11-19
申请号：US18301460
申请日：2023-04-17
Applicant: DANISCO US INC.
Inventor： Joshua Roy Basler , Michael Stoner , James T. Kellis, Jr. , Adam Garske , David Marquez , Katherine Augustyn , Priyanka Chandrasekaran , Miles Christopher Scotcher , Lilia Maria Babe , Richard R. Bott , David A. Estell , Gudrun Vogtentanz , Sina Pricelius , Jian Yao
Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
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公开(公告)号：US20240093124A1
公开(公告)日：2024-03-21
申请号：US18301460
申请日：2023-04-17
Applicant: DANISCO US INC.
Inventor： Joshua Roy Basler , Michael Stoner , James T. Kellis, Jr. , Adam Garske , David Marquez , Katherine Augustyn , Priyanka Chandrasekaran , Miles Christopher Scotcher , Lilia Maria Babe , Richard R. Bott , David A. Estell , Gudrun Vogtentanz , Sina Pricelius , Jian Yao
CPC classification number: C11D3/386 , C12N9/54 , C12N15/52 , C12Y304/21062
Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
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公开(公告)号：US10093887B2
公开(公告)日：2018-10-09
申请号：US14337024
申请日：2014-07-21
Applicant: Danisco US Inc.
Inventor： Wolfgang Aehle , Luis G. Cascao-Pereira , David A. Estell , Frits Goedegebuur , James T. Kellis, Jr. , Ayrookaran J. Poulose , Brian F. Schmidt
Abstract: The present invention provides methods for protein engineering and serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants.
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10.发明授权公开(公告)号：US09157052B2
公开(公告)日：2015-10-13
申请号：US14225292
申请日：2014-03-25
Applicant: Danisco US Inc.
Inventor： Joshua Roy Basler , Luis Gustavo Cascao-Pereira , David A. Estell , James T. Kellis, Jr. , Alexander Pisarchik , Ayrookaran J. Poulose , Daniel Torres-Pazmino
CPC classification number: C12N9/54 , C11D3/386 , C12N9/52 , C12N9/64 , C12Y304/21062
Abstract: The present invention provides protease variants, compositions comprising protease variants, and methods of using such protease variants and compositions.
Abstract translation: 本发明提供了蛋白酶变体，包含蛋白酶变体的组合物，以及使用这种蛋白酶变体和组合物的方法。
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