公开(公告)号：US11384150B2

公开(公告)日：2022-07-12

申请号：US16467655

申请日：2017-12-13

申请人： Development Center for Biotechnology ,  Tunghai University

发明人： Shih-Hsien Chuang ,  Wei-Ting Chao ,  Wei-Ting Sun ,  Hui-Jan Hsu ,  Wun-Huei Lin

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  C07K16/30 ,  A61K38/00 ,  A61K45/06 ,  A61K39/00 ,  A61K39/395

摘要： An immunoconjugate, comprising an anti-EGFR antibody or a binding fragment thereof, and a kinase inhibitor.

公开(公告)号：US20210015942A1

公开(公告)日：2021-01-21

申请号：US16244090

申请日：2019-01-09

申请人： Development Center for Biotechnology

发明人： Shih-Hsien Chuang ,  Chu-Bin Liao ,  Wei-Ting Sun ,  Chen-Hsien Liang ,  Wun-Huei Lin ,  Chun-Liang Lai ,  Her-Sheng Lin

IPC分类号： A61K47/68 ,  C07K16/32 ,  A61P35/00

摘要： An immunoconjugate having the Formula Ab-[L1-(A-L2-B)m]n, wherein: (a) Ab is an antibody or a binding fragment thereof; (b) L1 and L2 are each independently a linker, wherein L1 and L2 are the same or different and wherein L1 links to L2; (c) A is a target-protein ligand/binder; (d) B is a ubiquitin ligase ligand/binder, and (e) n and m are independently integers from 1 to 8. The target protein includes kinase, G protein-coupled receptors, transcription factor, phosphatases, and RAS superfamily members.

公开(公告)号：US12091454B2

公开(公告)日：2024-09-17

申请号：US18089812

申请日：2022-12-28

申请人： DEVELOPMENT CENTER FOR BIOTECHNOLOGY ,  NATIONAL HEALTH RESEARCH INSTITUTES

发明人： Cheng-Chou Yu ,  Shu-Ping Yeh ,  Chao-Yang Huang ,  Szu-Liang Lai ,  Shih-Liang Hsiao ,  Mei-Ling Hou ,  Tzung-Jie Yang ,  Wei-Ting Sun ,  Liang-Yu Hsia ,  Andrew Yueh ,  Chiung-Tong Chen ,  Ren-Huang Wu ,  Pei-Shan Wu ,  Han-Shu Hu ,  Tzu-Chin Wu ,  Jia-Ni Tian

IPC分类号： C07K16/28 ,  A61P35/00 ,  C12N15/63

CPC分类号： C07K16/28 ,  A61P35/00 ,  C12N15/63 ,  C07K2317/24 ,  C07K2317/31

摘要： A humanized anti-neurotensin receptor 1 (NTSR1) antibody or an antigen-binding fragment thereof. Also, a method for treating, prophylactic treating and/or preventing diseases and/or disorders caused by or related to NTSR1 activity and/or signaling, and a method or kit for detecting NTSR1 in a sample.

公开(公告)号：US11998613B2

公开(公告)日：2024-06-04

申请号：US17339747

申请日：2021-06-04

申请人： DEVELOPMENT CENTER FOR BIOTECHNOLOGY

发明人： Shih-Hsien Chuang ,  Wei-Ting Sun ,  Ying-Shuan Lailee ,  Chun-Liang Lai ,  Wun-Huei Lin ,  Win-Yin Wei ,  Shih-Chong Tsai ,  Cheng-Chou Yu ,  Chao-Yang Huang

IPC分类号： A61K47/68 ,  A61K47/54 ,  A61P35/00

CPC分类号： A61K47/6851 ,  A61K47/545 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6889 ,  A61P35/00

摘要： The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.