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公开(公告)号：US20220187259A1
公开(公告)日：2022-06-16
申请号：US17593109
申请日：2020-06-10
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Lyle Lorrence Burton , Stephen Alexander Tate
Abstract: A separation device is instructed to separate a compound from a sample over a time period. A mass spectrometer is instructed to measure a plurality of intensities of at least one ion of the separated compound over the time period, producing a chromatogram. At least one peak of the at least one ion is identified from the chromatogram using a peak-finding algorithm. Two or more different peak integration areas are calculated for the at least one peak by applying the peak-finding algorithm with two or more different values for at least one peak-finding parameter. Two or more plots of the at least one peak that each shows graphically a different peak integration area are displayed on a display device at the same time. In response, data is received from a user selection device that indicates user selection of one of the two or more plots.
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2.发明授权公开(公告)号：US11069517B2
公开(公告)日：2021-07-20
申请号：US16487079
申请日：2018-02-01
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Stephen Alexander Tate
IPC: H01J49/00
Abstract: A system is disclosed for identifying precursor ions originating from an ion source device. A mass filter filters an ion beam by using a series of overlapping precursor ion mass selection windows across the precursor ion mass range. A mass analyzer analyzes the precursor ions of each precursor ion mass selection window of the series, producing a plurality of precursor ion spectra for the precursor ion mass range. A precursor ion is selected from the spectra. The intensities for the selected precursor ion are retrieved from the spectra and a trace is produced that describes how the intensity of the selected precursor ion varies with the location of the precursor ion mass selection window. The selected precursor ion is identified as a precursor ion originating from the ion source device if the trace includes a nonzero intensity for the m/z value of the selected precursor ion.
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Patent Agency Ranking
3.发明申请公开(公告)号：US20200013609A1
公开(公告)日：2020-01-09
申请号：US16487079
申请日：2018-02-01
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Stephen Alexander Tate
Abstract: A system is disclosed for identifying precursor ions originating from an ion source device. A mass filter filters an ion beam by using a series of overlapping precursor ion mass selection windows across the precursor ion mass range. A mass analyzer analyzes the precursor ions of each precursor ion mass selection window of the series, producing a plurality of precursor ion spectra for the precursor ion mass range. A precursor ion is selected from the spectra. The intensities for the selected precursor ion are retrieved from the spectra and a trace is produced that describes how the intensity of the selected precursor ion varies with the location of the precursor ion mass selection window. The selected precursor ion is identified as a precursor ion originating from the ion source device if the trace includes a nonzero intensity for the m/z value of the selected precursor ion.
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公开(公告)号：US12019057B2
公开(公告)日：2024-06-25
申请号：US17593109
申请日：2020-06-10
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Lyle Lorrence Burton , Stephen Alexander Tate
CPC classification number: G01N30/8631 , G01N30/14 , G01N30/7233 , G01N2030/027
Abstract: A separation device is instructed to separate a compound from a sample over a time period. A mass spectrometer is instructed to measure a plurality of intensities of at least one ion of the separated compound over the time period, producing a chromatogram. At least one peak of the at least one ion is identified from the chromatogram using a peak-finding algorithm. Two or more different peak integration areas are calculated for the at least one peak by applying the peak-finding algorithm with two or more different values for at least one peak-finding parameter. Two or more plots of the at least one peak that each shows graphically a different peak integration area are displayed on a display device at the same time. In response, data is received from a user selection device that indicates user selection of one of the two or more plots.
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5.发明申请MASS SPECTROMETRY SYSTEMS AND METHODS FOR IMPROVED MULTIPLE REACTION MONITORING 审中-公开用于改进多重反应监测的质谱系统和方法公开(公告)号：US20140353490A1
公开(公告)日：2014-12-04
申请号：US14369782
申请日：2012-11-28
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Stephen Alexander Tate , Nicholas Bloomfield , Christopher M. Lock
CPC classification number: H01J49/0072 , H01J49/0031 , H01J49/0045 , H01J49/4215
Abstract: The present teachings are directed to methods and apparatuses for mass spectrometry that include configuring mass spectrometry apparatus to perform a plurality of separate assays on ions fragmented from a given analyte, where each such analysis by the spectrometry apparatus is targeted at a different respective associated mass-to-charge ratio and provides a quantitative measure of the number of fragments thereof.
Abstract translation: 本教导涉及用于质谱法的方法和装置，其包括配置质谱装置以对从给定分析物碎裂的离子进行多个单独的测定，其中通过光谱测定装置的每个这样的分析针对不同的相应的质量 - 并提供其片段数量的定量测量。
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公开(公告)号：US09299548B2
公开(公告)日：2016-03-29
申请号：US14353762
申请日：2012-10-26
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Ronald Bonner , Yves Le Blanc , Stephen Alexander Tate
IPC: H01J49/00
CPC classification number: H01J49/0045 , H01J49/0027 , H01J49/0031 , H01J49/004
Abstract: A method is provided for mass spectrometry. The method includes generating precursor ions from a sample; transmitting the precursor ions into a collision cell; generating product ions in the collision cell; detecting the precursor and product ions; applying modulation to one or more of the precursor ion intensity and the product ion intensity; and identifying precursor ion and product ion relationships by analyzing intensity profiles defined by the modulation.
Abstract translation: 提供了用于质谱的方法。 该方法包括从样品中产生前体离子; 将前体离子传输到碰撞池中; 在碰撞池中产生产物离子; 检测前体和产物离子; 对一种或多种前体离子强度和产物离子强度进行调制; 并通过分析由调制定义的强度分布来识别前体离子和产物离子关系。
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公开(公告)号：US20150034815A1
公开(公告)日：2015-02-05
申请号：US14353762
申请日：2012-10-26
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Ronald Bonner , Yves Le Blanc , Stephen Alexander Tate
IPC: H01J49/00
CPC classification number: H01J49/0045 , H01J49/0027 , H01J49/0031 , H01J49/004
Abstract: A method is provided for mass spectrometry. The method includes generating precursor ions from a sample; transmitting the precursor ions into a collision cell; generating product ions in the collision cell; detecting the precursor and product ions; applying modulation to one or more of the precursor ion intensity and the product ion intensity; and identifying precursor ion and product ion relationships by analyzing intensity profiles defined by the modulation.
Abstract translation: 提供了用于质谱的方法。 该方法包括从样品中产生前体离子; 将前体离子传输到碰撞池中; 在碰撞池中产生产物离子; 检测前体和产物离子; 对一种或多种前体离子强度和产物离子强度进行调制; 并通过分析由调制定义的强度分布来识别前体离子和产物离子关系。
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