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公开(公告)号：US09822352B2
公开(公告)日：2017-11-21
申请号：US14397866
申请日：2013-05-03
Applicant: DSM IP ASSETS B.V.
IPC: C12N9/64 , A23C19/032 , A23C19/068 , A23C19/072
CPC classification number: C12N9/6483 , A23C19/032 , A23C19/0326 , A23C19/0684 , A23C19/072 , A23C2220/202 , A23C2250/15 , C12Y304/23004
Abstract: A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295 said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having chymosin activity. Such a variant polypeptide may be used in the preparation of a cheese.
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Patent Agency Ranking
公开(公告)号：US10253305B2
公开(公告)日：2019-04-09
申请号：US15782528
申请日：2017-10-12
Applicant: DSM IP ASSETS B.V.
IPC: C12N9/64 , A23C19/032 , A23C19/068 , A23C19/072
Abstract: A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295 said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having chymosin activity. Such a variant polypeptide may be used in the preparation of a cheese.
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公开(公告)号：US20150118356A1
公开(公告)日：2015-04-30
申请号：US14397866
申请日：2013-05-03
Applicant: DSM IP ASSETS B.V.
IPC: A23C19/032 , C12N9/64
CPC classification number: C12N9/6483 , A23C19/032 , A23C19/0326 , A23C19/0684 , A23C19/072 , A23C2220/202 , A23C2250/15 , C12Y304/23004
Abstract: A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295 said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having chymosin activity. Such a variant polypeptide may be used in the preparation of a cheese.
Abstract translation: 具有凝乳酶活性的变体多肽，其中所述变体具有当与包含SEQ ID NO：2所示的序列的凝乳酶比对时的氨基酸序列包含对应于任何氨基酸的氨基酸残基的至少一个取代 2，22，40，48，50，51，53，61，62，76，88，98，99，109，112，117，125，126，135，144，160，161，163，187， 194,2200,201,202,203,221,223,240,242,244,254,267,271,273,278,280,284,289,292,294或295表示所述位置是参照SEQ ID NO：2，其中与具有凝乳酶活性的参照多肽相比，变体具有一个或多个改变的特性。 这种变体多肽可用于制备奶酪。
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公开(公告)号：US10167463B2
公开(公告)日：2019-01-01
申请号：US14397865
申请日：2013-05-03
Applicant: DSM IP ASSETS B.V.
Inventor： Petrus Jacobus Theodorus Dekker , Rene Marcel De Jong , Michael Dennis Tabeling , Cornelis Marinus Muijlwijk
IPC: C12N9/64 , A23C19/032 , A23C19/068 , A23C19/072
Abstract: The invention relates to a polypeptide having chymosin activity which: a. is capable of hydrolyzing bovine alpha s1-casein at position F23F24 so as to form αs1-I CN (f24-199) more rapidly than camel chymosin; and b. has a C/P ratio higher than the C/P ratio of bovine chymosin.
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公开(公告)号：US20180030427A1
公开(公告)日：2018-02-01
申请号：US15782528
申请日：2017-10-12
Applicant: DSM IP ASSETS B.V.
IPC: C12N9/64 , A23C19/072 , A23C19/032 , A23C19/068
CPC classification number: C12N9/6483 , A23C19/032 , A23C19/0326 , A23C19/0684 , A23C19/072 , A23C2220/202 , A23C2250/15 , C12Y304/23004
Abstract: A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295 said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having chymosin activity. Such a variant polypeptide may be used in the preparation of a cheese.
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公开(公告)号：US20150140169A1
公开(公告)日：2015-05-21
申请号：US14397865
申请日：2013-05-03
Applicant: DSM IP ASSETS B.V.
Inventor： Petrus Jacobus Theodorus Dekker , René Marcel De Jong , Michael Dennis Tabeling , Cornelis Marinus Muijlwijk
IPC: C12N9/64 , A23C19/032
CPC classification number: C12N9/6483 , A23C19/032 , A23C19/0326 , A23C19/0684 , A23C19/072 , A23C2220/202 , A23C2250/15 , C12Y304/23004
Abstract: The invention relates to a polypeptide having chymosin activity which: a. is capable of hydrolysing bovine alpha s1-casein at position F23F24 so as to form αs1-I CN (f24-199) more rapidly than camel chymosin; and b. has a C/P ratio higher than the C/P ratio of bovine chymosin.
Abstract translation: 本发明涉及具有凝乳酶活性的多肽，其具有：a。 能够在F23F24位水解牛α1酪蛋白，从而比骆驼凝乳酶更快地形成αs1-CN（f24-199）; 和b。 C / P比高于牛乳蛋白的C / P比。
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