公开(公告)号：US20220125074A1

公开(公告)日：2022-04-28

申请号：US17291697

申请日：2019-11-08

Applicant: DSM IP Assets B.V. ,  Midori USA, Inc.

Inventor： Estel CANET-MARTINEZ ,  John Michael GEREMIA ,  Ulrich HOELLER ,  Lisa Ann LAPRADE ,  Ghislain SCHYNS

IPC: A23K20/163 ,  A23K50/10 ,  A23K50/30 ,  A23K50/75 ,  A23L33/125 ,  A61K31/702

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating metabolites present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level said metabolites.

公开(公告)号：US20210238539A1

公开(公告)日：2021-08-05

申请号：US17050626

申请日：2019-05-21

Applicant: DSM IP Assets B.V.

Inventor： Christopher Mark FARRELL ,  Lisa Ann LAPRADE ,  Otto Martin LEHMANN ,  Joshua TRUEHEART ,  Bastien Jean Wolfgang CHEVREUX

IPC: C12N1/16 ,  C12N9/90 ,  C12P33/00

Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified yeast strains expressing enzymes having improved C-8 sterol isomerase activity leading to increased ratios of 7-DHC in the sterol mix.

公开(公告)号：US20240293437A1

公开(公告)日：2024-09-05

申请号：US18420540

申请日：2024-01-23

Applicant: DSM IP Assets B.V.

Inventor： Stephane DUVAL ,  John Michael GEREMIA ,  Lisa Ann LAPRADE ,  April WAGUESPACK-LEVY ,  Estefania PEREZ CALVO ,  Ghislain SCHYNS ,  Viviane VERLHAC ,  Joshua Thomas CLAYPOOL

IPC: A61K31/702 ,  A23K20/163 ,  A23K50/30 ,  A23K50/75

CPC classification number: A61K31/702 ,  A23K20/163 ,  A23K50/30 ,  A23K50/75

Abstract: Methods of feeding animals are disclosed wherein providing feed additives are provided that modulate the gut microbiome to improve the health, nutrition, and growth performance. Methods of modulating the microbial species present in the gastrointestinal tract of an animal are also disclosed. Such modulation includes, for example, modulating the level or function of microbial species.

公开(公告)号：US20210393658A1

公开(公告)日：2021-12-23

申请号：US17292132

申请日：2019-11-08

Applicant: DSM IP Assets B.V. ,  Midori USA, Inc.

Inventor： Stephane DUVAL ,  John Michael GEREMIA ,  Lisa Ann LAPRADE ,  April Waguespack LEVY ,  Estefania PEREZ CALVO ,  Ghislain SCHYNS ,  Viviane VERLHAC ,  Joshua CLAYPOOL

IPC: A61K31/702 ,  A23K20/163 ,  A23K50/75 ,  A23K50/30

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating the microbial species present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level or function of microbial species.

公开(公告)号：US20210395284A1

公开(公告)日：2021-12-23

申请号：US17292119

申请日：2019-11-08

Applicant: DSM IP Assets B.V. ,  Midori USA, Inc. ,  KALEIDO BIOSCIENCES, INC.

Inventor： Manuela BAUR ,  Estel CANET-MARTINEZ ,  Ruediger HAINZ ,  Ulrich HOELLER ,  Lisa Ann LAPRADE ,  John Michael GEREMIA ,  Ghislain SCHYNS

IPC: C07H1/00 ,  C07H3/06

Abstract: The present disclosure relates oligosaccharide preparations suitable for use in nutritional compositions such as animal feed and methods of manufacturing the described oligosaccharide preparations. The present disclosure further relates to nutritional compositions that comprise the oligosaccharide preparations. The disclosed oligosaccharide preparations can be advantageous as an animal feed due to, at least in part, their prebiotic utility and the presence of anhydro-subunit containing oligosaccharides, which can be used to detect and/or determine the presence and content of the disclosed oligosaccharide preparations in the nutritional composition.

公开(公告)号：US20210222222A1

公开(公告)日：2021-07-22

申请号：US17051610

申请日：2019-05-21

Applicant: DSM IP ASSETS B.V.

Inventor： Christopher Mark FARRELL ,  Lisa Ann LAPRADE ,  Otto Martin LEHMANN ,  Joshua TRUEHEART ,  Bastien Jean Wolfgang CHEVREUX

IPC: C12P33/02 ,  C12N9/02 ,  C12N1/16

Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified host strains expressing enzymes having improved C-5 sterol 5 desaturase activity and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.

公开(公告)号：US20210115412A1

公开(公告)日：2021-04-22

申请号：US17050603

申请日：2019-05-21

Applicant: DSM IP ASSETS B.V.

Inventor： Christopher Mark FARRELL ,  Lisa Ann LAPRADE ,  Otto Martin LEHMANN ,  Joshua TRUEHEART

IPC: C12N9/10 ,  C12P33/00

Abstract: The present invention is related to modified sterol acyltransferase enzymes with improved activity and/or specificity towards acylation of the vitamin D3 precursor 7-dehydrocholesterol (7-DHC) to be used in biotechnological production of vitamin D3. The invention further relates to a yeast strain expressing said modified enzymes and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.