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1.发明公开公开(公告)号：US20230270920A1
公开(公告)日：2023-08-31
申请号：US18108038
申请日：2023-02-10
Applicant: DSM IP Assets B.V.
Inventor： Noel L. DAVISON , Henricus Johannes ARTS , Aylvin Jorge Angelo Athanasius DIAS , Anne Marie PERSSON , Ruud Jozef Regina Wilhelmus PETERS
IPC: A61L31/08 , A61L17/04 , A61L17/14 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04
CPC classification number: A61L31/086 , A61L17/04 , A61L17/145 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04 , A61L2420/02 , A61L2430/02 , A61L2430/38
Abstract: The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 μm in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.
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公开(公告)号：US20250032674A1
公开(公告)日：2025-01-30
申请号：US18718647
申请日：2022-12-12
Applicant: DSM IP ASSETS B.V.
Inventor： Mark Kenneth HAZZARD , Noel L. DAVISON , Mandy Maria Jozefina WIERMANS , Nicolaes Hubertus Maria DE BONT , Loes Heleen PLUYMEN
Abstract: Disclosed herein are composite sheets and prosthetic medical devices formed therefrom. In an embodiment, a composite sheet has a thickness of 25-250 μm and comprises 10-70 mass %, based on the total mass of the composite sheet, of a knit fabric having thickness of 15-225 μm and comprising strands of 2-50 dtex, the strands comprising biocompatible polymer fibers, the strands comprising biocompatible polymer fibers, wherein the fabric comprises a thickness in a plurality of first locations, and pores in a plurality of second locations; and 30-90 mass %, based on the total mass of the composite sheet, of a polyurethane coating, wherein the polyurethane coating coats the fabric and fills the pores of the fabric such that the composite sheet is substantially impermeable to water.
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公开(公告)号：US20220031915A1
公开(公告)日：2022-02-03
申请号：US17432698
申请日：2020-02-27
Applicant: DSM IP Assets B.V.
Abstract: Disclosed are medical components, formulations for making medical components, methods of forming medical components, and methods of making medical devices from the medical components. The medical components possess radiopacity. In an embodiment, a medical component comprises from 5 to 50 wt % of a polyurethane and from 50 to 95 wt % of a radiopacifier, based on the total weight of the medical component, wherein the medical component has a thickness of from 0.025 to 1 mm.
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4.发明申请公开(公告)号：US20250065013A1
公开(公告)日：2025-02-27
申请号：US18946674
申请日：2024-11-13
Applicant: DSM IP Assets B.V.
Abstract: Methods of making a composite fabric for use in or as a medical implant component are disclosed whereby the method includes the steps of providing a textile comprising at least one strand having titer of 2-250 dtex and comprising fibers made from a biocompatible and biostable synthetic polymer; determining locations on the textile where a cut is to be made for an intended use of the textile; optionally pretreating the textile at least at the determined locations on at least one side of the textile with a high-energy source to activate the surface; solution coating the textile at least at a determined location with a coating composition comprising a biocompatible and biostable polyurethane elastomer and a solvent for the polyurethane; removing the solvent from the coated textile; and laser cutting the coated textile as obtained at least a one coated location with an ultra-short pulse laser; to result in a composite biotextile wherein polyurethane is present in an amount of 2.5-90 mass % based on composite biotextile and polyurethane is present at least at a laser-cut edge.
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Patent Agency Ranking
5.发明公开公开(公告)号：US20230310718A1
公开(公告)日：2023-10-05
申请号：US18023801
申请日：2021-08-30
Applicant: DSM IP Assets B.V.
Inventor： Noel L. DAVISON , Mandy Maria Jozefina WIERMANS , Nicolaes Hubertus Maria DE BONT , Mark Kenneth HAZZARD
CPC classification number: A61L31/06 , C08L75/04 , A61L31/14 , C08L2201/06 , C08L2203/02 , C08L2203/16 , A61L2400/18
Abstract: Disclosed herein is a polyurethane composite sheet comprising o a biocompatible and biostable polyurethane elastomer comprising polysiloxane segments, the polyurethane forming a continuous matrix of the sheet; and o a woven or braided fabric having a thickness of 15-150 μm and comprising biocompatible, high-strength polymer fibers; wherein the composite sheet comprises 10-90 mass % of polyurethane, has a thickness of 25-250 μm and an areal density of 5-300 g/m2; and wherein the composite sheet has, in at least one direction, non-linear uniaxial tensile behavior characterized by a 1%-secant modulus of 20-200 MPa, a hardening transition point at 10-45%, and a tensile strength of at least 25 MPa (measured in water at 37° C.).
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6.发明申请公开(公告)号：US20220072199A1
公开(公告)日：2022-03-10
申请号：US17430736
申请日：2020-03-02
Applicant: DSM IP Assets B.V.
Abstract: Disclosed herein is a method of making a composite fabric for use in or as a medical implant component, the method comprising steps of providing a textile comprising at least one strand having titer of 2-250 dtex and comprising fibers made from a biocompatible and biostable synthetic polymer; determining locations on the textile where a cut is to be made for an intended use of the textile; optionally pretreating the textile at least at the determined locations on at least one side of the textile with a high-energy source to activate the surface; solution coating the textile at least at a determined location with a coating composition comprising a biocompatible and biostable polyurethane elastomer and a solvent for the polyurethane; removing the solvent from the coated textile; and laser cutting the coated textile as obtained at least a one coated location with an ultra-short pulse laser; to result in a composite biotextile wherein polyurethane is present in an amount of 2.5-90 mass % based on composite biotextile and polyurethane is present at least at a laser-cut edge. Such composite biotextile as made shows an advantageous combination of good biocompatibility, especially hemocompatibility, high strength and pliability, and has well-defined regular edges that have high suture retention strength. Further embodiments concern the use of such composite biotextile in or as medical implant component for an implantable medical device; such as in orthopedic applications and cardiovascular implants. Other embodiments include such medical devices or implants comprising said composite biotextile or medical implant component.
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公开(公告)号：US20220023501A1
公开(公告)日：2022-01-27
申请号：US17430734
申请日：2020-03-02
Applicant: DSM IP Assets B.V.
Abstract: Disclosed herein is a medical implant component comprising a composite biotextile, which biotextile comprises i) a polyolefin fibrous construct comprising at least one strand with titer of 2-250 dtex, tensile strength of at least 10 cN/dtex and comprising high molar mass polyolefin fibers and ii) a coating comprising a biocompatible and biostable polyurethane elastomer comprising a polysiloxane segment and/or having one or more hydrophobic endgroups, wherein the polyurethane coating is present on at least part of the surface of the biotextile and in an amount of 2.5-90 mass % based on composite biotextile. Such composite biotextile, like a partly coated woven fabric, shows an advantageous combination of good biocompatibility, especially hemocompatibility, high strength and pliability, and laser cuttability; allowing to make pieces of fabric having well-defined regular edges that have high suture retention strength. The invention also provides a method of making said composite biotextile. Further embodiments concern the use of such biotextile in or as medical implant component for an implantable medical device and the use of such medical implant component in making an implantable medical device; such as in orthopedic applications and cardiovascular implants. Other embodiments include such medical devices or implants comprising said medical implant component.
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公开(公告)号：US20250032679A1
公开(公告)日：2025-01-30
申请号：US18918858
申请日：2024-10-17
Applicant: DSM IP Assets B.V.
Inventor： Noel L. DAVISON , Henricus Johannes ARTS , Aylvin Jorge Angelo Athanasius DIAS , Anne Marie PERSSON , Ruud Jozef Regina Wilhelmus PETERS
IPC: A61L31/08 , A61L17/04 , A61L17/14 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04
Abstract: The disclosure relates to a method of making a bioactive coating on a fibrous article for use in a medical implant and implants comprising non-biodegradable fibers, a coating polymer layer formed from a non-biodegradable coating polymer on at least a portion of the fibers, and a bioactive coating disposed on at least a portion of the polymer coating layer. In an embodiment, a method of forming a medical implant results in bioactive ceramic particles being partly embedded in the coating polymer layer.
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公开(公告)号：US20210299332A1
公开(公告)日：2021-09-30
申请号：US16976123
申请日：2019-03-06
Applicant: DSM IP Assets B.V.
Inventor： Aylvin Jorge Angelo Athanasius DIAS , Noel L. DAVISON , Anne Marie PERSSON , Ynze MENGERINK , Paul Mathieu DE BUEGER
Abstract: The disclosure relates to high-strength polyolefin composite fibers, which fibers have a fiber body comprising a composition consisting of polyolefin; 1-30 mass % of bioceramic particles having particle size D50 of 0.01-10 μm; at most 0.05 mass % of residual spin solvent; optionally 0-3 mass % of other additives; and wherein the sum of a)-d) is 100 mass %; and which fibers have bioceramic particles exposed at their surface, and show bioactivity. The composite fibers based on a composition of polyolefin with bioceramic particles mixed therein show particles being exposed at the fiber surface by techniques like AFM and XPS, and although apparently only a relatively small amount of bioceramic particles is exposed at the fiber surface, this appears sufficient for effective interaction with their environment and stimulating a positive biological response as demonstrated by in vitro cell studies.
The present disclosure also concerns a method of making the high-strength composite fibers via a gel spinning process, fibrous articles comprising said bioactive composite fibers. Further embodiments concern use of these fibrous articles as a component of a medical implant or as a medical implant, especially as permanent high-strength orthopedic implants for repairing bone fractures or torn ligaments or tendons. Other embodiments include medical devices or implants comprising said fibrous articles.
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