公开(公告)号：US20250114459A1

公开(公告)日：2025-04-10

申请号：US18984821

申请日：2024-12-17

Applicant: DSM IP Assets B.V.

Inventor： Jennifer AL-RASHID ,  Jacob RIFFEY ,  John Andrew ZUPANCICH

IPC: A61L31/06 ,  A61L29/06 ,  C08G18/12 ,  C08G18/32 ,  C08G18/44 ,  C08G18/48

Abstract: In an embodiment, a polyurethane comprises the residues of i. an aliphatic diisocyanate, ii. an aliphatic diol comprising a poly(ethylene oxide) moiety, iii. an aliphatic diol comprising a polycarbonate moiety, and iv. a chain extender, wherein the polyurethane has a melting temperature of 140° C. or less and has a weight average molecular weight of from 100,000 to 500,000 g/mol. In an embodiment, the polyurethane is substantially devoid of catalyst. In an embodiment, the polyurethane is formed by reactive extrusion. In an embodiment, a medical device comprises the polyurethane and a bioactive agent. The medical devices, methods, and polyurethanes may exhibit benefits in end-product biostability, drug release profile, health and safety, and processing speed or reproducibility.

公开(公告)号：US20150328374A1

公开(公告)日：2015-11-19

申请号：US14653137

申请日：2013-12-20

Applicant: DSM IP ASSETS B.V.

Inventor： George MIHOV ,  John Andrew ZUPANCICH

IPC: A61L31/10 ,  C09D177/12 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61L29/06 ,  A61L29/148 ,  A61L29/16 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  C08G69/44 ,  C08L77/12 ,  C09D177/12 ,  C08L77/00

Abstract: The invention relates to a coating comprising a biodegradable polymer comprising at least two different functional groups pendant to the polymer backbone, which functional groups are selected from the group of carboxyl-, amine, hydroxyl, ester, amide-, thiol- or thioester groups. The two different functional groups comprise at least an unprotected hydrophilic functional group chosen from a carboxyl-, amine, thiol or hydroxyl group and at least a protected hydrophobic functional group chosen from an ester, amide- or thioester group. The invention further relates to an implantable device comprising the coating composition. The implantable device is includes cardiac pacemakers and defibrillators; leads and electrodes for the preceding, organ stimulators such as nerve, bladder, sphincter and diaphragm stimulators, prostheses, rods, vascular grafts, self-expandable stents, balloon-expandable stents, stent-grafts, grafts, catheters, artificial heart valves and cerebrospinal fluid shunts.

Abstract translation: 本发明涉及一种包含可生物降解聚合物的涂层，其包含至少两个垂直于聚合物主链的不同官能团，该官能团选自羧基，胺，羟基，酯，酰胺 - ，硫醇或硫酯基团。 两个不同的官能团包含至少一个选自羧基，胺，硫醇或羟基的未保护的亲水官能团和至少一个选自酯，酰胺或硫酯基团的被保护的疏水官能团。 本发明还涉及包含该涂料组合物的可植入装置。 可植入装置包括心脏起搏器和除颤器; 前列腺的器官刺激器，例如神经，膀胱，括约肌和隔膜刺激器，假体，杆，血管移植物，自扩张支架，球囊扩张支架，支架移植物，移植物，导管，人造心脏瓣膜和脑脊液 流体分流器。

公开(公告)号：US20220054638A1

公开(公告)日：2022-02-24

申请号：US17275729

申请日：2019-09-16

Applicant: DSM IP ASSETS B.V.

Inventor： Jennifer AL-RASHID ,  Jacob RIFFEY ,  John Andrew ZUPANCICH

IPC: A61K47/34 ,  C08G18/12 ,  C08G18/44 ,  C08G18/48 ,  C08G18/40 ,  C08G18/73 ,  C08G18/75

Abstract: In an embodiment, a polyurethane comprises the residues of i. an aliphatic diisocyanate, ii. an aliphatic diol comprising a poly(ethylene oxide) moiety, iii. an aliphatic diol comprising a polycarbonate moiety, and iv. a chain extender, wherein the polyurethane has a melting temperature of 140° C. or less and has a weight average molecular weight of from 100,000 to 500,000 g/mol. In an embodiment, the polyurethane is substantially devoid of catalyst. In an embodiment, the polyurethane is formed by reactive extrusion. In an embodiment, a medical device comprises the polyurethane and a bioactive agent. The medical devices, methods, and polyurethanes may exhibit benefits in end-product biostability, drug release profile, health and safety, and processing speed or reproducibility.

公开(公告)号：US20210147610A1

公开(公告)日：2021-05-20

申请号：US16621571

申请日：2018-06-18

Applicant: DSM IP Assets B.V.

Inventor： Jennifer AL-RASHID ,  John Andrew ZUPANCICH ,  Jayme PAULLIN ,  Jacob RIFFEY ,  Justin KONTRA

IPC: C08G18/75 ,  C08G18/73 ,  C08G18/66 ,  C08G18/61 ,  C08G18/48 ,  C08G18/38 ,  C08G18/32 ,  C08G18/24 ,  C08G18/10 ,  G02B1/04

Abstract: Disclosed herein are compositions and kits of materials for forming a component of a rigid gas permeable lens. An exemplary composition comprises a hydroxyl terminated polyurethane pre-polymer having an average of more than one hydroxyl group per molecule comprising: i) the residue of an aliphatic diisocyanate, a block of comprising polysiloxane and a block comprising hydrophobic poly(alkylene oxide), or ii) the residue of an aliphatic diisocyanate, a block comprising fluoroalkyl or fluoroalkyl ether, and a block of comprising hydrophobic poly(alkylene oxide). The composition further comprises a free aliphatic diisocyanate and a monomeric polyol, or a propoxylate thereof. The average number of hydroxyl groups of the hydroxyl terminated pre-polymer plus the average number of hydroxyl groups of the monomeric polyol, or a propoxylate thereof is equal to from 4.5 to 5.5. Kits of materials comprising elements that when combined form the composition are also disclosed. Further disclosed are articles and ocular devices comprising components formed from the compositions or kits.

公开(公告)号：US20160075841A1

公开(公告)日：2016-03-17

申请号：US14949853

申请日：2015-11-23

Applicant: DSM IP ASSETS B.V.

Inventor： John Andrew ZUPANCICH ,  Paul WYMAN

IPC: C08J7/12 ,  C08J7/02 ,  B05D3/00 ,  C08J7/04

CPC classification number: C08J7/12 ,  B05D3/002 ,  C08J7/02 ,  C08J7/047 ,  C08J2383/04 ,  C09D183/04

Abstract: A method for activating silicone rubber surfaces comprising steps of: i) swelling at least the surface of the silicone rubber matrix with a silicone rubber swelling solvent; ii) treating the silicone rubber matrix during or after the swelling with a solution comprising at least a reactive silane, the reactive silane comprising: a) at least one Si—C bond and; b) at least one hydrolytically labile bond linked to at least one of the Si atoms present in the reactive silane and; c) at least one functional group F1 connected via a Si—C bond to the same or an other Si atom present in the reactive silane, the functional group comprising electrophilic and/or nucleophilic moieties, and/or at least one functional group F2 connected via a Si—C bond to the same or an other Si atom present in the reactive silane comprising moieties which become electrophilic or nucleophilic moieties by a mechanism selected from the group consisting of ring opening of a cyclic structure, hydrolysis, displacement or by a migration reaction; iii) drying and/or heat treating of the treated silicone rubber matrix.

Abstract translation: 一种活化硅橡胶表面的方法，包括以下步骤：i）用硅橡胶溶胀溶剂至少使硅橡胶基体的表面膨胀; ii）在溶胀期间或之后用含至少一种反应性硅烷的溶液处理该硅橡胶基质，该反应性硅烷包含：a）至少一个Si-C键;和 b）与反应性硅烷中存在的至少一种Si原子连接的至少一个水解不稳定键; c）至少一个通过Si-C键连接到存在于反应性硅烷中的相同或另一个Si原子的官能团，所述官能团包括亲电子和/或亲核部分，和/或至少一个官能团F2连接 通过Si-C键与存在于反应性硅烷中的相同或另一个Si原子，其包含通过选自环状结构的开环，水解，置换或通过迁移的机制而成为亲电子部分或亲核部分 反应; iii）处理的硅橡胶基体的干燥和/或热处理。