公开(公告)号：US20250114459A1

公开(公告)日：2025-04-10

申请号：US18984821

申请日：2024-12-17

Applicant: DSM IP Assets B.V.

Inventor： Jennifer AL-RASHID ,  Jacob RIFFEY ,  John Andrew ZUPANCICH

IPC: A61L31/06 ,  A61L29/06 ,  C08G18/12 ,  C08G18/32 ,  C08G18/44 ,  C08G18/48

Abstract: In an embodiment, a polyurethane comprises the residues of i. an aliphatic diisocyanate, ii. an aliphatic diol comprising a poly(ethylene oxide) moiety, iii. an aliphatic diol comprising a polycarbonate moiety, and iv. a chain extender, wherein the polyurethane has a melting temperature of 140° C. or less and has a weight average molecular weight of from 100,000 to 500,000 g/mol. In an embodiment, the polyurethane is substantially devoid of catalyst. In an embodiment, the polyurethane is formed by reactive extrusion. In an embodiment, a medical device comprises the polyurethane and a bioactive agent. The medical devices, methods, and polyurethanes may exhibit benefits in end-product biostability, drug release profile, health and safety, and processing speed or reproducibility.

公开(公告)号：US20240026152A1

公开(公告)日：2024-01-25

申请号：US18127892

申请日：2023-03-29

Applicant: DSM IP Assets B.V.

Inventor： Jennifer AL-RASHID ,  Jacob RIFFEY ,  Chad SUGIYAMA ,  John ZUPANCICH

IPC: C08L75/08 ,  A61B5/145 ,  A61B5/1473 ,  B01D67/00 ,  B01D69/02 ,  B01D71/54 ,  B01D71/58 ,  C08G18/24 ,  C08G18/28 ,  C08G18/48 ,  C08G18/66 ,  C08G18/73 ,  C08G18/75 ,  C08J5/18 ,  C12Q1/00

CPC classification number: C08L75/08 ,  A61B5/14532 ,  A61B5/14735 ,  B01D67/0011 ,  B01D67/0095 ,  B01D69/02 ,  B01D71/54 ,  B01D71/58 ,  C08G18/244 ,  C08G18/2825 ,  C08G18/283 ,  C08G18/4808 ,  C08G18/4833 ,  C08G18/4854 ,  C08G18/6674 ,  C08G18/73 ,  C08G18/755 ,  C08G18/758 ,  C08J5/18 ,  C12Q1/00 ,  A61B5/14546 ,  B01D2323/12 ,  B01D2325/34 ,  B01D2325/36 ,  C08J2375/08 ,  C08J2475/04 ,  C08L2203/16 ,  C08L2205/025

Abstract: Disclosed are compositions that may be useful for forming synthetic membranes, methods of forming membranes therefrom, and membranes. In an embodiment, a membrane comprises a free hydrophilic polymer comprising a polyoxazoline, and a polyurethane, the polyurethane comprising a backbone comprising the reaction product of a diisocyanate, a polymeric aliphatic 5 diol, and optionally a chain extender.

公开(公告)号：US20210147610A1

公开(公告)日：2021-05-20

申请号：US16621571

申请日：2018-06-18

Applicant: DSM IP Assets B.V.

Inventor： Jennifer AL-RASHID ,  John Andrew ZUPANCICH ,  Jayme PAULLIN ,  Jacob RIFFEY ,  Justin KONTRA

IPC: C08G18/75 ,  C08G18/73 ,  C08G18/66 ,  C08G18/61 ,  C08G18/48 ,  C08G18/38 ,  C08G18/32 ,  C08G18/24 ,  C08G18/10 ,  G02B1/04

Abstract: Disclosed herein are compositions and kits of materials for forming a component of a rigid gas permeable lens. An exemplary composition comprises a hydroxyl terminated polyurethane pre-polymer having an average of more than one hydroxyl group per molecule comprising: i) the residue of an aliphatic diisocyanate, a block of comprising polysiloxane and a block comprising hydrophobic poly(alkylene oxide), or ii) the residue of an aliphatic diisocyanate, a block comprising fluoroalkyl or fluoroalkyl ether, and a block of comprising hydrophobic poly(alkylene oxide). The composition further comprises a free aliphatic diisocyanate and a monomeric polyol, or a propoxylate thereof. The average number of hydroxyl groups of the hydroxyl terminated pre-polymer plus the average number of hydroxyl groups of the monomeric polyol, or a propoxylate thereof is equal to from 4.5 to 5.5. Kits of materials comprising elements that when combined form the composition are also disclosed. Further disclosed are articles and ocular devices comprising components formed from the compositions or kits.

公开(公告)号：US20220054638A1

公开(公告)日：2022-02-24

申请号：US17275729

申请日：2019-09-16

Applicant: DSM IP ASSETS B.V.

Inventor： Jennifer AL-RASHID ,  Jacob RIFFEY ,  John Andrew ZUPANCICH

IPC: A61K47/34 ,  C08G18/12 ,  C08G18/44 ,  C08G18/48 ,  C08G18/40 ,  C08G18/73 ,  C08G18/75

Abstract: In an embodiment, a polyurethane comprises the residues of i. an aliphatic diisocyanate, ii. an aliphatic diol comprising a poly(ethylene oxide) moiety, iii. an aliphatic diol comprising a polycarbonate moiety, and iv. a chain extender, wherein the polyurethane has a melting temperature of 140° C. or less and has a weight average molecular weight of from 100,000 to 500,000 g/mol. In an embodiment, the polyurethane is substantially devoid of catalyst. In an embodiment, the polyurethane is formed by reactive extrusion. In an embodiment, a medical device comprises the polyurethane and a bioactive agent. The medical devices, methods, and polyurethanes may exhibit benefits in end-product biostability, drug release profile, health and safety, and processing speed or reproducibility.

公开(公告)号：US20210070989A1

公开(公告)日：2021-03-11

申请号：US16642053

申请日：2018-08-28

Applicant: DSM IP ASSETS B.V.

Inventor： Jennifer AL-RASHID ,  Jacob RIFFEY ,  Chad SUGIYAMA ,  John ZUPANCICH

IPC: C08L75/08 ,  C12Q1/00 ,  B01D71/54 ,  B01D71/58 ,  B01D67/00 ,  B01D69/02

Abstract: Disclosed are compositions that may be useful for forming synthetic membranes, methods of forming membranes therefrom, and membranes. In an embodiment, a membrane comprises a free hydrophilic polymer comprising a polyoxazoline, and a polyurethane, the polyurethane comprising a backbone comprising the reaction product of a diisocyanate, a polymeric aliphatic 5 diol, and optionally a chain extender.