公开(公告)号：US20240217941A1

公开(公告)日：2024-07-04

申请号：US18557241

申请日：2022-04-26

Applicant: DSM IP Assets B.V.

Inventor： Werner BONRATH ,  Rolf KUENZI ,  Meltem TIRPANCI ,  Thomas NETSCHER

IPC: C07D311/72 ,  C07D311/92

CPC classification number: C07D311/72 ,  C07D311/92

Abstract: The present invention relates to the formation of compound of the formula (I) by a ring closure reaction of the compound of the formula (II) in the presence of a catalytic amounts of a base. It has been found that this reaction is very efficient and offers for example an efficient pathway for the synthesis of 3,4-dehydro-α-tocotrienol respectively α-tocotrienol and α-tocopherol.

公开(公告)号：US20250059118A1

公开(公告)日：2025-02-20

申请号：US18720259

申请日：2022-12-15

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Rolf KUENZI ,  Belen NIETO-ORTEGA ,  Jonathan Alan MEDLOCK

IPC: C07C29/42

Abstract: The present invention relates to an improved process for ethynylating specific α,β-unsaturated ketones for producing tertiary acetylenic alcohols.

公开(公告)号：US20240209132A1

公开(公告)日：2024-06-27

申请号：US18556213

申请日：2022-04-26

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Rolf KUENZI ,  Thomas NETSCHER

IPC: C08F232/06 ,  C08F2/06 ,  C08F4/32 ,  C08F4/44

CPC classification number: C08F232/06 ,  C08F2/06 ,  C08F4/32 ,  C08F4/44

Abstract: The present invention relates to the formation of compound of the formula (I) by reacting 2,3,6-trimethylhydroquinone or a protected derivative thereof with the unsaturated alcohol of formula (IIIa) or (IIIb) in the presence of Gd(OTf)3 or Tm(OTf)3 or Al(OTf)3 or Y(OTf)3 or Fe(OTf)2 or camphorsulfonic acid or BiCl3 as acidic catalyst.

公开(公告)号：US20220024960A1

公开(公告)日：2022-01-27

申请号：US17414029

申请日：2019-12-17

Applicant: DSM IP Assets B.V.

Inventor： Werner BONRATH ,  Rolf KUENZI

IPC: C07H3/02 ,  C07H1/00 ,  B01J31/02

Abstract: The present invention relates to an improved process to produce a specific and very efficient epoxidation-catalyst (1,2:4,5-Di-O-isopropylidene-β-D-erythro-2,3-hexodiulo-2,6-pyranose).

公开(公告)号：US20240228454A1

公开(公告)日：2024-07-11

申请号：US18557648

申请日：2022-04-26

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Rolf KUENZI

IPC: C07D311/72 ,  C07D311/92

CPC classification number: C07D311/72 ,  C07D311/92

Abstract: The present invention relates to the formation of compound of the formula (I) by a ring closure reaction of the compound of the formula (II) in the presence of a base in a two-phase system. It has been found that this reaction is very efficient and offers for example an efficient pathway for the synthesis of 3,4-dehydro-α-tocotrienol respectively a-tocotrienol and a-tocopherol.

公开(公告)号：US20230159429A1

公开(公告)日：2023-05-25

申请号：US17801681

申请日：2021-02-16

Applicant: DSM IP Assets B.V.

Inventor： Werner BONRATH ,  Rolf KUENZI

IPC: C07C67/293

CPC classification number: C07C67/293

Abstract: The present invention relates to a new process of production of menaquinone 4, which is also known as vitamin K2.