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公开(公告)号：US20160312246A1
公开(公告)日：2016-10-27
申请号：US15154199
申请日：2016-05-13
Applicant: DSM IP ASSETS B.V.
Inventor： Jacobus Thomas PRONK , Antonius Jeroen Adriaan VAN MARIS , Victor Gabriel GUADALUPE MEDINA
CPC classification number: C12N15/815 , C12N1/18 , C12N9/0006 , C12N9/0008 , C12N9/93 , C12P7/06 , C12P7/10 , C12Y101/01001 , C12Y101/01008 , C12Y102/0101 , C12Y602/01001 , Y02E50/16 , Y02E50/17 , Y02P20/52
Abstract: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising one or more heterologous nucleic acid sequences encoding an NAD+-dependent acetylating acetaldehyde dehydrogenase (EC 1.2.1.10) activity. The invention further relates to the use of a cell according to the invention in the preparation of ethanol.
Abstract translation: 本发明涉及酵母细胞，特别是重组酵母细胞，NADH依赖性甘油合成所需的缺乏酶活性的细胞或相对于NADH依赖性甘油合成具有降低的酶活性的细胞与其相应的 野生型酵母细胞，该细胞包含编码NAD +依赖性乙酰化乙醛脱氢酶（EC 1.2.1.10）活性的一种或多种异源核酸序列。 本发明还涉及根据本发明的细胞在制备乙醇中的用途。
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公开(公告)号：US20210230614A1
公开(公告)日：2021-07-29
申请号：US17176073
申请日：2021-02-15
Applicant: DSM IP Assets B.V.
Inventor： Jacobus Thomas PRONK , Antonius Jeroen Adriaan VAN MARIS , Victor Gabriel GUADALUPE MEDINA
Abstract: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising one or more heterologous nucleic acid sequences encoding an NAD+-dependent acetylating acetaldehyde dehydrogenase (EC 1.2.1.10) activity. The invention further relates to the use of a cell according to the invention in the preparation of ethanol.
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公开(公告)号：US20190127745A1
公开(公告)日：2019-05-02
申请号：US15970641
申请日：2018-05-03
Applicant: DSM IP Assets B.V.
Inventor： Jacobus Thomas PRONK , Antonius Jeroen Adriaan VAN MARIS , Victor Gabriel GUADALUPE MEDINA
Abstract: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising one or more heterologous nucleic acid sequences encoding an NAD+-dependent acetylating acetaldehyde dehydrogenase (EC 1.2.1.10) activity. The invention further relates to the use of a cell according to the invention in the preparation of ethanol.
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Patent Agency Ranking
公开(公告)号：US20210147859A1
公开(公告)日：2021-05-20
申请号：US17108027
申请日：2020-12-01
Applicant: DSM IP ASSETS B.V.
Inventor： Antonius Jeroen Adriaan VAN MARIS , Jacobus Thomas PRONK , Victor Gabriel GUADALUPE MEDINA , Hendrik Wouter WISSELINK
Abstract: The invention relates to a recombinant yeast cell, in particular a transgenic yeast cell, functionally expressing one or more recombinant, in particular heterologous, nucleic acid sequences encoding ribulose-1,5-biphosphate carboxylase oxygenase (Rubisco) and phosphoribulokinase (PRK). The invention further relates to the use of carbon dioxide as an electron acceptor in a recombinant chemotrophic micro-organism, in particular a eukaryotic micro-organism.
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公开(公告)号：US20200299704A1
公开(公告)日：2020-09-24
申请号：US16893065
申请日：2020-06-04
Applicant: DSM IP Assets B.V.
Inventor： Jacobus Thomas PRONK , Antonius Jeroen Adriaan VAN MARIS , Victor Gabriel GUADALUPE MEDINA
Abstract: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising one or more heterologous nucleic acid sequences encoding an NAD+-dependent acetylating acetaldehyde dehydrogenase (EC 1.2.1.10) activity. The invention further relates to the use of a cell according to the invention in the preparation of ethanol.
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公开(公告)号：US20220135989A1
公开(公告)日：2022-05-05
申请号：US17531218
申请日：2021-11-19
Applicant: DSM IP Assets B.V.
Inventor： Jacobus Thomas PRONK , Antonius Jeroen Adriaan VAN MARIS , Victor Gabriel GUADALUPE MEDINA
Abstract: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising one or more heterologous nucleic acid sequences encoding an NAD+-dependent acetylating acetaldehyde dehydrogenase (EC 1.2.1.10) activity. The invention further relates to the use of a cell according to the invention in the preparation of ethanol.
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公开(公告)号：US20210230613A1
公开(公告)日：2021-07-29
申请号：US17176040
申请日：2021-02-15
Applicant: DSM IP Assets B.V.
Inventor： Jacobus Thomas PRONK , Antonius Jeroen Adriaan VAN MARIS , Victor Gabriel GUADALUPE MEDINA
Abstract: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising one or more heterologous nucleic acid sequences encoding an NAD+-dependent acetylating acetaldehyde dehydrogenase (EC 1.2.1.10) activity. The invention further relates to the use of a cell according to the invention in the preparation of ethanol.
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公开(公告)号：US20200248194A1
公开(公告)日：2020-08-06
申请号：US16833342
申请日：2020-03-27
Applicant: DSM IP Assets B.V.
Inventor： Jacobus Thomas PRONK , Antonius Jeroen Adriaan VAN MARIS , Victor Gabriel GUADALUPE MEDINA
Abstract: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising one or more heterologous nucleic acid sequences encoding an NAD+-dependent acetylating acetaldehyde dehydrogenase (EC 1.2.1.10) activity. The invention further relates to the use of a cell according to the invention in the preparation of ethanol.
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