公开(公告)号：US20240409504A1

公开(公告)日：2024-12-12

申请号：US18812888

申请日：2024-08-22

Applicant: Duke University

Inventor： Dennis J. Thiele ,  Bushu Dong ,  Alexander M. Jaeger ,  Philip F. Hughes ,  Timothy Haystead ,  Jiyong Hong

IPC: C07C275/30 ,  A61P35/00 ,  C07C211/40 ,  C07C255/60 ,  C07C275/28 ,  C07C275/34 ,  C07C275/40 ,  C07C275/42 ,  C07C279/18 ,  C07C279/28 ,  C07C281/06 ,  C07C311/46 ,  C07C317/36 ,  C07C317/42 ,  C07D213/40 ,  C07D213/75 ,  C07D223/04 ,  C07D229/02 ,  C07D231/56 ,  C07D233/64 ,  C07D241/24 ,  C07D249/14 ,  C07D271/12 ,  C07D285/10 ,  C07D317/66 ,  C07D333/20 ,  C07D333/36 ,  C07D333/72 ,  C07D405/04 ,  C07D405/12 ,  C07D417/12

Abstract: This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.

公开(公告)号：US12098117B2

公开(公告)日：2024-09-24

申请号：US17312858

申请日：2019-12-11

Applicant: DUKE UNIVERSITY

Inventor： Dennis J. Thiele ,  Bushu Dong ,  Alexander M. Jaeger ,  Philip F. Hughes ,  Timothy Haystead ,  Jiyong Hong

IPC: C07C275/30 ,  A61P35/00 ,  C07C211/40 ,  C07C255/60 ,  C07C275/28 ,  C07C275/34 ,  C07C275/40 ,  C07C275/42 ,  C07C279/18 ,  C07C279/28 ,  C07C281/06 ,  C07C311/46 ,  C07C317/36 ,  C07C317/42 ,  C07D213/40 ,  C07D213/75 ,  C07D223/04 ,  C07D229/02 ,  C07D231/56 ,  C07D233/64 ,  C07D241/24 ,  C07D249/14 ,  C07D271/12 ,  C07D285/10 ,  C07D317/66 ,  C07D333/20 ,  C07D333/36 ,  C07D333/72 ,  C07D405/04 ,  C07D405/12 ,  C07D417/12

CPC classification number: C07C275/30 ,  A61P35/00 ,  C07C211/40 ,  C07C255/60 ,  C07C275/28 ,  C07C275/34 ,  C07C275/40 ,  C07C275/42 ,  C07C279/18 ,  C07C279/28 ,  C07C281/06 ,  C07C311/46 ,  C07C317/36 ,  C07C317/42 ,  C07D213/40 ,  C07D213/75 ,  C07D223/04 ,  C07D229/02 ,  C07D231/56 ,  C07D233/64 ,  C07D241/24 ,  C07D249/14 ,  C07D271/12 ,  C07D285/10 ,  C07D317/66 ,  C07D333/20 ,  C07D333/36 ,  C07D333/72 ,  C07D405/04 ,  C07D405/12 ,  C07D417/12

Abstract: This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.

公开(公告)号：US20220106265A1

公开(公告)日：2022-04-07

申请号：US17312858

申请日：2019-12-11

Applicant: DUKE UNIVERSITY

Inventor： Dennis J. Thiele ,  Bushu Dong ,  Alexander M. Jaeger ,  Philip F. Hughes ,  Timothy Haystead ,  Jiyong Hong

IPC: C07C275/30 ,  A61P35/00 ,  C07D271/12 ,  C07D233/64 ,  C07C275/34 ,  C07D285/10 ,  C07C311/46 ,  C07D231/56 ,  C07D317/66 ,  C07D333/72 ,  C07D229/02 ,  C07C225/20 ,  C07D213/40 ,  C07D213/75 ,  C07D333/20 ,  C07D417/12 ,  C07C279/18 ,  C07C281/06 ,  C07D241/24 ,  C07D405/12 ,  C07D249/14 ,  C07D333/36 ,  C07D405/04 ,  C07D223/04 ,  C07C317/36

Abstract: This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.