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    COMPOSITIONS AND METHODS FOR ADJUVANT CANCER THERAPEUTICS
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR ADJUVANT CANCER THERAPEUTICS 有权

    公开(公告)号：US20220008408A1

    公开(公告)日：2022-01-13

    申请号：US17283461

    申请日：2019-10-09

    Applicant: DUKE UNIVERSITY

    Inventor： Pei Zhou ,  Jiyong Hong

    IPC: A61K31/4706 ,  A61K33/243

    Abstract: This invention relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to translesion synthesis (TLS) pathway. More particularly, this disclosure relates to small molecule inhibitors of TLS, methods of inhibiting TLS pathway with these compounds, and methods of treating diseases related to the TLS pathway.

    LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME
    6.
    发明公开
    LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME 审中-公开

    公开(公告)号：US20240124400A1

    公开(公告)日：2024-04-18

    申请号：US17768152

    申请日：2020-10-12

    Applicant: DUKE UNIVERSITY

    Inventor： Pei Zhou ,  Jiyong Hong

    IPC: C07D209/30 ,  C07C311/20 ,  C07H11/04

    CPC classification number: C07D209/30 ,  C07C311/20 ,  C07H11/04

    Abstract: LpxH targeting compounds, compositions thereof, as well as methods for for making and using the same are disclosed herein. The LpxH target compounds typically have a structure pursuant to Formula (I) and/or a salt thereof, wherein Rb is selected from a single bond, C4 to C10 unsubstituted aryl, C4 to C10 substituted aryl, unsubstituted or substituted four to ten member heterocycle ring, C1 to C10 unsubstituted alkyl, and C1 to C10 substituted alkyl; Rc comprises hydrogen, halogen, —OH, —CO2CH3, —COOH, —CN2CF3, —CF3, —C2OH, —CONHOH, —CCOH, C4 to C10 unsubstituted aryl, C4 to C10 substituted aryl, unsubstituted or substituted four to ten member heterocycle ring, C1 to C10 unsubstituted alkyl, or C1 to C10 substituted alkyl; and Rd and Re are independently hydrogen, —OH, —COH, —COH, —COC, —COOH, Rf, or are taken together as an unsubstituted or substituted four to eight member nitrogen containing heterocycle ring.

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