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公开(公告)号：US20090215724A1
公开(公告)日：2009-08-27
申请号：US12378869
申请日：2009-02-20
申请人： Daisy Joe DuBois , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Yan Lou , Timothy D. Owens , Calvin Wesley Yee
发明人： Daisy Joe DuBois , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Yan Lou , Timothy D. Owens , Calvin Wesley Yee
IPC分类号： A61K31/695 , C07D265/36 , A61K31/536 , C07D487/00 , A61K31/498 , C07F7/02 , C07F5/02 , A61K31/69 , A61P29/00 , A61P37/06 , A61P35/00
CPC分类号： C07D519/00 , C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q1 and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量Q1和R如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号：US07939531B2
公开(公告)日：2011-05-10
申请号：US12378978
申请日：2009-02-20
申请人： Joe Timothy Bamberg , Mark Bartlett , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , Jaehyeon Park , David Bernard Smith , Michael Soth , Hanbiao Yang , Calvin Wesley Yee
发明人： Joe Timothy Bamberg , Mark Bartlett , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , Jaehyeon Park , David Bernard Smith , Michael Soth , Hanbiao Yang , Calvin Wesley Yee
IPC分类号： A61K31/495
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量Q和R如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号：US07932254B2
公开(公告)日：2011-04-26
申请号：US12378869
申请日：2009-02-20
申请人： Daisy Joe DuBois , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Yan Lou , Timothy D. Owens , Calvin Wesley Yee
发明人： Daisy Joe DuBois , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Yan Lou , Timothy D. Owens , Calvin Wesley Yee
IPC分类号： A61K31/495
CPC分类号： C07D519/00 , C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q1 and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量Q1和R如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号：US20090215750A1
公开(公告)日：2009-08-27
申请号：US12378978
申请日：2009-02-20
申请人： Joe Timothy Bamberg , Mark Bartlett , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , Jaehyeon Park , David Bernard Smith , Michael Soth , Hanbiao Yang , Calvin Wesley Yee
发明人： Joe Timothy Bamberg , Mark Bartlett , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , Jaehyeon Park , David Bernard Smith , Michael Soth , Hanbiao Yang , Calvin Wesley Yee
IPC分类号： A61K31/4985 , C07D487/04 , A61P29/00 , A61K31/541 , A61K31/5377 , A61K31/55
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
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公开(公告)号：US08119636B2
公开(公告)日：2012-02-21
申请号：US12378837
申请日：2009-02-20
申请人： Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Yan Lou , Timothy D. Owens , David Bernard Smith
发明人： Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Yan Lou , Timothy D. Owens , David Bernard Smith
IPC分类号： A61K31/495
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量Q和R如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号：US20100267666A1
公开(公告)日：2010-10-21
申请号：US12378977
申请日：2009-02-20
申请人： Joe Timothy Bamberg , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Alam Jahangir , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , David Bernard Smith , Michael Soth , Hanbiao Yang
发明人： Joe Timothy Bamberg , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Alam Jahangir , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , David Bernard Smith , Michael Soth , Hanbiao Yang
IPC分类号： A61K31/4985 , C07D487/04 , A61P35/00 , A61P37/00 , A61P37/06 , A61P29/00 , A61P25/28 , A61P17/06 , A61P3/10 , A61P11/06 , A61P1/04 , A61P35/02 , A61K31/5377 , A61K31/541 , A61K31/397 , A61K31/695
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q1, R, and X are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量Q1，R和X如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号：US08008298B2
公开(公告)日：2011-08-30
申请号：US12378977
申请日：2009-02-20
申请人： Joe Timothy Bamberg , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Alam Jahangir , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , David Bernard Smith , Michael Soth , Hanbiao Yang
发明人： Joe Timothy Bamberg , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Alam Jahangir , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , David Bernard Smith , Michael Soth , Hanbiao Yang
IPC分类号： A61K31/495
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q1, R, and X are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量Q1，R和X如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号：US20090215785A1
公开(公告)日：2009-08-27
申请号：US12378837
申请日：2009-02-20
申请人： Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Raman K. Kondru , Yan Lou , Timothy D. Owens , David Bernard Smith
发明人： Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Raman K. Kondru , Yan Lou , Timothy D. Owens , David Bernard Smith
IPC分类号： A61K31/4985 , C07D487/04 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量Q和R如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号：US07902197B2
公开(公告)日：2011-03-08
申请号：US12378971
申请日：2009-02-20
申请人： Todd Richard Elworthy , Robert Than Hendricks , Rama K. Kondru , Yan Lou , Timothy D. Owens , Michael Soth , Hanbiao Yang
发明人： Todd Richard Elworthy , Robert Than Hendricks , Rama K. Kondru , Yan Lou , Timothy D. Owens , Michael Soth , Hanbiao Yang
IPC分类号： A61K31/495
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
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公开(公告)号：US20090215788A1
公开(公告)日：2009-08-27
申请号：US12378971
申请日：2009-02-20
申请人： Todd Richard Elworthy , Robert Than Hendricks , Rama K. Kondru , Yan Lou , Timothy D. Owens , Michael Soth , Hanbiao Yang
发明人： Todd Richard Elworthy , Robert Than Hendricks , Rama K. Kondru , Yan Lou , Timothy D. Owens , Michael Soth , Hanbiao Yang
IPC分类号： A61K31/4985 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
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