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1.发明申请公开(公告)号：US20080014194A1
公开(公告)日：2008-01-17
申请号：US11697646
申请日：2007-04-06
申请人： Dale Schenk , Kcote Games , Manuel Buttini , Tamie Chilcote , Edward Rockenstein , Eliezar Masliah
发明人： Dale Schenk , Kcote Games , Manuel Buttini , Tamie Chilcote , Edward Rockenstein , Eliezar Masliah
IPC分类号： A61K39/395 , A61P25/00 , C07K16/18 , C12N5/06
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/34
摘要： The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
摘要翻译： 本发明提供用于治疗与突触核蛋白病相关疾病（包括患者脑中的α-突触核蛋白的路易体）的改进剂和方法。 这种方法需要对路易体诱导有益的免疫原性应答的给药剂。 该方法对帕金森病的预防和治疗特别有用。
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公开(公告)号：US20060058233A1
公开(公告)日：2006-03-16
申请号：US11185907
申请日：2005-07-19
申请人： Dale Schenk , Eliezer Masliah , Manuel Buttini , Tamie Chilcote , Edward Rockenstein , Kate Games
发明人： Dale Schenk , Eliezer Masliah , Manuel Buttini , Tamie Chilcote , Edward Rockenstein , Kate Games
IPC分类号： A61K38/17
CPC分类号： C07K16/18 , A61K38/1709 , A61K39/00 , A61K2039/505 , A61P25/16 , A61P25/28
摘要： The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
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公开(公告)号：US07910333B2
公开(公告)日：2011-03-22
申请号：US12695085
申请日：2010-01-27
申请人： Tamie Chilcote , Robin Barbour
发明人： Tamie Chilcote , Robin Barbour
CPC分类号： C07K16/18 , G01N33/6896 , Y10S530/809
摘要： The invention provides methods for detecting alpha-synuclein. The invention also identifies preferred epitopes of alpha synuclein for use in such detection, and provides antibodies specifically binding to such epitopes.
摘要翻译： 本发明提供了检测α-突触核蛋白的方法。 本发明还鉴定用于这种检测的α突触核蛋白的优选表位，并提供与这些表位特异性结合的抗体。
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公开(公告)号：US20060259986A1
公开(公告)日：2006-11-16
申请号：US11194115
申请日：2005-07-29
申请人： Tamie Chilcote , Jason Goldstein , John Anderson , Donald Walker
发明人： Tamie Chilcote , Jason Goldstein , John Anderson , Donald Walker
IPC分类号： A01K67/033 , A01K67/027 , C12Q1/68 , G01N33/53 , A61K38/17
CPC分类号： C07K16/18 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2227/706 , A01K2267/0356 , A61K38/00 , C07K2317/33 , C07K2317/34 , C12N15/8509 , C12Q1/6883 , C12Q2600/156 , G01N33/6896 , G01N2800/28 , G01N2800/2814 , G01N2800/2821 , G01N2800/2835
摘要： The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.
摘要翻译： 该应用鉴定了路易体病（LBD）患者和其转基因动物模型中的α-突触核蛋白的新片段。 这些疾病的特征在于α-突触核蛋白的聚集。 片段相对于全长α-突触核蛋白具有截短的C-末端。 一些片段的特征在于分子量约12kDa，通过SDS胶体电泳在三氯缓冲液中测定，并从天然α-突触核蛋白的C末端截断至少十个相邻的氨基酸。 切割位点优选在残基117之后和天然α-突触核蛋白的残基126之前发生。 这些新型α-突触核蛋白片段的鉴定在药物发现，诊断，治疗和转基因动物中有许多应用。
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公开(公告)号：US20050198694A1
公开(公告)日：2005-09-08
申请号：US10969335
申请日：2004-10-19
申请人： Tamie Chilcote , Jason Goldstein , John Anderson
发明人： Tamie Chilcote , Jason Goldstein , John Anderson
IPC分类号： A01K67/00 , A01K67/027 , A01K67/033 , A01N43/04 , A61K20060101 , A61K31/70 , A61K39/395 , C07K1/00 , C07K14/00 , C07K14/47 , C07K17/00 , C12N15/10 , C12Q1/68 , G01N33/00
CPC分类号： A01K67/027 , C07K14/47 , C12N15/10 , C12N15/1096 , C12Q1/68
摘要： The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to fill-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.
摘要翻译： 该应用鉴定了路易体病（LBD）患者和其转基因动物模型中的α-突触核蛋白的新片段。 这些疾病的特征在于α-突触核蛋白的聚集。 片段相对于填充长度的α-突触核蛋白具有截短的C-末端。 一些片段的特征在于分子量约12kDa，通过SDS胶体电泳在三氯缓冲液中测定，并从天然α-突触核蛋白的C末端截断至少十个相邻的氨基酸。 切割位点优选在残基117之后和天然α-突触核蛋白的残基126之前发生。 这些新型α-突触核蛋白片段的鉴定在药物发现，诊断，治疗和转基因动物中有许多应用。
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公开(公告)号：US08673593B2
公开(公告)日：2014-03-18
申请号：US13051592
申请日：2011-03-18
申请人： Tamie Chilcote , Robin Barbour
发明人： Tamie Chilcote , Robin Barbour
CPC分类号： C07K16/18 , G01N33/6896 , Y10S530/809
摘要： The invention provides methods for detecting alpha-synuclein. The invention also identifies preferred epitopes of alpha synuclein for use in such detection, and provides antibodies specifically binding to such epitopes.
摘要翻译： 本发明提供了检测α-突触核蛋白的方法。 本发明还鉴定用于这种检测的α突触核蛋白的优选表位，并提供与这些表位特异性结合的抗体。
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公开(公告)号：US20100203631A1
公开(公告)日：2010-08-12
申请号：US12695085
申请日：2010-01-27
申请人： Tamie Chilcote , Robin Barbour
发明人： Tamie Chilcote , Robin Barbour
CPC分类号： C07K16/18 , G01N33/6896 , Y10S530/809
摘要： The invention provides methods for detecting alpha-synuclein. The invention also identifies preferred epitopes of alpha synuclein for use in such detection, and provides antibodies specifically binding to such epitopes.
摘要翻译： 本发明提供了检测α-突触核蛋白的方法。 本发明还鉴定用于这种检测的α突触核蛋白的优选表位，并提供与这些表位特异性结合的抗体。
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8.发明授权公开(公告)号：US07674599B2
公开(公告)日：2010-03-09
申请号：US10984192
申请日：2004-11-08
申请人： Tamie Chilcote , Robin Barbour
发明人： Tamie Chilcote , Robin Barbour
IPC分类号： G01N33/543 , G01N33/577
CPC分类号： C07K16/18 , G01N33/6896 , Y10S530/809
摘要： The invention provides methods for detecting alpha-synuclein. The invention also identifies preferred epitopes of alpha synuclein for use in such detection, and provides antibodies specifically binding to such epitopes.
摘要翻译： 本发明提供了检测α-突触核蛋白的方法。 本发明还鉴定用于这种检测的α突触核蛋白的优选表位，并提供与这些表位特异性结合的抗体。
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公开(公告)号：US20080038276A1
公开(公告)日：2008-02-14
申请号：US11830539
申请日：2007-07-30
申请人： Sukanto Sinha , Tamie Chilcote
发明人： Sukanto Sinha , Tamie Chilcote
IPC分类号： A61K39/395 , A61K31/165 , A61K31/341 , A61K31/381 , A61P1/00 , A61P9/00 , C07D207/30 , C07D231/10 , C07D307/87 , C07D401/00 , C07D333/72 , C07D333/22 , C07D307/34 , C07D209/42 , C07C233/57 , A61P3/00 , A61K31/40 , A61K31/415 , A61K31/44
CPC分类号： C07D207/34 , C07D209/42 , C07D231/14 , C07D249/04 , C07D307/68 , C07D333/38 , C07D333/68 , C07D401/06
摘要： The present invention provides compounds that inhibit the activity of plasma kallikrein (PK) and methods of preventing and treating the formation of thrombin during or after a PK dependent disease or condition, for example, after fibrinolysis treatment.
摘要翻译： 本发明提供抑制血浆激肽释放酶（PK）的活性的化合物以及在PK依赖性疾病或病症例如纤维蛋白溶解处理之后或之后预防和治疗凝血酶形成的方法。
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公开(公告)号：US20050196818A1
公开(公告)日：2005-09-08
申请号：US10984192
申请日：2004-11-08
申请人： Tamie Chilcote , Robin Barbour
发明人： Tamie Chilcote , Robin Barbour
IPC分类号： C07K16/18 , G01N20060101 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/68
CPC分类号： C07K16/18 , G01N33/6896 , Y10S530/809
摘要： The invention provides methods for detecting alpha-synuclein. The invention also identifies preferred epitopes of alpha synuclein for use in such detection, and provides antibodies specifically binding to such epitopes.
摘要翻译： 本发明提供了检测α-突触核蛋白的方法。 本发明还鉴定用于这种检测的α突触核蛋白的优选表位，并提供与这些表位特异性结合的抗体。
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