公开(公告)号：US08527064B2

公开(公告)日：2013-09-03

申请号：US12327601

申请日：2008-12-03

申请人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

发明人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

IPC分类号： A61N1/36

CPC分类号： A61N1/0587 ,  A61B5/4035 ,  A61B5/6862 ,  A61B5/6876 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/37288

摘要： Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.

摘要翻译： 各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。 神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。 锚结构被配置为长期且牢固地植入神经刺激器，电源和至少一个电极在肺动脉内。 锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。 在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

公开(公告)号：US20090228078A1

公开(公告)日：2009-09-10

申请号：US12327601

申请日：2008-12-03

申请人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

发明人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

IPC分类号： A61N1/36

CPC分类号： A61N1/0587 ,  A61B5/4035 ,  A61B5/6862 ,  A61B5/6876 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/37288

摘要： Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.

摘要翻译： 各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。 神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。 锚结构被配置为长期且牢固地植入神经刺激器，电源和至少一个电极在肺动脉内。 锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。 在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

公开(公告)号：US20100056931A1

公开(公告)日：2010-03-04

申请号：US12543227

申请日：2009-08-18

申请人： Leah Soffer ,  Haresh G. Sachanandani ,  Bin Mi ,  Yunlong Zhang

发明人： Leah Soffer ,  Haresh G. Sachanandani ,  Bin Mi ,  Yunlong Zhang

IPC分类号： A61B5/0215 ,  A61B5/029

CPC分类号： A61B5/029 ,  A61B5/0002 ,  A61B5/02028 ,  A61B5/02116 ,  A61B5/0215

摘要： A system and method sense a pressure signal in a pulmonary artery and compute a stroke volume and cardiac output. A pressure signal is received from an implantable pressure sensor disposed in a pulmonary artery. The pressure signal includes a systolic period and a diastolic period for determining a heart rate (HR) and a heart cycle. An iteratively-updating model can relate pressure signal and HR to a stroke volume (SV) and a cardiac output (CO). The model extracts a mean pulse pressure (MPP) from the PAP signal and receives a patient-specific vascular resistance model parameter and a patient-specific arterial compliance model parameter. CO can be calculated using the HR, the PAP signal, and the model. The vascular resistance model parameter and the arterial compliance model parameter are iteratively updated using the output of the model.

摘要翻译： 系统和方法检测肺动脉中的压力信号并计算出行程体积和心输出量。 从设置在肺动脉中的可植入压力传感器接收压力信号。 压力信号包括用于确定心率（HR）和心脏周期的收缩期和舒张期。 迭代更新模型可以将压力信号和HR相关联到行程体积（SV）和心输出量（CO）。 该模型从PAP信号中提取平均脉压（MPP），并接收患者特异性血管阻力模型参数和患者特异性动脉顺应性模型参数。 CO可以使用HR，PAP信号和模型来计算。 使用模型的输出迭代地更新血管阻力模型参数和动脉顺应性模型参数。

公开(公告)号：US20090149719A1

公开(公告)日：2009-06-11

申请号：US12257296

申请日：2008-10-23

申请人： Ramesh Wariar ,  Yunlong Zhang ,  Haresh G. Sachanandani

发明人： Ramesh Wariar ,  Yunlong Zhang ,  Haresh G. Sachanandani

IPC分类号： A61B5/00

CPC分类号： A61B5/0002 ,  A61B5/022 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0531 ,  A61B5/091 ,  A61B5/7275 ,  A61B5/7475 ,  G06F19/3418 ,  G16H10/20

摘要： A system and method for integrating qualitative assessment into remote patient management through a visual analog scale is provided. A query is associated to a physiological condition. A visual analog scale includes a linear gradient and, at each end, descriptors for a range of subjective and continuous responses to the query. Assessment data for a patient is obtained. A medical device of the patient is interrogated and stored data is received. The query is displayed with the visual analog scale. An answer to the query includes a point selected between the ends of and along the linear gradient. A distance of the point from one end of the linear gradient is determined. The distance is quantified as a fixed value in proportion to the distance. A risk to the patient is assessed. The stored data and the fixed value are analyzed against the physiological condition to represent patient wellness.

摘要翻译： 提供了一种通过视觉模拟量表将定性评估整合到远程患者管理中的系统和方法。 查询与生理条件相关联。 视觉模拟量表包括线性梯度，并且在每一端都有一系列对查询的主观和连续响应的描述符。 获得患者的评估数据。 询问患者的医疗装置并接收存储的数据。 查询以视觉模拟量表显示。 查询的答案包括在线性渐变的两端之间选择的点。 确定从线性梯度的一端的点的距离。 距离被量化为与距离成比例的固定值。 评估患者的风险。 根据生理条件分析存储的数据和固定值以表示患者健康。

公开(公告)号：US20090099426A1

公开(公告)日：2009-04-16

申请号：US12249817

申请日：2008-10-10

申请人： Haresh G. Sachanandani ,  Yunlong Zhang

发明人： Haresh G. Sachanandani ,  Yunlong Zhang

IPC分类号： A61B5/02

CPC分类号： A61B5/7275 ,  A61B5/0002 ,  A61B5/02 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/02405 ,  A61B5/02455 ,  A61B5/029 ,  A61B5/0408 ,  A61B5/042 ,  A61B5/0538 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/087 ,  A61B5/1118 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/686 ,  A61B5/7264 ,  A61B5/7282 ,  A61B7/02 ,  A61B7/04 ,  A61N1/3627 ,  A61N1/3704 ,  A61N1/3956 ,  G06F19/00

摘要： This document discusses, among other things, a system comprising a sensor signal processor configured to receive a plurality of electrical sensor signals produced by a plurality of sensors and at least one sensor signal produced by an implantable sensor, a memory that includes information indicating a co-morbidity of a subject, a sensor signal selection circuit that selects a sensor signal to monitor from among the plurality of sensor signals, according to an indicated co-morbidity, a threshold adjustment circuit that adjusts a detection threshold of the selected sensor signal according to the indicated co-morbidity, and a decision circuit that applies the adjusted detection threshold to the selected sensor signal to determine whether an event associated with worsening heart failure (HF) occurred in the subject and outputs an indication of whether the event associated with worsening HF occurred to a user or process.

摘要翻译： 该文件尤其涉及一种包括传感器信号处理器的系统，该传感器信号处理器被配置为接收由多个传感器产生的多个电传感器信号和由可植入传感器产生的至少一个传感器信号，存储器包括指示co 根据所指示的并发症，从所述多个传感器信号中选择要监视的传感器信号的传感器信号选择电路，根据所述传感器信号选择电路调整所选择的传感器信号的检测阈值的阈值调整电路， 指示的并发症，以及决定电路，其将所调整的检测阈值应用于所选择的传感器信号，以确定与受试者中是否发生与恶化的心力衰竭（HF）有关的事件，并且输出与恶化HF相关的事件的指示 发生在用户或进程。

公开(公告)号：US08417325B2

公开(公告)日：2013-04-09

申请号：US12249817

申请日：2008-10-10

申请人： Haresh G. Sachanandani ,  Yunlong Zhang

发明人： Haresh G. Sachanandani ,  Yunlong Zhang

IPC分类号： A61B5/04

CPC分类号： A61B5/7275 ,  A61B5/0002 ,  A61B5/02 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/02405 ,  A61B5/02455 ,  A61B5/029 ,  A61B5/0408 ,  A61B5/042 ,  A61B5/0538 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/087 ,  A61B5/1118 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/686 ,  A61B5/7264 ,  A61B5/7282 ,  A61B7/02 ,  A61B7/04 ,  A61N1/3627 ,  A61N1/3704 ,  A61N1/3956 ,  G06F19/00

摘要： This document discusses, among other things, a system comprising a sensor signal processor configured to receive a plurality of electrical sensor signals produced by a plurality of sensors and at least one sensor signal produced by an implantable sensor, a memory that includes information indicating a co-morbidity of a subject, a sensor signal selection circuit that selects a sensor signal to monitor from among the plurality of sensor signals, according to an indicated co-morbidity, a threshold adjustment circuit that adjusts a detection threshold of the selected sensor signal according to the indicated co-morbidity, and a decision circuit that applies the adjusted detection threshold to the selected sensor signal to determine whether an event associated with worsening heart failure (HF) occurred in the subject and outputs an indication of whether the event associated with worsening HF occurred to a user or process.

公开(公告)号：US20120190992A1

公开(公告)日：2012-07-26

申请号：US13438682

申请日：2012-04-03

申请人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

发明人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

IPC分类号： A61B5/0215 ,  A61B5/042 ,  A61B5/021

CPC分类号： A61B5/0215 ,  A61B5/02007 ,  A61B5/02108 ,  A61B5/08 ,  A61B5/412 ,  A61B5/6846 ,  A61B5/7275

摘要： Systems and methods provide for ambulatorily sensing pulmonary artery pressure from within a patient, and producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure. Power is ambulatorily provided within the patient to facilitate sensing of the pulmonary artery pressure and producing of the pulmonary artery pressure measurement. Acute pulmonary embolism is detected based on a change or rate of change in the pulmonary artery pressure measurement. An alert is preferably generated in response to detecting pulmonary embolism.

摘要翻译： 系统和方法提供了从患者体内动态感测肺动脉压力，并从感测到的肺动脉压力产生肺动脉压力测量。 在患者体内设置动力以便于感测肺动脉压力并产生肺动脉压力测量。 基于肺动脉压力测量的变化或变化率来检测急性肺栓塞。 响应于检测到肺栓塞，优选产生警报。

公开(公告)号：US20090281396A1

公开(公告)日：2009-11-12

申请号：US12414465

申请日：2009-03-30

申请人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

发明人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

IPC分类号： A61B5/0215 ,  A61B5/0205

CPC分类号： A61B5/0215 ,  A61B5/02007 ,  A61B5/02108 ,  A61B5/08 ,  A61B5/412 ,  A61B5/6846 ,  A61B5/7275

摘要： Systems and methods provide for ambulatorily sensing pulmonary artery pressure from within a patient, and producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure. Power is ambulatorily provided within the patient to facilitate sensing of the pulmonary artery pressure and producing of the pulmonary artery pressure measurement. Acute pulmonary embolism is detected based on a change or rate of change in the pulmonary artery pressure measurement. An alert is preferably generated in response to detecting pulmonary embolism.

摘要翻译： 系统和方法提供了从患者体内动态感测肺动脉压力，并从感测到的肺动脉压力产生肺动脉压力测量。 在患者体内设置动力，以便于感测肺动脉压力并产生肺动脉压力测量。 基于肺动脉压力测量的变化或变化率来检测急性肺栓塞。 响应于检测到肺栓塞，优选产生警报。

公开(公告)号：US20090093729A1

公开(公告)日：2009-04-09

申请号：US11866523

申请日：2007-10-03

申请人： Yunlong Zhang ,  Bin Mi ,  Yongxing Zhang

发明人： Yunlong Zhang ,  Bin Mi ,  Yongxing Zhang

IPC分类号： A61B5/0215

CPC分类号： A61B5/02158 ,  A61B5/02007 ,  A61B5/02125 ,  A61B5/0285 ,  A61B5/029 ,  A61B5/1107 ,  A61B5/6876 ,  A61B5/6884 ,  A61B2562/0261 ,  A61B2562/0266

摘要： Embodiments of the invention are related to devices and methods for measuring arterial elasticity and/or blood pressure, amongst other things. In an embodiment, the invention includes an implantable medical device having a sensor element that is configured to engage a vessel of a patient. The sensor element is further configured to generate a signal in response to bending of the sensor element, where bending occurs as a result of changes in the pressure within the vessel. The implantable medical device further includes a controller in signal communication with the sensor element, where the controller is configured to store information regarding the signal generated by the sensor element. Other embodiments are also included herein.

摘要翻译： 本发明的实施例涉及用于测量动脉弹性和/或血压的装置和方法等。 在一个实施例中，本发明包括具有传感器元件的可植入医疗装置，该传感器元件构造成与患者的血管接合。 传感器元件还被配置为响应于传感器元件的弯曲而产生信号，其中由于容器内的压力变化而发生弯曲。 可植入医疗装置还包括与传感器元件信号通信的控制器，其中控制器被配置为存储关于由传感器元件产生的信号的信息。 本文还包括其它实施例。

公开(公告)号：US20090005829A1

公开(公告)日：2009-01-01

申请号：US11769402

申请日：2007-06-27

申请人： Bin Mi ,  Yongxing Zhang ,  Yunlong Zhang ,  James O. Gilkerson

发明人： Bin Mi ,  Yongxing Zhang ,  Yunlong Zhang ,  James O. Gilkerson

IPC分类号： A61N1/365 ,  A61B5/02

CPC分类号： A61N1/056 ,  A61B5/02438 ,  A61B5/02444 ,  A61B5/6846 ,  A61B5/6851 ,  A61N1/36514 ,  A61N1/36578

摘要： Embodiments of the invention are related to implantable devices including movement sensors and related methods for measuring cardiac performance, amongst other things. In an embodiment, the invention includes an implantable electrical stimulation lead. The electrical stimulation lead can include a lead body having a proximal end and a distal end and a sheath defining a central lumen. The lead body can further include an electrical conductor disposed within the central lumen of the sheath. The stimulation lead can further include a stimulation electrode positioned at the distal end of the lead body, the stimulation electrode in electrical communication with the electrical conductor. The electrical stimulation lead can include an flexion sensor coupled to the lead body, the movement sensor configured to generate a signal in response to movement of the lead body. In an embodiment, the invention includes a method of monitoring the condition of a heart failure patient. In an embodiment, the invention includes a method of treating unstable arrhythmia in a patient. Other embodiments are also included herein.

摘要翻译： 本发明的实施例涉及包括运动传感器和用于测量心脏性能的相关方法的可植入装置。 在一个实施例中，本发明包括可植入电刺激引线。 电刺激引线可以包括具有近端和远端的引线主体和限定中心内腔的护套。 引线体还可以包括设置在护套的中心腔内的电导体。 刺激引线还可以包括位于引线体的远端处的刺激电极，该刺激电极与电导体电连通。 电刺激引线可以包括耦合到引线主体的屈曲传感器，所述运动传感器被配置为响应于引线主体的移动而产生信号。 在一个实施例中，本发明包括监测心力衰竭患者状况的方法。 在一个实施方案中，本发明包括治疗患者不稳定性心律失常的方法。 本文还包括其它实施例。