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    System for stimulating autonomic targets from pulmonary artery
    1.
    发明授权
    System for stimulating autonomic targets from pulmonary artery 有权
    从肺动脉刺激自主神经系统

    公开(公告)号：US08527064B2

    公开(公告)日：2013-09-03

    申请号：US12327601

    申请日：2008-12-03

    申请人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

    发明人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0587 ,  A61B5/4035 ,  A61B5/6862 ,  A61B5/6876 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/37288

    摘要： Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.

    摘要翻译： 各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。 神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。 锚结构被配置为长期且牢固地植入神经刺激器，电源和至少一个电极在肺动脉内。 锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。 在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

    SYSTEM FOR STIMULATING AUTONOMIC TARGETS FROM PULMONARY ARTERY
    2.
    发明申请
    SYSTEM FOR STIMULATING AUTONOMIC TARGETS FROM PULMONARY ARTERY 有权
    用于从脉动脉刺激自体目标的系统

    公开(公告)号：US20090228078A1

    公开(公告)日：2009-09-10

    申请号：US12327601

    申请日：2008-12-03

    申请人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

    发明人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0587 ,  A61B5/4035 ,  A61B5/6862 ,  A61B5/6876 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/37288

    摘要： Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.

    摘要翻译： 各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。 神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。 锚结构被配置为长期且牢固地植入神经刺激器，电源和至少一个电极在肺动脉内。 锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。 在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

    CARDIAC OUTPUT ESTIMATION USING PULMONARY ARTERY PRESSURE
    3.
    发明申请
    CARDIAC OUTPUT ESTIMATION USING PULMONARY ARTERY PRESSURE 审中-公开
    使用脉搏压力的心脏输出估计

    公开(公告)号：US20100056931A1

    公开(公告)日：2010-03-04

    申请号：US12543227

    申请日：2009-08-18

    申请人： Leah Soffer ,  Haresh G. Sachanandani ,  Bin Mi ,  Yunlong Zhang

    发明人： Leah Soffer ,  Haresh G. Sachanandani ,  Bin Mi ,  Yunlong Zhang

    IPC分类号： A61B5/0215 ,  A61B5/029

    CPC分类号： A61B5/029 ,  A61B5/0002 ,  A61B5/02028 ,  A61B5/02116 ,  A61B5/0215

    摘要： A system and method sense a pressure signal in a pulmonary artery and compute a stroke volume and cardiac output. A pressure signal is received from an implantable pressure sensor disposed in a pulmonary artery. The pressure signal includes a systolic period and a diastolic period for determining a heart rate (HR) and a heart cycle. An iteratively-updating model can relate pressure signal and HR to a stroke volume (SV) and a cardiac output (CO). The model extracts a mean pulse pressure (MPP) from the PAP signal and receives a patient-specific vascular resistance model parameter and a patient-specific arterial compliance model parameter. CO can be calculated using the HR, the PAP signal, and the model. The vascular resistance model parameter and the arterial compliance model parameter are iteratively updated using the output of the model.

    摘要翻译： 系统和方法检测肺动脉中的压力信号并计算出行程体积和心输出量。 从设置在肺动脉中的可植入压力传感器接收压力信号。 压力信号包括用于确定心率（HR）和心脏周期的收缩期和舒张期。 迭代更新模型可以将压力信号和HR相关联到行程体积（SV）和心输出量（CO）。 该模型从PAP信号中提取平均脉压（MPP），并接收患者特异性血管阻力模型参数和患者特异性动脉顺应性模型参数。 CO可以使用HR，PAP信号和模型来计算。 使用模型的输出迭代地更新血管阻力模型参数和动脉顺应性模型参数。

    IMPLANTABLE VISCOSITY MONITORING DEVICE AND METHOD THEREFOR
    5.
    发明申请
    IMPLANTABLE VISCOSITY MONITORING DEVICE AND METHOD THEREFOR 审中-公开
    可伸缩粘度监测装置及其方法

    公开(公告)号：US20090025459A1

    公开(公告)日：2009-01-29

    申请号：US11781769

    申请日：2007-07-23

    申请人： Yunlong Zhang ,  Bin Mi

    发明人： Yunlong Zhang ,  Bin Mi

    IPC分类号： G01N11/10

    CPC分类号： A61B5/0031 ,  A61B5/6882

    摘要： An apparatus includes an implantable acoustic viscosity sensor configured to acoustically obtain a viscosity signal indicative of a viscosity of a fluid in contact with the viscosity sensor. A viscosity measurement circuit produces a viscosity measurement from the viscosity signal.

    摘要翻译： 一种装置包括可植入声学粘度传感器，其构造成声学地获得指示与粘度传感器接触的流体的粘度的粘度信号。 粘度测量电路根据粘度信号产生粘度测量。

    System and method for detection of pulmonary embolism
    7.
    发明授权
    System and method for detection of pulmonary embolism 有权
    用于肺栓塞检测的系统和方法

    公开(公告)号：US08147415B2

    公开(公告)日：2012-04-03

    申请号：US12414465

    申请日：2009-03-30

    申请人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

    发明人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

    IPC分类号： A61B5/02

    CPC分类号： A61B5/0215 ,  A61B5/02007 ,  A61B5/02108 ,  A61B5/08 ,  A61B5/412 ,  A61B5/6846 ,  A61B5/7275

    摘要： Systems and methods provide for ambulatorily sensing pulmonary artery pressure from within a patient, and producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure. Power is ambulatorily provided within the patient to facilitate sensing of the pulmonary artery pressure and producing of the pulmonary artery pressure measurement. Acute pulmonary embolism is detected based on a change or rate of change in the pulmonary artery pressure measurement. An alert is preferably generated in response to detecting pulmonary embolism.

    摘要翻译： 系统和方法提供了从患者体内动态感测肺动脉压力，并从感测到的肺动脉压力产生肺动脉压力测量。 在患者体内设置动力以便于感测肺动脉压力并产生肺动脉压力测量。 基于肺动脉压力测量的变化或变化率来检测急性肺栓塞。 响应于检测到肺栓塞，优选产生警报。

    SYSTEM AND METHODS FOR PULMONARY EDEMA DETECTION WITH IMPLANTABLE ACOUSTIC DEVICES
    8.
    发明申请
    SYSTEM AND METHODS FOR PULMONARY EDEMA DETECTION WITH IMPLANTABLE ACOUSTIC DEVICES 审中-公开
    用于具有可植入声学设备的脉冲EDEMA检测的系统和方法

    公开(公告)号：US20110009746A1

    公开(公告)日：2011-01-13

    申请号：US12832554

    申请日：2010-07-08

    申请人： Binh C. Tran ,  Bin Mi ,  Yunlong Zhang

    发明人： Binh C. Tran ,  Bin Mi ,  Yunlong Zhang

    IPC分类号： A61B8/00

    CPC分类号： A61B8/08 ,  A61B5/4878 ,  A61B8/12

    摘要： A system includes a first implantable acoustic transducer, a second implantable transducer a memory circuit, and a processor. The first implantable acoustic transducer is configured to receive transmitted acoustic energy from a thorax region of a subject and the second implantable acoustic transducer is configured to transmit the acoustic energy to the thorax region. The processor is communicatively coupled to the first acoustic transducer, the second acoustic transducer, and the memory circuit. The processor includes a parameter module configured to measure a parameter of the received acoustic energy, and a trending module configured to trend the measured parameter and to provide an indication of pulmonary edema status of the subject using the parameter trend.

    摘要翻译： 系统包括第一可植入声学换能器，第二可植入换能器，存储器电路和处理器。 第一可植入声学换能器被配置为从受试者的胸部区域接收传输的声能，并且第二可植入声学换能器被配置为将声能传递到胸部区域。 处理器通信地耦合到第一声换能器，第二声换能器和存储器电路。 所述处理器包括被配置为测量所接收的声能的参数的参数模块，以及配置成趋向所述测量参数并使用所述参数趋势提供所述对象的肺水肿状态的指示的趋势模块。

    SYSTEM AND METHOD FOR DETECTION OF PULMONARY EMBOLISM
    10.
    发明申请
    SYSTEM AND METHOD FOR DETECTION OF PULMONARY EMBOLISM 有权
    用于检测肺动脉栓塞的系统和方法

    公开(公告)号：US20120190992A1

    公开(公告)日：2012-07-26

    申请号：US13438682

    申请日：2012-04-03

    申请人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

    发明人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

    IPC分类号： A61B5/0215 ,  A61B5/042 ,  A61B5/021

    CPC分类号： A61B5/0215 ,  A61B5/02007 ,  A61B5/02108 ,  A61B5/08 ,  A61B5/412 ,  A61B5/6846 ,  A61B5/7275

    摘要： Systems and methods provide for ambulatorily sensing pulmonary artery pressure from within a patient, and producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure. Power is ambulatorily provided within the patient to facilitate sensing of the pulmonary artery pressure and producing of the pulmonary artery pressure measurement. Acute pulmonary embolism is detected based on a change or rate of change in the pulmonary artery pressure measurement. An alert is preferably generated in response to detecting pulmonary embolism.

    摘要翻译： 系统和方法提供了从患者体内动态感测肺动脉压力，并从感测到的肺动脉压力产生肺动脉压力测量。 在患者体内设置动力以便于感测肺动脉压力并产生肺动脉压力测量。 基于肺动脉压力测量的变化或变化率来检测急性肺栓塞。 响应于检测到肺栓塞，优选产生警报。