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公开(公告)号：US20140350680A1
公开(公告)日：2014-11-27
申请号：US14367870
申请日：2012-12-22
申请人： Dang Quang Svend Le , Muwan Chen , Menglin Chen , Anette Overgaard Baatrup , Cody Eric Bünger , Helle Lysdahl , Jørgen Kjems , Morten Østergaard Andersen , Flemming Besenbacher
发明人： Dang Quang Svend Le , Muwan Chen , Menglin Chen , Anette Overgaard Baatrup , Cody Eric Bünger , Helle Lysdahl , Jørgen Kjems , Morten Østergaard Andersen , Flemming Besenbacher
CPC分类号： A61L27/14 , A61F2/105 , A61F2/28 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , A61L2400/18
摘要： The present invention relates to a process for modifying the surface morphology of a medical device. The modified surface has, among other advantageous properties, an improved capacity for sorption or conjugation of a variety of bioactive agents, the addition of which will turn the medical device into a localized drug delivery system.
摘要翻译： 本发明涉及用于改变医疗装置的表面形态的方法。 改进的表面除了其它有利的性质之外还具有改进的各种生物活性剂的吸附或缀合的能力，其添加将将医疗装置转变成局部药物递送系统。
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公开(公告)号：US20110033547A1
公开(公告)日：2011-02-10
申请号：US12667204
申请日：2008-07-04
IPC分类号： A61K9/14 , A61K31/713 , A61K39/395 , A61K38/40 , B82Y5/00 , B82Y40/00
CPC分类号： A61K48/0041 , A61K9/5161 , C12N15/111 , C12N2310/14 , C12N2320/51
摘要： The present invention relates to dehydrated nanoparticles comprising chitosan and a nucleic acid. Preferably, the nucleic acid is a siRNA. Dehydrated nanoparticles of the invention have improved storage characteristics. The particles may be used in screening methods, e.g. where they have been dried onto a solid support, such as the surface of a culture well. The nanoparticles may also be dried onto implants for tissue engineering scaffolds, where they enable transfection of cells growing on the scaffold. Moreover, the particles have therapeutic relevance.
摘要翻译： 本发明涉及包含壳聚糖和核酸的脱水纳米粒子。 优选地，核酸是siRNA。 本发明的脱水纳米颗粒具有改善的储存特性。 颗粒可用于筛选方法，例如， 它们已经被干燥到固体支持物上，例如培养物的表面。 纳米颗粒也可以干燥到用于组织工程支架的植入物上，其中它们能够转染在支架上生长的细胞。 此外，颗粒具有治疗相关性。
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