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    ADAMTS13 genes and proteins and variants, and therapeutic compositions and methods of utilizing the same
    2.
    发明授权
    ADAMTS13 genes and proteins and variants, and therapeutic compositions and methods of utilizing the same 有权
    ADAMTS13基因和蛋白质和变体，以及利用其的治疗组合物和方法

    公开(公告)号：US08273714B2

    公开(公告)日：2012-09-25

    申请号：US12422809

    申请日：2009-04-13

    申请人： David Ginsburg ,  Gallia Levy ,  Han-Mou Tsai

    发明人： David Ginsburg ,  Gallia Levy ,  Han-Mou Tsai

    IPC分类号： A61K38/36 ,  A61K38/48 ,  C12N15/57 ,  C12N15/79 ,  C12N15/85

    CPC分类号： C12N9/6489 ,  C12Q1/6883 ,  C12Q2600/156

    摘要： The present invention relates to a disintegrin and metalloproteinase containing thrombospondin 1-like domains (ADAMTS) and in particular to a novel ADAMTS13 protease and to nucleic acids encoding ADAMTS13 proteases. The present invention encompasses both native and recombinant wild-type forms of ADAMTS13, as well as mutant and variant forms including fragments, some of which posses altered characteristics relative to the wild-type ADAMTS13. The present invention also relates to methods of using ADAMTS13, including for treatment of TTP. The present invention also relates to methods for screening for the presence of TTP. The present invention further relates to methods for developing anticoagulant drugs based upon ADAMTS13.

    摘要翻译： 本发明涉及含有血小板反应素1-样结构域（ADAMTS）的解联蛋白和金属蛋白酶，特别涉及新的ADAMTS13蛋白酶和编码ADAMTS13蛋白酶的核酸。 本发明包括天然和重组野生型ADAMTS13，以及包括片段的突变体和变体形式，其中一些相对于野生型ADAMTS13具有改变的特征。 本发明还涉及使用ADAMTS13的方法，包括用于治疗TTP。 本发明还涉及筛选TTP的存在的方法。 本发明还涉及基于ADAMTS13开发抗凝药物的方法。

    DNA encoding Von Willebrand Factor (VWF) and methods and cells for producing VFW, and VFW produced by the DNA, methods and cells
    3.
    发明授权
    DNA encoding Von Willebrand Factor (VWF) and methods and cells for producing VFW, and VFW produced by the DNA, methods and cells 失效
    编码Von Willebrand因子（VWF）的DNA和用于产生VWF的方法和细胞，以及由DNA，方法和细胞产生的VWF

    公开(公告)号：US08597910B1

    公开(公告)日：2013-12-03

    申请号：US07559509

    申请日：1990-07-23

    申请人： David Ginsburg ,  Stuart H. Orkin ,  Randal J. Kaufman

    发明人： David Ginsburg ,  Stuart H. Orkin ,  Randal J. Kaufman

    IPC分类号： C12P21/04 ,  C12N15/00 ,  C12N5/07 ,  A61K35/14 ,  C07H21/04

    CPC分类号： C07K14/755 ,  A61K38/37

    摘要： Von Willebrand's Factor (VWF) is produced using an expression vector that includes: 1) a DNA sequence encoding a functional VWF protein; and 2) regulatory DNA capable of effecting expression of that DNA sequence in a host cell transformed with the vector. Restriction fragment length polymorphisms (RFLP's) associated with the VWF gene are identified and used in a probe for determining the source of a VWF gene in a DNA sample. The gene for VWF is localized to the short arm of human chromosome 12 (12p).

    摘要翻译： 冯维勒布兰氏因子（VWF）使用表达载体产生，所述表达载体包括：1）编码功能性VWF蛋白的DNA序列; 和2）能够在用载体转化的宿主细胞中实现该DNA序列的表达的调节DNA。 鉴定与VWF基因相关的限制性片段长度多态性（RFLP），并用于确定DNA样品中VWF基因来源的探针中。 VWF的基因定位于人染色体12（12p）的短臂。

    ADAMTS13 genes and proteins and variants, and uses thereof
    6.
    发明申请
    ADAMTS13 genes and proteins and variants, and uses thereof 有权

    公开(公告)号：US20060246589A1

    公开(公告)日：2006-11-02

    申请号：US11378752

    申请日：2006-03-17

    申请人： David Ginsburg ,  Gallia Levy ,  Han-Mou Tsai

    发明人： David Ginsburg ,  Gallia Levy ,  Han-Mou Tsai

    IPC分类号： C12N15/74

    CPC分类号： C12N9/6489 ,  C12Q1/6883 ,  C12Q2600/156

    摘要： The present invention relates to a disintegrin and metalloproteinase containing thrombospondin 1-like domains (ADAMTS) and in particular to a novel ADAMTS13 protease and to nucleic acids encoding ADAMTS13 proteases. The present invention encompasses both native and recombinant wild-type forms of ADAMTS13, as well as mutant and variant forms including fragments, some of which posses altered characteristics relative to the wild-type ADAMTS13. The present invention also relates to methods of using ADAMTS13, including for treatment of TTP. The present invention also relates to methods for screening for the presence of TTP. The present invention further relates to methods for developing anticoagulant drugs based upon ADAMTS13.

    ADAMTS13 genes and proteins and variants, and therapeutic compositions and methods of utilizing the same
    7.
    发明授权
    ADAMTS13 genes and proteins and variants, and therapeutic compositions and methods of utilizing the same 有权
    ADAMTS13基因和蛋白质和变体，以及利用其的治疗组合物和方法

    公开(公告)号：US08394373B2

    公开(公告)日：2013-03-12

    申请号：US12422803

    申请日：2009-04-13

    申请人： David Ginsburg ,  Gallia Levy ,  Han-Mou Tsai

    发明人： David Ginsburg ,  Gallia Levy ,  Han-Mou Tsai

    IPC分类号： A61K38/48 ,  C12N9/48

    CPC分类号： C12N9/6489 ,  C12Q1/6883 ,  C12Q2600/156

    摘要： The present invention relates to a disintegrin and metalloproteinase containing thrombospondin 1-like domains (ADAMTS) and in particular to a novel ADAMTS13 protease and to nucleic acids encoding ADAMTS13 proteases. The present invention encompasses both native and recombinant wild-type forms of ADAMTS13, as well as mutant and variant forms including fragments, some of which posses altered characteristics relative to the wild-type ADAMTS13. The present invention also relates to methods of using ADAMTS13, including for treatment of TTP. The present invention also relates to methods for screening for the presence of TTP. The present invention further relates to methods for developing anticoagulant drugs based upon ADAMTS13.

    摘要翻译： 本发明涉及含有血小板反应素1-样结构域（ADAMTS）的解联蛋白和金属蛋白酶，特别涉及新的ADAMTS13蛋白酶和编码ADAMTS13蛋白酶的核酸。 本发明包括天然和重组野生型ADAMTS13，以及包括片段的突变体和变体形式，其中一些相对于野生型ADAMTS13具有改变的特征。 本发明还涉及使用ADAMTS13的方法，包括用于治疗TTP。 本发明还涉及筛选TTP的存在的方法。 本发明还涉及基于ADAMTS13开发抗凝药物的方法。

    ADAMTS13 genes and proteins and variants and therapeutic compositions and methods utilizing the same
    9.
    发明授权
    ADAMTS13 genes and proteins and variants and therapeutic compositions and methods utilizing the same 有权
    ADAMTS13基因和蛋白质和变体以及使用其的治疗组合物和方法

    公开(公告)号：US07517522B2

    公开(公告)日：2009-04-14

    申请号：US11342461

    申请日：2006-01-30

    申请人： David Ginsburg ,  Gallia Levy ,  Han-Mou Tsai

    发明人： David Ginsburg ,  Gallia Levy ,  Han-Mou Tsai

    IPC分类号： A61K38/48 ,  C12N9/48

    CPC分类号： C12N9/6489 ,  C12Q1/6883 ,  C12Q2600/156

    摘要： The present invention relates to a disintegrin and metalloproteinase containing thrombospondin 1-like domains (ADAMTS) and in particular to a novel ADAMTS13 protease and to nucleic acids encoding ADAMTS13 proteases. The present invention encompasses both native and recombinant wild-type forms of ADAMTS13, as well as mutant and variant forms including fragments, some of which posses altered characteristics relative to the wild-type ADAMTS13. The present invention also relates to methods of using ADAMTS13, including for treatment of TTP. The present invention also relates to methods for screening for the presence of TTP. The present invention further relates to methods for developing anticoagulant drugs based upon ADAMTS13.

    摘要翻译： 本发明涉及含有血小板反应素1-样结构域（ADAMTS）的解联蛋白和金属蛋白酶，特别涉及新的ADAMTS13蛋白酶和编码ADAMTS13蛋白酶的核酸。 本发明包括天然和重组野生型ADAMTS13，以及包括片段的突变体和变体形式，其中一些相对于野生型ADAMTS13具有改变的特征。 本发明还涉及使用ADAMTS13的方法，包括用于治疗TTP。 本发明还涉及筛选TTP的存在的方法。 本发明还涉及基于ADAMTS13开发抗凝药物的方法。

    ADAMTS13 genes and proteins and variants, and uses thereof
    10.
    发明申请
    ADAMTS13 genes and proteins and variants, and uses thereof 有权

    公开(公告)号：US20060233784A1

    公开(公告)日：2006-10-19

    申请号：US11342461

    申请日：2006-01-30

    申请人： David Ginsburg ,  Gallia Levy ,  Han-Mou Tsai

    发明人： David Ginsburg ,  Gallia Levy ,  Han-Mou Tsai

    IPC分类号： A61K38/46

    CPC分类号： C12N9/6489 ,  C12Q1/6883 ,  C12Q2600/156

    摘要： The present invention relates to a disintegrin and metalloproteinase containing thrombospondin 1-like domains (ADAMTS) and in particular to a novel ADAMTS13 protease and to nucleic acids encoding ADAMTS13 proteases. The present invention encompasses both native and recombinant wild-type forms of ADAMTS13, as well as mutant and variant forms including fragments, some of which posses altered characteristics relative to the wild-type ADAMTS13. The present invention also relates to methods of using ADAMTS13, including for treatment of TTP. The present invention also relates to methods for screening for the presence of TTP. The present invention further relates to methods for developing anticoagulant drugs based upon ADAMTS13.