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1.发明申请Method and array for determining the focal position during imaging of a sample 有权用于在样品成像期间确定焦点位置的方法和阵列公开(公告)号：US20070102620A1
公开(公告)日：2007-05-10
申请号：US10554899
申请日：2004-04-27
申请人： Daniel Bublitz , Dieter Graefe , Peter Westphal
发明人： Daniel Bublitz , Dieter Graefe , Peter Westphal
CPC分类号： G02B21/244 , G02B7/32 , G02B21/245
摘要： The invention refers to a process for determining the focus position when imaging a specimen (4) with a field stop imaged onto the specimen detecting this image using a position-sensitive receiving-device inclined relative to the field stop defining the focus position by means of intensity distribution in the receiving device. The invention also refers to set-ups as regards implementation of the process according to the invention. According to the invention, in a process of the above-mentioned type, imaging of the field stop onto the specimen (4) is at least partially superposed by an optical lattice; the position-sensitive receiving device is used to determine intensity values for the light reflected by the specimen; these intensity values are assigned to positions in the receiving device; position-related contrast values are determined from the position-related intensity values; the position of the contrast focus in the receiving device as equivalent of the current focus position is determined using these contrast values.
摘要翻译： 一种用于通过利用接收装置中的强度分布相对于通过强度分布定义聚焦位置的场停止而倾斜的位置敏感的接收装置对具有使用场停止成像的样本成像到检测该图像的样本上的确定焦点位置的处理。 本发明还包括用于实施根据本发明的方法的装置。 根据本发明，在上述类型的过程中，场停止物到样本上的成像至少部分地被光栅重叠; 位置敏感接收装置用于确定由样本反射的光的强度值; 这些强度值被分配给接收装置中的位置; 与位置相关的强度值确定位置相关的对比度值; 使用这些对比度值确定接收装置中的对比度聚焦的位置等同于当前焦点位置。
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2.发明授权公开(公告)号：US07488924B2
公开(公告)日：2009-02-10
申请号：US10554899
申请日：2004-04-27
申请人： Daniel Bublitz , Dieter Graefe , Peter Westphal
发明人： Daniel Bublitz , Dieter Graefe , Peter Westphal
CPC分类号： G02B21/244 , G02B7/32 , G02B21/245
摘要： The invention refers to a process for determining the focus position when imaging a specimen (4) with a field stop imaged onto the specimen detecting this image using a position-sensitive receiving-device inclined relative to the field stop defining the focus position by means of intensity distribution in the receiving device. The invention also refers to set-ups as regards implementation of the process according to the invention.According to the invention, in a process of the above-mentioned type, imaging of the field stop onto the specimen (4) is at least partially superposed by an optical lattice; the position-sensitive receiving device is used to determine intensity values for the light reflected by the specimen; these intensity values are assigned to positions in the receiving device; position-related contrast values are determined from the position-related intensity values; the position of the contrast focus in the receiving device as equivalent of the current focus position is determined using these contrast values.
摘要翻译： 一种用于通过利用接收装置中的强度分布相对于通过强度分布定义聚焦位置的场停止而倾斜的位置敏感的接收装置对具有使用场停止成像的样本成像到检测该图像的样本上的确定焦点位置的处理。 本发明还包括用于实施根据本发明的方法的装置。 根据本发明，在上述类型的过程中，场停止物到样本上的成像至少部分地被光栅重叠; 位置敏感接收装置用于确定由样本反射的光的强度值; 这些强度值被分配给接收装置中的位置; 与位置相关的强度值确定位置相关的对比度值; 使用这些对比度值确定接收装置中的对比度聚焦的位置等同于当前焦点位置。
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3.发明授权公开(公告)号：US07926945B2
公开(公告)日：2011-04-19
申请号：US11988965
申请日：2006-07-19
申请人： Manfred Dick , Thomas Mohr , Daniel Bublitz , Peter Westphal
发明人： Manfred Dick , Thomas Mohr , Daniel Bublitz , Peter Westphal
CPC分类号： A61B3/14 , A61B5/0261 , A61B5/0285 , A61B5/14555 , A61B5/7257
摘要： The present invention is directed to a device and a method for the observation, documentation and/or diagnosis of the fundus in which the diagnosis is carried out by evaluating the documented images of the fundus. The device according to the invention comprises an ophthalmological examination device, a multi-spectral sequential illumination module, an image recording module, a control and safety module, and an evaluating unit. The illumination module which is connected to the ophthalmologic examination device has at least two individual light sources and which can be regulated individually with respect to intensity and duration and which emit monochromatic light of different wavelengths. The light coming from the illumination module is imaged on the image recording module from the ophthalmologic examination device by the eye being examined. The control and safety module controls the chronological sequence, duration and intensity of the individual light sources and monitors the light stress. An evaluating unit evaluates the recordings of the fundus transmitted by the image recording module. The inventive solution serves to record monochromatic images of the retina, for example, red, green, blue, or also infrared, and to record fluorescence images.
摘要翻译： 本发明涉及一种用于观察，记录和/或诊断眼底的装置和方法，其中通过评估眼底记录的图像进行诊断。 根据本发明的装置包括眼科检查装置，多光谱顺序照明模块，图像记录模块，控制和安全模块以及评估单元。 连接到眼科检查装置的照明模块具有至少两个单独的光源，并且可以相对于强度和持续时间单独地调节并且发射不同波长的单色光。 来自照明模块的光被眼睛检查从眼科检查装置成像在图像记录模块上。 控制和安全模块控制各个光源的时间顺序，持续时间和强度，并监控光应力。 评估单元评估由图像记录模块发送的眼底的记录。 本发明的解决方案用于记录视网膜的单色图像，例如红色，绿色，蓝色或红外，并记录荧光图像。
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公开(公告)号：US08643946B2
公开(公告)日：2014-02-04
申请号：US12305183
申请日：2007-06-15
申请人： Peter Westphal , Daniel Bublitz , Reiner Mitzkus
发明人： Peter Westphal , Daniel Bublitz , Reiner Mitzkus
IPC分类号： G02B21/00
CPC分类号： G02B7/36 , G02B21/244
摘要： A microscope including an objective, which images a sample along a microscope beam path, and an autofocus device, which is coupled into the microscope beam path via a beam splitter at a location behind the objective. A light modulator for generating a two-dimensional, intensity-modulated modulation object, is located in the autofocus beam path in a plane conjugated to the focal plane of the objective or intersects the latter and is imaged into the focal plane of the objective. A camera records a two-dimensional image onto which the modulation object's image is imaged. The image plane of the camera intersects a plane that is conjugated to the modulation object or is located in the plane and the camera detecting the contrast of the modulation object's image located in the sample.
摘要翻译： 显微镜，其包括沿着显微镜光束路径对样品进行成像的物镜和自动聚焦装置，该自动对焦装置经由目标背后的位置处的分束器耦合到显微镜光束路径中。 用于产生二维强度调制调制对象的光调制器位于与物镜的焦平面共轭的平面中的自动聚焦光束路径中，或者与物镜的焦平面相交，并被成像到物镜的焦平面。 照相机记录调制对象的图像成像到的二维图像。 相机的图像平面与共轭于调制对象的平面相交，或位于平面中，相机检测位于样本中的调制对象的图像的对比度。
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公开(公告)号：US08097865B2
公开(公告)日：2012-01-17
申请号：US12083980
申请日：2006-11-09
申请人： Peter Westphal , Daniel Bublitz
发明人： Peter Westphal , Daniel Bublitz
IPC分类号： G01N33/48
CPC分类号： G01N21/64 , F21V9/08 , G01N21/6458 , G02B19/0028 , G02B19/0066 , G02B19/0095 , G02B21/06 , G02B21/16 , G02B27/1006 , G02B27/141 , G02B27/145
摘要： An illumination device includes at least four semiconductor radiation sources (18) for emitting optical radiation in respectively different emission wavelength ranges. At least one color splitter (22.1, 22.2, 22.3), which is reflective for optical radiation of the respective semiconductor radiation source (18), is assigned to each of at least three of the semiconductor radiation sources (18). The semiconductor radiation sources (18) and the color splitters (22.1, 22.2, 22.3) are arranged such that the optical radiation, which is emitted in each case from each of the semiconductor radiation sources (18), is coupled into a common illumination beam path section (24). In each case, one collimating unit (20.1, 20.2, 20.3, 20.4), which collimates the optical radiation emitted by the respective semiconductor radiation source (18), is arranged in the beam path sections from the semiconductor radiation sources (18) to the color splitters (22.1, 22.2, 22.3).
摘要翻译： 照明装置包括用于分别发射不同发射波长范围内的光辐射的至少四个半导体辐射源（18）。 对于半导体辐射源（18）中的至少三个中的每一个分配至少一个用于相应半导体辐射源（18）的光学辐射的颜色分离器（22.1,22.2,22.3）。 半导体辐射源（18）和分色器（22.1,22.2,22.3）被布置成使得从每个半导体辐射源（18）在每种情况下发射的光辐射被耦合到公共照明光束 路径部分（24）。 在每种情况下，将从半导体辐射源（18）发射的光辐射准直的一个准直单元（20.1,20.2,20.3,20.4）设置在从半导体辐射源（18）到 分色机（22.1,22.2,22.3）。
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6.发明申请公开(公告)号：US20090153798A1
公开(公告)日：2009-06-18
申请号：US11988965
申请日：2006-07-19
申请人： Manfred Dick , Thomas Mohr , Daniel Bublitz , Peter Westphal
发明人： Manfred Dick , Thomas Mohr , Daniel Bublitz , Peter Westphal
CPC分类号： A61B3/14 , A61B5/0261 , A61B5/0285 , A61B5/14555 , A61B5/7257
摘要： The present invention is directed to a device and a method for the observation, documentation and/or diagnosis of the fundus in which the diagnosis is carried out by evaluating the documented images of the fundus. The device according to the invention comprises an ophthalmological examination device, a multi-spectral sequential illumination module, an image recording module, a control and safety module, and an evaluating unit. The illumination module which is connected to the ophthalmologic examination device has at least two individual light sources and which can be regulated individually with respect to intensity and duration and which emit monochromatic light of different wavelengths. The light coming from the illumination module is imaged on the image recording module from the ophthalmologic examination device by the eye being examined. The control and safety module controls the chronological sequence, duration and intensity of the individual light sources and monitors the light stress. An evaluating unit evaluates the recordings of the fundus transmitted by the image recording module. The inventive solution serves to record monochromatic images of the retina, for example, red, green, blue, or also infrared, and to record fluorescence images.
摘要翻译： 本发明涉及一种用于观察，记录和/或诊断眼底的装置和方法，其中通过评估眼底记录的图像进行诊断。 根据本发明的装置包括眼科检查装置，多光谱顺序照明模块，图像记录模块，控制和安全模块以及评估单元。 连接到眼科检查装置的照明模块具有至少两个单独的光源，并且可以相对于强度和持续时间单独地调节并且发射不同波长的单色光。 来自照明模块的光被眼睛检查从眼科检查装置成像在图像记录模块上。 控制和安全模块控制各个光源的时间顺序，持续时间和强度，并监控光应力。 评估单元评估由图像记录模块发送的眼底的记录。 本发明的解决方案用于记录视网膜的单色图像，例如红色，绿色，蓝色或红外，并记录荧光图像。
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公开(公告)号：US20090121154A1
公开(公告)日：2009-05-14
申请号：US12083980
申请日：2006-11-09
申请人： Peter Westphal , Daniel Bublitz
发明人： Peter Westphal , Daniel Bublitz
CPC分类号： G01N21/64 , F21V9/08 , G01N21/6458 , G02B19/0028 , G02B19/0066 , G02B19/0095 , G02B21/06 , G02B21/16 , G02B27/1006 , G02B27/141 , G02B27/145
摘要： An illumination device includes at least four semiconductor radiation sources (18) for emitting optical radiation in respectively different emission wavelength ranges. At least one color splitter (22.1, 22.2, 22.3), which is reflective for optical radiation of the respective semiconductor radiation source (18), is assigned to each of at least three of the semiconductor radiation sources (18). The semiconductor radiation sources (18) and the color splitters (22.1, 22.2, 22.3) are arranged such that the optical radiation, which is emitted in each case from each of the semiconductor radiation sources (18), is coupled into a common illumination beam path section (24). In each case, one collimating unit (20.1, 20.2, 20.3, 20.4), which collimates the optical radiation emitted by the respective semiconductor radiation source (18), is arranged in the beam path sections from the semiconductor radiation sources (18) to the color splitters (22.1, 22.2, 22.3).
摘要翻译： 照明装置包括用于分别发射不同发射波长范围内的光辐射的至少四个半导体辐射源（18）。 对于半导体辐射源（18）中的至少三个中的每一个分配至少一个用于相应半导体辐射源（18）的光学辐射的颜色分离器（22.1,22.2,22.3）。 半导体辐射源（18）和分色器（22.1,22.2,22.3）被布置成使得从每个半导体辐射源（18）在每种情况下发射的光辐射被耦合到公共照明光束 路径部分（24）。 在每种情况下，将从半导体辐射源（18）发射的光辐射准直的一个准直单元（20.1,20.2,20.3,20.4）设置在从半导体辐射源（18）到 分色机（22.1,22.2,22.3）。
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公开(公告)号：US20100066823A1
公开(公告)日：2010-03-18
申请号：US12307718
申请日：2007-06-27
申请人： Peter Westphal , Daniel Bublitz
发明人： Peter Westphal , Daniel Bublitz
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/06 , G02B21/16
摘要： A method for producing an image of a layer of an object by a wide field optical element on a resolving detector. The object is illuminated in a focused manner on at least one object plane having at least two binary illuminating patterns. The corresponding images are detected. Light and/or the dark areas of the illuminating patterns completely cover the object when the illuminating pattern is superimposed. A layer image determined from the detected images, includes a partial segment that respectively reproduces a partial area of the object that is arranged inside the light area of one of the used illuminating patterns. Edges are arranged at a distance from the edges of the light area about at least one predefined minimum distance.
摘要翻译： 一种用于通过分辨率检测器上的宽场光学元件产生物体层的图像的方法。 物体以聚焦方式照射在具有至少两个二进制照明图案的至少一个物体平面上。 检测相应的图像。 当照明图案叠加时，照明图案的光和/或暗区完全覆盖物体。 从检测到的图像确定的层图像包括分别再现布置在所使用的照明图案之一的光区域内的对象的部分区域的部分片段。 边缘布置在与光区域的边缘相距一定距离上约至少一个预定的最小距离。
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公开(公告)号：US07416313B2
公开(公告)日：2008-08-26
申请号：US10551265
申请日：2004-03-09
申请人： Peter Westphal , Daniel Bublitz
发明人： Peter Westphal , Daniel Bublitz
IPC分类号： F21V21/14
CPC分类号： G02B21/06 , G02B21/16 , G02B21/28 , Y10S362/80
摘要： The invention relates to an assembly for illuminating objects with light of different wavelengths in microscopes, automatic microscopes and devices for fluorescent microscopy applications. Said assembly comprises LED light sources for illuminating the objects, which are positioned in the illumination beam path of the microscope or device. A receiving element (6; 13) that can be rotated about a rotational axis (5) is provided with respective fixing elements (7) for at least one LED (3; 3.1). The receiving device (6; 13) is situated in a housing (1) that can be placed on or positioned in the device housing (18). A drive unit (9) for the defined adjustment of the receiving device (6; 13) is provided in such a way that the LED (3; 3.1) can be positioned in front of a light emission opening of the housing (1) with the respective focal point wavelength that is required for measuring and/or observation purposes.
摘要翻译： 本发明涉及一种用于在显微镜中用不同波长的光照射物体的组件，用于荧光显微镜应用的自动显微镜和装置。 所述组件包括用于照亮位于显微镜或装置的照明光束路径中的物体的LED光源。 可以围绕旋转轴线（5）旋转的接收元件（6; 13）设置有用于至少一个LED（3; 3.1）的相应的固定元件（7）。 接收装置（6; 13）位于可以放置在装置壳体（18）中或定位在装置壳体（18）中的壳体（1）中。 提供用于接收装置（6; 13）的限定调整的驱动单元（9），使得LED（3; 3.1）可以被定位在壳体（1）的发光开口的前面， 测量和/或观察目的所需的各个焦点波长。
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公开(公告)号：US20060187542A1
公开(公告)日：2006-08-24
申请号：US10551265
申请日：2004-03-09
申请人： Peter Westphal , Daniel Bublitz
发明人： Peter Westphal , Daniel Bublitz
CPC分类号： G02B21/06 , G02B21/16 , G02B21/28 , Y10S362/80
摘要： The invention relates to an assembly for illuminating objects with light of different wavelengths in microscopes, automatic microscopes and devices for fluorescent microscopy applications. Said assembly comprises LED light sources for illuminating the objects, which are positioned in the illumination beam path of the microscope or device. A receiving element (6; 13) that can be rotated about a rotational axis (5) is provided with respective fixing elements (7) for at least one LED (3; 3.1). The receiving device (6; 13) is situated in a housing (1) that can be placed on or positioned in the device housing (18). A drive unit (9) for the defined adjustment of the receiving device (6; 13) is provided in such a way that the LED (3; 3.1) can be positioned in front of a light emission opening of the housing (1) with the respective focal point wavelength that is required for measuring and/or observation purposes.
摘要翻译： 本发明涉及一种用于在显微镜中用不同波长的光照射物体的组件，用于荧光显微镜应用的自动显微镜和装置。 所述组件包括用于照亮位于显微镜或装置的照明光束路径中的物体的LED光源。 可以围绕旋转轴线（5）旋转的接收元件（6; 13）设置有用于至少一个LED（3; 3.1）的相应的固定元件（7）。 接收装置（6; 13）位于可以放置在装置壳体（18）中或定位在装置壳体（18）中的壳体（1）中。 提供用于接收装置（6; 13）的限定调整的驱动单元（9），使得LED（3; 3.1）可以被定位在壳体（1）的发光开口的前面， 测量和/或观察目的所需的各个焦点波长。
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